PROTACs
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PROTACs Related Products (436)
Related Products (436)
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PROTAC SOS1 degrader-1
0 ImagesCat. No.: HY-145737CAS No.: 2913185-35-8PROTAC SOS1 degrader-1 is a degrader of SOS1 PROTAC, with a DC50 of 98.4 nM and a Kd value of 44 nM. PROTAC SOS1 degrader-1 induces the formation of a ternary complex with SOS1 and the VCB E3 ubiquitin ligase complex, thereby promoting the ubiquitination and proteasomal degradation of SOS1. PROTAC SOS1 degrader-1 reduces KRAS-GTP levels, inhibits the phosphorylation of ERK in the RAS-RAF-MEK-ERK pathway, and suppresses the proliferation of cancer cells carrying KRAS mutations. PROTAC SOS1 degrader-1 inhibits tumor growth in mouse xenograft models. PROTAC SOS1 degrader-1 can be used for the research of KRAS-driven cancers.
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PROTAC PXR degrader-1
0 ImagesCat. No.: HY-169279PROTAC PXR degrader-1 is a PROTAC degrader targeting PXR, with a DC50 value of 49.8 nM in SNU-C4 3xFLAG-PXR KI cells. PROTAC PXR degrader-1 exhibits selectivity towards CAR, VDR, FXR, LXRα and LXRβ. PROTAC PXR degrader-1 induces the formation of a ternary complex with PXR and VHL, triggering proteasomal degradation of PXR. PROTAC PXR degrader-1 reduces both agonist-induced and basal PXR-mediated CYP3A4 promoter activation, and decreases the expression of endogenous CYP3A4 gene in cancer cells. PROTAC PXR degrader-1 enhances the cytotoxic effect of paclitaxel on cancer cells. PROTAC PXR degrader-1 can be used for the research of colorectal cancer.
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PROTAC Aster-A degrader-1
0 ImagesCat. No.: HY-D2336CAS No.: 3038774-43-2PROTAC Aster-A degrader-1 is a PROTAC degrader targeting the sterol transporter (Aster-A), with a DC50 of 4.8 μM. PROTAC Aster-A degrader-1 binds to the sterol-binding domain of Aster-A, with a FI-Kd value of 83 nM. PROTAC Aster-A degrader-1 induces CRL- and proteasome-dependent degradation of Aster-A and inhibits autophagy in cancer cells. PROTAC Aster-A degrader-1 serves as a fluorescent probe. PROTAC Aster-A degrader-1 is useful for research related to cervical cancer, breast cancer, and lung adenocarcinoma.
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PROTAC NAMPT Degrader-32
0 ImagesCat. No.: HY-155506PROTAC NAMPT Degrader-32 is a PROTAC degrader targeting NAMPT with an IC50 of 2.14 nM. PROTAC NAMPT Degrader-32 induces proteasome-dependent degradation of NAMPT and induces apoptosis in ovarian cancer cells (apoptosis). PROTAC NAMPT Degrader-32 can be used in research related to ovarian cancer.
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PROTAC ALK5 Degrader-1
0 ImagesCat. No.: HY-183785CAS No.: 3125240-35-6PROTAC ALK5 Degrader-1 is a selective ALK5 PROTAC degrader. PROTAC ALK5 Degrader-1 induces ALK5 degradation via ALK5 ATP-binding pocket engagement, CRBN recruitment, and the ubiquitin-proteasome system.PROTAC ALK5 Degrader-1 inhibits ALK5 downstream signaling. PROTAC ALK5 Degrader-1 can be used for the research of pulmonary fibrosis.
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AY-4
0 ImagesCat. No.: HY-174867CAS No.: 3091513-13-9AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (Kd = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe2+) and ferric (Fe3+) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871); Blue: E3 ligand Pomalidomide (HY-10984); Black: Linker, Pomalidomide-PEG3-acid (HY-174872)).
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CaMKIIα-PHOTAC
0 ImagesCat. No.: HY-156104CAS No.: 2481744-33-4CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains.
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PROTAC RTA Degrader-1
0 ImagesCat. No.: HY-181705PROTAC RTA Degrader-1 (Compound 3A) is a ricin toxin A chain (RTA) PROTAC degrader. PROTAC RTA Degrader-1 forms stable ternary complexes, maintains sustained hydrogen bonding interactions, and exhibits distinct interaction energy. PROTAC RTA Degrader-1 is applicable to research related to ricin toxin poisoning.
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PROTAC BTK Degrader-3
0 ImagesCat. No.: HY-153536CAS No.: 2563861-90-3
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PROTAC EZH2 Degrader-40
0 ImagesCat. No.: HY-181409CAS No.: 3093642-40-8PROTAC EZH2 Degrader-40 (compound 56) is a PROTAC protein degrader targeting EZH2 with an IC50 of 15.35 μM against SU-DHL-6 cells. PROTAC EZH2 Degrader-40 can be used for the research of diffuse large B-cell lymphoma.
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ISM-PR44
0 ImagesCat. No.: HY-189442ISM-PR44 is an orally active PROTAC degrader targeting BTK, with a DC50 of 0.05 nM in BTK-HiBiT Ramos cells. ISM-PR44 recruits CRBN E3 ligase to induce ubiquitination and proteasomal degradation of BTK. ISM-PR44 exhibits antiproliferative and cytotoxic activities in B-cell lymphoma cells. ISM-PR44 can be used for research on B-cell lymphoma.
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BI-0319
0 ImagesCat. No.: HY-176198CAS No.: 2341740-85-8BI-0319 is a potent and selective PTK2 (FAK) PROTAC degrader with an IC50 of 19 nM and a DC50 of 243 nM (in A549 cells). By bridging PTK2 and VHL E3 ubiquitin ligase, BI-0319 induces polyubiquitination of PTK2, leading to its targeted degradation via the ubiquitin-proteasome system. BI-0319 can be used in research related to liver cancer and non-small cell lung cancer.
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ML 2-23
0 ImagesCat. No.: HY-153582ML 2-23 is a PROTAC degrader that recruits RNF114 to target BCR-ABL/c-ABL for degradation. ML 2-23 promotes proteasome-dependent degradation of the target protein and inhibits phosphorylation of downstream CRKL. At concentrations used for BCR-ABL degradation, ML 2-23 only causes slight impairment to the viability of cancer cells. ML 2-23 can be used in the research of chronic myeloid leukemia.
