Parasite
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.
Parasite Isoform Specific Products
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Parasite Related Products (2548)
Related Products (2548)
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Related Compound Screening Libraries (1)
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Parasite Isoform Comparison
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Δ2-Avermectin B1a
0 ImagesCat. No.: HY-15308BCAS No.: 110415-68-4Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent targeting glutamate-gated chloride channels (GluCls) in the neuromuscular system of invertebrates. Δ²-Avermectin B₁ₐ enhances chloride ion influx, leading to hyperpolarization of the neuromuscular cell membrane, inhibition of neural signal transmission, and ultimately paralysis and death of parasites. Δ²-Avermectin B₁ₐ is promising for research of agricultural pests.
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Celangulatin C
0 ImagesCat. No.: HY-N10695CAS No.: 1000784-44-0Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows LD50 against Mythimna separata of 280.4 μg/mL.
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Halofuginone hydrochloride (Standard)
0 ImagesCat. No.: HY-N1584BRCAS No.: 1217623-74-9Synonyms: RU-19110 hydrochloride (Standard)Halofuginone hydrochloride (Standard) (RU-19110 hydrochloride (Standard)) is the analytical standard of Halofuginone hydrochloride (HY-N1584B). This product is intended for research and analytical applications. Halofuginone hydrochloride (RU-19110 hydrochloride), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrochloride is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrochloride is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrochloride has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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Clofentezine-d8
0 ImagesCat. No.: HY-W718785CAS No.: 2732862-38-1Clofentezine-d8 is the deuterium labeled Clofentezine (HY-B2066). Clofentezine is a growth inhibitor that is highly lethal to mites.
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Sulfadiazine-13C6
0 ImagesSulfadiazine-13C6 is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is an orally active sulfonamide antibiotic. Sulfadiazine competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine targets Toxoplasma gondii DHPS enzyme. Sulfadiazine can be used for the research of congenital toxoplasmosis and bacterial infection.
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Antileishmanial agent-8
0 ImagesCat. No.: HY-147536CAS No.: 2477608-96-9Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC50=73.9 μM).
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JPC-3210
0 ImagesCat. No.: HY-117599CAS No.: 1609655-35-7JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC50 ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention.
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Penicolinate B
0 ImagesCat. No.: HY-N12230CAS No.: 1418291-70-9Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candida albicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors.
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NPD8790
0 ImagesCat. No.: HY-158423CAS No.: 615281-26-0NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths.
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Catechu extract
0 ImagesCat. No.: HY-N20283Catechu extract is an extract of catechu (Areca catechu L.) that can be used in research on parasitic diseases and depression.
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Antileishmanial agent-44
0 ImagesCat. No.: HY-184214Antileishmanial agent-44 is a histone deacetylase inhibitor targeting Leishmania donovani Sir2, with an IC50 of 0.652 μM against amastigotes. Antileishmanial agent-44 elevates ROS levels to induce oxidative stress, which causes mitochondrial membrane potential depolarization, cytochrome c release, phosphatidylserine externalization and DNA fragmentation, triggers apoptosis-like cell death, and arrests the cell cycle. Antileishmanial agent-44 upregulates the expression of Th1-type cytokines and NO in macrophages, reshapes host immune responses to eliminate intracellular parasites. Antileishmanial agent-44 inhibits parasites in infected golden hamsters in vivo. Antileishmanial agent-44 can be used for the research of visceral leishmaniasis.
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Phebestin
0 ImagesCat. No.: HY-122248CAS No.: 187402-73-9Phebestin is a compound with antimalarial activity that has an inhibitory effect on Plasmodium and has shown good results in in vitro and in vivo experiments. It can also bind to related enzymes of Plasmodium.
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PIM-IN-3
0 ImagesCat. No.: HY-178979CAS No.: 3082559-91-6PIM-IN-3 (Compound 50) is an orally active new anti-intestinal worm drug. PIM-IN-3 exhibits strong inhibitory activity in vitro, especially for whipworms (IC50 = 6.6 µM). PIM-IN-3 has low cytotoxicity. PIM-IN-3 can be used in the research of gastrointestinal nematode diseases.
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Acetylastragaloside I
0 ImagesCat. No.: HY-N1985CAS No.: 84687-47-8Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection.
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Negundoside
0 ImagesCat. No.: HY-182295CAS No.: 82451-20-5Negundoside is an iridoid glycoside compound. Negundoside exhibits hepatoprotective effects, reduces ROS, lipid peroxidation and intracellular calcium ion levels, and prevents the decrease of mitochondrial membrane potential (MMP) and apoptosis (apoptosis). Negundoside has neuroprotective effects, improves behavioral deficits, alleviates oxidative damage, and ameliorates cerebral infarction. Negundoside also possesses antibacterial and antiparasitic activities.
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Naloxonazine
0 ImagesCat. No.: HY-137180CAS No.: 82824-01-9Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function.
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(Rac)-Efavirenz
0 ImagesCat. No.: HY-10572BCAS No.: 177530-93-7Synonyms: (Rac)-DMP 266; (Rac)-EFV; (Rac)-L-743726
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Rabdosiae rubescentis herba extract
0 ImagesCat. No.: HY-N20422Synonyms: Rabdosia rubescens extractRabdosiae rubescentis herba extract (Rabdosia rubescens extract) is an extract of Rabdosia rubescens (Hemsl.) Hara, which has various biological activities such as antibacterial, antiparasitic, anti-inflammatory and anticancer effects.
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M&B 5124
0 ImagesCat. No.: HY-131508CAS No.: 15382-90-8M&B 5124 is a potent inhibitor of Schistosoma mansoni in mice.
