Insulin Receptor
Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. The insulin receptor exists in two isoforms, IR-A and IR-B, expressed in different relative abundance in the various organs and tissues. The two IR isoforms have similar binding affinity for insulin but different affinity for insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B.
The insulin receptor has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.
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Insulin Receptor Inhibitors
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Insulin Receptor Agonists
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Insulin Receptor Antagonists
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Insulin Receptor Activators
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Insulin Receptor Modulators
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Insulin Receptor Inducer
(1)
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Insulin Receptor Degrader
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Insulin Receptor Substrates
(3)
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Insulin Receptor Ligand
(1)
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Insulin Receptor (INSR) Proteins
(5)
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INSR/CD220 Proteins
(7)
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Insulin Receptor Related Products (205)
Related Products (205)
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Recombinant Proteins (8)
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Antibodies (8)
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Demethylasterriquinone B1
0 ImagesSynonyms: DAQ B1; L-783281; DimethylasterriquinoneDemethylasterriquinone B1 (DAQ B1; L-783281) is an orally active insulin receptor (insulin receptor) agonist and AKT activator. By activating AKT, Demethylasterriquinone B1 upregulates the expression and activity of eNOS to increase NO production, while downregulating the expression of the NADPH oxidase subunit p22phox to reduce oxidative stress and improve vascular endothelial dysfunction in hypertensive rats. Demethylasterriquinone B1 combind with an AKT inhibitor targets the insulin signaling pathway to activate two antiviral pathways, RNA interference and JAK/STAT, in mosquitoes, thereby reducing Zika virus infection.
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PTP1B-IN-24
0 ImagesPTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT.
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Ribupatide TFA
0 ImagesCat. No.: HY-P11271APurity: 99.75%Ribupatide TFA is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Ribupatide TFA can be studied in antidiabetic research.
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Calcium mesoxalate trihydrate
0 ImagesCat. No.: HY-W540188APurity: 98.5%Synonyms: Ketomalonic acid calcium trihydrate; Mesoxalic acid calcium trihydrate; Oxomalonic acid calcium trihydrateCalcium mesoxalate trihydrate (Ketomalonic acid calcium trihydrate) is an orally active antidiabetic agent. Calcium mesoxalate trihydrate increases pancreatic insulin content. Calcium mesoxalate trihydrate reduces dietary hyperglycemia. Calcium mesoxalate trihydrate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Calcium mesoxalate trihydrate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Calcium mesoxalate trihydrate can be used in diabetes-related research.
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IRAB-B
0 ImagesCat. No.: HY-P991290Purity: 98.30%IRAB-B is a human monoclonal antibody targeting INSR. IRAB-B is an insulin receptor (IR) antagonist and can be used in the study of insulin resistance and diabetes.
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Proinsulin C-Peptide (55-89), human
0 ImagesProinsulin C-Peptide (55-89), human is a peptide fragment of the cleavage product of proinsulin.
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Semaglutide-d8 tetraTFA
0 ImagesCat. No.: HY-114118S1Purity: 99.84%Semaglutide-d8 tetraTFA is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
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GLUT4 activator 2
0 ImagesCat. No.: HY-164368CAS No.: 2761446-81-3GLUT4 activator 2 (C59) is an insulin sensitizer, which can be used for research of diabetic diseases. GLUT4 activator 2 improves glucose uptake and insulin sensitivity in rodents. GLUT4 activator 2 interacts with Unc119 and Unc119B resulting in increased insulin sensitivity and GLUT4 translocation.
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Acetyl Gastric Inhibitory Peptide (human) TFA
0 ImagesCat. No.: HY-P3580APurity: 98.42%Synonyms: Human N-acetyl GIP TFAAcetyl Gastric Inhibitory Peptide (human) TFA is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) TFA can be used for research of diabetes, insulin resistance and obesity.
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AGL-2263
0 ImagesAGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor.
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MID-1
0 ImagesMID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
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Kaempferol 3-neohesperidoside
0 ImagesSynonyms: Kaempferol 3-O-neohesperidosideKaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications.
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Mesoxalate sodium monohydrate
0 ImagesCat. No.: HY-128740CAS No.: 31635-99-1Mesoxalate sodium monohydrate is an orally active antidiabetic agent. Mesoxalate sodium monohydrate increases pancreatic insulin content. Mesoxalate sodium monohydrate reduces dietary hyperglycemia. Mesoxalate sodium monohydrate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Mesoxalate sodium monohydrate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Mesoxalate sodium monohydrate can be used in diabetes-related research.
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L-Ornithine 2-oxoglutarate
0 ImagesL-Ornithine 2-oxoglutarate (Ornithine alpha-ketoglutarate) is a nutritional compound that is a salt of amino acids with antioxidant and anti-inflammatory effects. L-Ornithine 2-oxoglutarate stimulates the production of insulin and growth hormone, and promotes intracellular amino acid transport and protein synthesis.
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Valanafusp alfa
0 ImagesSynonyms: AGT-181; HIRMAb-IDUAValanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR). Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I).
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Sequoyitol
0 ImagesSequoyitol (5-O-Methyl-myo-inositol) is an orally active hypoglycemic agent and antioxidant. Sequoyitol can be isolated from herbaceous plants. Sequoyitol downregulates the expression of NF-κB and TGF-β1, reduces ROS production and malondialdehyde levels, and enhances total antioxidant capacity. Sequoyitol activates the insulin signaling pathway, including the phosphorylation of IR, IRS1 and Akt. Sequoyitol increases serum insulin levels, inhibits hepatic glucose production, and promotes cellular glucose uptake. Sequoyitol antagonizes TNFα-induced inhibition of the insulin signaling pathway, and decreases blood urea nitrogen and serum creatinine levels. Sequoyitol elicits potential peaks in the chemosensors of adult and larval Atrophaneura alcinous, and acts as an oviposition stimulant for female Atrophaneura alcinous. Sequoyitol can be used in research related to type 2 diabetes, insulin resistance, hyperglycemia, impaired glucose tolerance and diabetic nephropathy.
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Insulin lispro
0 ImagesCat. No.: HY-109530CAS No.: 133107-64-9Insulin lispro is a recombinant human insulin analogue and is one of three rapid-acting insulin analogues available. Insulin lispro can be used for the research of hyperglycaemia in diabetes mellitus.
