COX
Cyclooxygenase
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).
COX Isoform Specific Products
All Product Categories
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COX Related Products (1322)
Related Products (1322)
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Antibodies (6)
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COX Isoform Comparison
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Thiazolinobutazone
0 ImagesCat. No.: HY-B0230ACAS No.: 54749-86-9Synonyms: LAS 11871Thiazolinobutazone is a COX inhibitor. Thiazolinobutazone has less toxic than Phenylbutazone (HY-B0230). Thiazolinobutazone can be used in the study of immunological diseases.
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Hirsutanonol
0 ImagesCat. No.: HY-N4044CAS No.: 41137-86-4Synonyms: (5S)-HirsutanonolHirsutanonol ((5S)-Hirsutanonol) is a diarylheptanoid that can be isolated from the bark of Alnus hirsute var. sibirica. Hirsutanonol inhibits cyclooxygenase-2 (COX-2) expression. Hirsutanonol has anti-filarial with an IC50 value of 44.11 μg/mL for microfilariae.
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Rofecoxib-d5
0 ImagesCat. No.: HY-17372SCAS No.: 544684-93-7Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
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β-Selinene
0 ImagesCat. No.: HY-W747297CAS No.: 17066-67-0β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus (Callicarpa macrophylla). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals (DPPH, NO, •OH) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase (COX) activity, reduce prostaglandin (such as PGE₂) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects.
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COX-2/5-LOX-IN-6
0 ImagesCat. No.: HY-181044COX-2/5-LOX-IN-6 (Compound 4c) is a potent and selective 5-LOX (IC50 = 0.10 μM) and COX-2 (IC50: 2.88 μM) inhibitor. COX-2/5-LOX-IN-6 displays potent anticancer activity against ovarian cancer. COX-2/5-LOX-IN-6 would not cause cytotoxic effects in noncancerous cells. COX-2/5-LOX-IN-6 is a potential anti-inflammatory agent.
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Tilmicosin phosphate (Standard)
0 ImagesCat. No.: HY-B0905ARCAS No.: 137330-13-3Synonyms: LY-177370 phosphate (Standard); EL-870 phosphate (Standard)Tilmicosin (phosphate) (Standard) is the analytical standard of Tilmicosin (phosphate). This product is intended for research and analytical applications. Tilmicosin (LY-177370) phosphate is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin phosphate mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin phosphate is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin phosphate has immunomodulatory and anti-inflammatory effects.
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(±)-Aiphanol
0 ImagesCat. No.: HY-152120CAS No.: 578020-29-8Synonyms: Aiphanol(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC50 = 1.9 μM) is particularly strong, while the effect on COX-2 (IC50= 9.9 μM) is relatively weak.(±)-Aiphanol effectively inhibits VEGFR2 (IC50=0.92 μM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active.
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Isonixin
0 ImagesCat. No.: HY-105579CAS No.: 57021-61-1Synonyms: Isonixine; NixynIsonixin (Isonixine) is a non-steroidal compound. Isonixin can be used for the research of pain and inflammation.
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LY150310 free base
0 ImagesCat. No.: HY-117019CAS No.: 103294-47-9LY150310 inhibits thromboxane synthase, cyclooxygenase, and thrombin activation. LY150310 inhibits spontaneous lung metastasis in a dose-dependent manner.
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COX-2-IN-71
0 ImagesCat. No.: HY-189395COX-2-IN-71 is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.18 μM, and shows relatively weak inhibitory activity against COX-1 with an IC50 of 65.0 μM. COX-2-IN-71 is predicted to possess favorable drug-likeness, high gastrointestinal absorption, and compliance with Lipinski's rule of five. COX-2-IN-71 can be used for research on inflammatory diseases.
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COX-2-IN-12
0 ImagesCat. No.: HY-146370CAS No.: 2986222-50-6COX-2-IN-12 (compound 3b) is a potent and selective inhibitor of COX-2 with an IC50 of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent. COX-2-IN-12 shows safety in-vivo acute toxicity study.
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Anti-inflammatory agent 71
0 ImagesCat. No.: HY-162168CAS No.: 3048402-15-6
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Anti-inflammatory agent 8
0 ImagesCat. No.: HY-115920CAS No.: 1103920-19-9
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NLRP3-IN-69
0 ImagesCat. No.: HY-170836CAS No.: 3027608-60-9
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Sabialimon P
0 ImagesCat. No.: HY-159516CAS No.: 2267333-96-8
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(+)-Catechin pentaacetate
0 ImagesCat. No.: HY-N3555CAS No.: 16198-01-9
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Anti-inflammatory agent 20
0 ImagesCat. No.: HY-146419CAS No.: 2127403-65-8Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation.
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Pelubiprofen-13C,d3
0 ImagesCat. No.: HY-12383SPelubiprofen-13C,d3 is the 13C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
