MMP
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components and regulate extracellular protein turnover[1]. Mechanistically, MMPs also cleave cell-surface molecules and pericellular non-matrix proteins, thereby regulating cell behavior beyond matrix degradation[1]. In disease models, abnormal MMP and TIMP regulation contributes to inflammation, tissue destruction, fibrosis, abnormal wound repair, vascular disease, and cancer progression[2]. Compared with related isoforms, MMP-2 and MMP-9 are gelatinases, while MMP-14 is a membrane-associated MT1-MMP that supports localized pericellular matrix remodeling[3]. For experimental applications, active-MMP profiling can use batimastat affinity resin to capture active MMPs and related ADAMs for mass-spectrometry identification[3].
References:
- [1]. Sternlicht MD, et al. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. [Content Brief]
- [2]. Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739. [Content Brief]
- [3]. Chang M. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. PMID: 36825288; PMCID: PMC9942564. et al. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. [Content Brief]
All Product Categories
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MMP Related Products (446)
Related Products (446)
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Auraptene (Standard)
0 ImagesAuraptene (Standard) is the analytical standard of Auraptene. This product is intended for research and analytical applications. Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis.
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SC-44463
0 ImagesCat. No.: HY-114786CAS No.: 104408-38-0SC-44463 is a synthetic collagenase inhibitor. SC-44463 can inhibit tumor cells invasion. SC-44463 can block ovulation, inhibit action of ovarian interstitial collagenase, and inhibit action of the small metalloproteinase of the rat uterus. SC-44463 can be used for the researches of cancer and endocrinology.
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CPA 926
0 ImagesCat. No.: HY-105140CAS No.: 169673-60-3CPA 926 is a prodrug of Esculetin (HY-N0284) and is orally active. CPA 926 can inhibit the production of MMP in cartilage explants. CPA 926 can be used for the research of inflammation, such as experimental osteoarthritis.
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RJF02215
0 ImagesCat. No.: HY-169062CAS No.: 883028-78-2RJF02215 is an MMP-9 inhibitor. RJF02215 has growth-inhibitory activity on the ovarian cancer SKOV3 cell line. RJF02215 can be used for tumor research.
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SDH-IN-25
0 ImagesCat. No.: HY-172777CAS No.: 3052432-15-9SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.
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α-Solanine (Standard)
0 ImagesCat. No.: HY-N6602RCAS No.: 20562-02-1α-Solanine (Standard) is the analytical standard of α-Solanine. This product is intended for research and analytical applications. α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells.
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Doxycycline monohydrate (Standard)
0 ImagesCat. No.: HY-W008923RCAS No.: 17086-28-1Doxycycline monohydrate (Standard) is the analytical standard of Doxycycline monohydrate (HY-W008923). Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
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Antitumor agent-173
0 ImagesCat. No.: HY-161821Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety.
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Mmp8 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08556Mmp8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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C-telopeptide acetate
0 ImagesCat. No.: HY-P0284BPurity: 98.03%C-telopeptide acetate is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD). C-telopeptide acetate can be used in studies related to postmenopausal osteoporosis.
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Viridicatol (Standard)
0 ImagesCat. No.: HY-116474RCAS No.: 14484-44-7Viridicatol (Standard) is the analytical standard of Viridicatol (HY-116474). This product is intended for research and analytical applications. Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis.
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Dnp-PLGLWAr-NH2
0 ImagesCat. No.: HY-P10139CAS No.: 121282-17-5Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples.
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Anti-Human/Mouse/Bovine ADAM10 Antibody (8C7)
0 ImagesCat. No.: HY-P991857Purity: 99.50%Anti-Human/Mouse/Bovine ADAM10 Antibody (8C7) is an antibody against human, mouse, bovine ADAM10. Recommend Isotype Controls:?Rat IgG2a kappa, Isotype Control (HY-P990679).
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MMP12 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08522MMP12 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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BJ-2302
0 ImagesCat. No.: HY-182614CAS No.: 1631056-29-5BJ-2302 is a Src kinase inhibitor with an IC50 of 3.23 μM, and inhibits cathepsin S (CTSS) activity.BJ-2302 binds to Src, suppresses PI3K/AKT and Ras/Raf/ERK pathways, and reduces CTSS and MMP-9 expression.BJ-2302 inhibits cancer cell invasion, metastasis, proliferation, and tumor growth.BJ-2302 does not induce cytotoxicity in normal breast epithelial cells.BJ-2302 can be used for the research of breast cancer and triple-negative breast cancer.
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MT5-MMP-IN-1
0 ImagesCat. No.: HY-184183MT5-MMP-IN-1 is a non-peptidic MT5-MMP (MMP-24) inhibitor with an IC50 of 6 μM. MT5-MMP-IN-1 interacts with the catalytic zinc ion of MT5-MMP via a hydroxamic acid zinc-binding group. MT5-MMP-IN-1 is applicable to the research of Alzheimer's disease.
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FN-439
0 ImagesCat. No.: HY-100210CAS No.: 124168-73-6FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation.
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Mmp14 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08529Mmp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
