1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
  4. D3 Receptor Isoform
  5. D3 Receptor Antagonist

D3 Receptor Antagonist

D3 Receptor Antagonists (37):

Cat. No. Product Name Effect Purity
  • HY-A0077
    Perphenazine
    Antagonist 99.72%
    Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively.
  • HY-103414
    Raclopride
    Antagonist 99.72%
    Raclopride is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects.
  • HY-19654C
    (-)-GSK598809 hydrochloride
    Antagonist 98.66%
    (-)-GSK598809 is an isomer of GSK598809.
  • HY-103407
    PD 168568
    Antagonist
    PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist.
  • HY-B0274
    Chlorprothixene
    Antagonist 99.13%
    Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.
  • HY-10121
    Asenapine
    Antagonist 99.93%
    Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0).
  • HY-14325B
    L-745870 hydrochloride
    Antagonist 99.91%
    L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM.
  • HY-N0096
    Rotundine
    Antagonist 99.87%
    Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively.
  • HY-13575
    Blonanserin
    Antagonist 98.73%
    Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist.
  • HY-B0274A
    Chlorprothixene hydrochloride
    Antagonist ≥98.0%
    Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.
  • HY-10847B
    SB-277011 hydrochloride
    Antagonist 98.22%
    SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor (D3R) antagonist with Ki values of 10.7 nM and 11.2 nM at rodent and human D3R, respectively.
  • HY-B1371A
    Spiperone hydrochloride
    Antagonist 99.10%
    Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist.
  • HY-14782
    Adoprazine
    Antagonist 98.10%
    Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors.
  • HY-17410
    Iloperidone
    Antagonist 99.97%
    Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist.
  • HY-14325
    L-745870
    Antagonist 99.92%
    L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM.
  • HY-14348
    GSK163090
    Antagonist 99.77%
    GSK163090 is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7, respectively.
  • HY-12697
    NGB 2904
    Antagonist 99.08%
    NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM.
  • HY-14541S
    Olanzapine-d3
    Antagonist 98.57%
    Olanzapine-d3 (LY170053-d3) is the deuterium labeled Olanzapine.
  • HY-10847A
    SB-277011 dihydrochloride
    Antagonist
    SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
  • HY-13575A
    Blonanserin dihydrochloride
    Antagonist
    Blonanserin dihydrochloride is a potent and orally active 5-HT2A and dopamine D2 receptor antagonist, with Ki values of 0.812 and 0.142 nM, respectively.