D₃ Receptor Antagonist

D₃ Receptor Antagonists (37):

Cat. No.	Product Name	Effect	Purity

HY-A0077

Perphenazine	Antagonist	99.72%
Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively.

HY-103414

Raclopride	Antagonist	99.72%
Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects.

HY-19654C

(-)-GSK598809 hydrochloride	Antagonist	98.66%
(-)-GSK598809 is an isomer of GSK598809.

HY-103407

PD 168568	Antagonist
PD 168568 is a orally active and potent dopamine receptor D₄ (DRD₄) antagonist.

HY-B0274

Chlorprothixene	Antagonist	99.13%
Chlorprothixene is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.

HY-10121

Asenapine	Antagonist	99.93%
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0).

HY-14325B

L-745870 hydrochloride	Antagonist	99.91%
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM.

HY-N0096

Rotundine	Antagonist	99.87%
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively.

HY-13575

Blonanserin	Antagonist	98.73%
Blonanserin (AD-5423) is a potent and orally active 5-HT_2A (K_i=0.812 nM) and dopamine D2 receptor (K_i=0.142 nM) antagonist.

HY-B0274A

Chlorprothixene hydrochloride	Antagonist	≥98.0%
Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.

HY-10847B

SB-277011 hydrochloride	Antagonist	98.22%
SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor (D₃R) antagonist with K_i values of 10.7 nM and 11.2 nM at rodent and human D₃R, respectively.

HY-B1371A

Spiperone hydrochloride	Antagonist	99.10%
Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D₂ receptor (K_i values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors, respectively) and 5-HT_2A/5-HT_1A receptor (K_is of 1 nM/49 nM) antagonist.

HY-14782

Adoprazine	Antagonist	98.10%
Adoprazine (SLV313) is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors.

HY-17410

Iloperidone	Antagonist	99.97%
Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist.

HY-14325

L-745870	Antagonist	99.92%
L-745870 is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM.

HY-14348

GSK163090	Antagonist	99.77%
GSK163090 is a potent, selective and orally active 5-HT_1A/1B/1D receptor antagonist with pK_i values of 9.4/8.5/9.7, respectively.

HY-12697

NGB 2904	Antagonist	99.08%
NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a K_i of 1.4 nM.

HY-14541S

Olanzapine-d₃	Antagonist	98.57%
Olanzapine-d3 (LY170053-d3) is the deuterium labeled Olanzapine.

HY-10847A

SB-277011 dihydrochloride	Antagonist
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor antagonist, with pK_is of 8.0, 6.0, <5.2 and 5.9 for D₃, D₂, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-13575A

Blonanserin dihydrochloride	Antagonist
Blonanserin dihydrochloride is a potent and orally active 5-HT_2A and dopamine D2 receptor antagonist, with K_i values of 0.812 and 0.142 nM, respectively.

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