Dipeptidyl Peptidase
DPP
Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis. The dipeptidyl peptidase family, including DPP-IV DPP7, DPP8, DPP9, fibroblast activation protein and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.
DPP-IV (DPP4 or CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound enzyme, a catalytically active soluble form is detected in several body fluids. Both variants cleave off dipeptides from the N-termini of various chemokines, neuropeptides, and hormones. DPP IV plays a key role in immune-regulation, inflammation, oxidative stress, cell adhesion, and apoptosis by targeting different substrates. DPP IV inhibitors are commonly used as hypoglycemic agents.
DPP8 and DPP9 show DPPIV-like activity and share a very high-sequence similarity to each other. DPP8 and DPP9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology.
Dipeptidyl Peptidase Isoform Specific Products
All Product Categories
-
Dipeptidyl Peptidase Inhibitors
(213)
View all products
-
Dipeptidyl Peptidase Antagonist
(1)
View all products
-
Dipeptidyl Peptidase Activator
(1)
View all products
-
Dipeptidyl Peptidase Controls
(7)
View all products
-
Dipeptidyl Peptidase Substrates
(5)
View all products
-
DPP IV/CD26 Proteins
(9)
View all products
-
Dipeptidyl Peptidase Related Products (240)
Related Products (240)
-
Recombinant Proteins (9)
-
Antibodies (1)
-
Dipeptidyl Peptidase Isoform Comparison
-
Dutogliptin tartrate
0 ImagesCat. No.: HY-10286ACAS No.: 890402-81-0Synonyms: PHX-1149Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
-
Anagliptin hydrochloride
0 ImagesCat. No.: HY-14877ACAS No.: 1359670-56-6Synonyms: SK-0403 hydrochlorideAnagliptin (SK-0403) hydrochloride is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively.
-
DPP-4-IN-18
0 ImagesCat. No.: HY-Z1764CAS No.: 486460-31-5Synonyms: Sitagliptin impurity 3DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM. DPP-4-IN-18 can effectively prevent DPP-4 from degrading glucagon-like peptide 1 (GLP-1), thereby increasing the level of active GLP-1. DPP-4-IN-18 can be used for the research of type 2 diabetes.
-
(S)-Sitagliptin phosphate
0 ImagesCat. No.: HY-13749CCAS No.: 823817-58-9Synonyms: (S)-MK-0431 phosphate(S)-Sitagliptin phosphate ((S)-MK-0431 phosphate) is the S-isomer of Sitagliptin phosphate (HY-13749A). Sitagliptin phosphate (MK-0431 phosphate) is a potent DPP4 inhibitor. (S)-Sitagliptin phosphate can be used in diabetes research.
-
DPP9-IN-2
0 ImagesCat. No.: HY-179348CAS No.: 3020859-44-0DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9 ) with an IC50 of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection.
-
NVP-DPP728 dihydrochloride
0 ImagesCat. No.: HY-14293CAS No.: 207556-62-5NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.
-
PB01
0 ImagesCat. No.: HY-170572CAS No.: 368434-78-0PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively inhibits high glucose-induced ROS production and mitochondrial superoxide formation while significantly reducing cellular DPP-4 expression. PB01 can also significantly lower blood glucose levels in diabetic mice. Additionally, PB01 demonstrates good safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds potential for research in the field of diabetes.
-
ZY15557
0 ImagesCat. No.: HY-153522CAS No.: 1601480-12-9ZY15557 is a novel, competitive, long acting, orally active DPP-4 inhibitor, with a Ki of 5.53 nM. ZY15557 inhibits plasma DPP-4 activity. ZY15557 can be used in the research of type 2 diabetes.
-
RBx-0597
0 ImagesCat. No.: HY-169724CAS No.: 929105-33-9RBx-0597 is a potent and selective DPP-IV inhibitor, demonstrating IC50 values of 32, 31, and 39 nM against human, mouse, and rat plasma DPP-IV, respectively. RBx-0597 shows potential for type 2 diabetes research.
-
Evogliptin-d9 tartrate
0 ImagesCat. No.: HY-117985BSSynonyms: DA-1229-d9 tartrateEvogliptin-d9 tartrate (DA-1229-d9 tartrate) is the deuterium labeled Evogliptin tartrate (HY-117985B). Evogliptin (DA-1229) tartrate is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation.
-
Puromycin aminonucleoside (Standard)
0 ImagesPuromycin aminonucleoside (Standard) is the analytical standard of Puromycin aminonucleoside. This product is intended for research and analytical applications. Puromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models[1]. Puromycin aminonucleoside induces apoptosis[2]. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase[3]. Puromycin aminonucleoside induces secretion of cell migrasome[4].
-
KGDI-109
0 ImagesCat. No.: HY-184139CAS No.: 3027146-73-9KGDI-109 is an orally active and selective Porphyromonas gingivalis dipeptidyl peptidase 7 (PgDPP7) inhibitor with an IC50 of 53.8 µM and a Ki of 25.1 µM. KGDI-109 is also a selective antibacterial agent that suppresses Porphyromonas gingivalis growth, reduces oral Porphyromonas gingivalis levels, and suppresses alveolar bone resorption. KGDI-109 preserves gut microbial diversity. KGDI-109 can be used for the research of periodontitis.
-
Vildagliptin-d7
0 ImagesCat. No.: HY-14291S1CAS No.: 1133208-42-0Synonyms: LAF237-d7; NVP-LAF 237-d7Vildagliptin-d7 is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.
-
Antidiabetic agent 2
0 ImagesCat. No.: HY-155961CAS No.: 3052242-32-4Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase with IC50s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels.
-
ASP4000 hydrochloride
0 ImagesCat. No.: HY-111294CAS No.: 851389-35-0ASP4000 hydrochloride is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 hydrochloride reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 hydrochloride can be used in studies related to type 2 diabetes.
-
DPP-4-IN-13
0 ImagesCat. No.: HY-168621DPP-4-IN-13 (compound 9i) is a competitive DPP4 inhibitor with the IC50 of 9.25 μM and can be used for study of type 2 diabetes.
-
DPP-4/GPR119 modulator 1
0 ImagesCat. No.: HY-146468CAS No.: 2411099-68-6DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 μM. DPP-4/GPR119 modulator 1 can be used for diabetes research. DPP-4/GPR119 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
PK44
0 ImagesCat. No.: HY-103434CAS No.: 1017682-65-3PK44 (Compound 67) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 value of 15.8 nM. PK44 is promising for research of diabetes.
