RAR/RXR
Retinoic acid receptors; Retinoid X receptors
The nuclear retinoic acid receptors (RARs) are transcriptional transregulators, which control the expression of specific gene subsets subsequently to ligand binding and to strictly controlled phosphorylation processes. RARs consist of three subtypes, α (NR1B1), β (NR1B2) and γ (NR1B3), encoded by separate genes. RARs function as ligand-dependent transcriptional regulators, heterodimerized with retinoid X receptors (RXRs), which also consist of three types, α NR2B1, β (NR2B2) and γ (NR2B3). RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, organogenesis and homeostasis, as assessed by vitamin A-deficiency (VAD), pharmacological and genetic studies conducted in the mouse.
Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function.
RAR/RXR Isoform Specific Products
All Product Categories
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RAR/RXR Related Products (216)
Related Products (216)
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Antibodies (1)
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RAR/RXR Isoform Comparison
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Fenretinide (Standard)
0 ImagesSynonyms: 4-HPR (Standard); ISLA-101 (Standard)Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
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GW0791
0 ImagesCat. No.: HY-119574CAS No.: 503620-39-1
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(all-E)-UAB30
0 ImagesCat. No.: HY-117376CAS No.: 205252-59-1Synonyms: UAB30(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively.
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BMS-185354
0 ImagesCat. No.: HY-173159CAS No.: 110952-22-2BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM. BMS-185354 is promising for research of cancers.
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AGN 191701
0 ImagesCat. No.: HY-117926CAS No.: 156691-84-8AGN 191701 is a selective retinoic acid X receptor (RXR) agonist that causes liver enlargement in rats without hepatocellular necrosis.
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Nurr1/RXR agonist 1
0 ImagesNurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC50 = 2.6 µM) and RXR with Ks of 0.6 and 1.1 µM, respectively. Nurr1/RXR dual agonist 1 exclusively activates the heterodimer response element DR5 by selectively destabilizing the Nurr1 homodimer and stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR dual agonist 1 enhances expression of a specific subset of neuroprotective Nurr1 target genes while avoiding induction of genes associated with potential off-target effects in neuronal cells. Nurr1/RXR dual agonist 1 can be used for neurodegenerative diseases research.
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Adapalene (Standard)
0 ImagesSynonyms: CD271 (Standard)Adapalene (Standard) is the analytical standard of Adapalene. This product is intended for research and analytical applications. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.
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Trifarotene (Standard)
0 ImagesSynonyms: CD5789 (Standard)Trifarotene (Standard) is the analytical standard of Trifarotene. This product is intended for research and analytical applications. Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ∼65-fold and ∼16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM), respectively.
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11-cis-Retinoic Acid-d5
0 ImagesCat. No.: HY-14649S211-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
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CD3254 (Standard)
0 ImagesCat. No.: HY-107399RCAS No.: 196961-43-0
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Viaminate (Standard)
0 ImagesCat. No.: HY-112077ARCAS No.: 53839-71-7Viaminate (Standard) is the analytical standard of Viaminate. This product is intended for research and analytical applications. Viaminate is a derivative of Retinoic acid, which is used for the treatment of severe acne and other keratinization disorders.
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β-Apo-13-carotenone (Standard)
0 ImagesCat. No.: HY-101953RCAS No.: 17974-57-1Synonyms: D'Orenone (Standard)β-Apo-13-carotenone (Standard) is the analytical standard of β-Apo-13-carotenone (HY-101953). This product is intended for research and analytical applications. β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
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BMS 753 (Standard)
0 ImagesCat. No.: HY-107395RCAS No.: 215307-86-1
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JP3000
0 ImagesCat. No.: HY-160212CAS No.: 3034097-74-7JP3000, a chemical probe, is an agonist of RXRA, RXRB, RXRG.
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Magnolol (Standard)
0 ImagesMagnolol (Standard) is the analytical standard of Magnolol. This product is intended for research and analytical applications. Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
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AGN 190727
0 ImagesCat. No.: HY-118364CAS No.: 115503-91-8AGN 190727 is a structural isomer of AGN 190121 and has no activating effect on RAR/RXR. AGN 190121 is a RAR-specific agonist that causes a dose-dependent increase in serum triglycerides, leading to hypertriglyceridemia.
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PA452 (Standard)
0 ImagesCat. No.: HY-108522RCAS No.: 457657-34-0
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AR7 (Standard)
0 ImagesCat. No.: HY-101106RCAS No.: 80306-38-3AR7 (Standard) is the analytical standard of AR7 (HY-101106). This product is intended for research and analytical applications. AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
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(E)-XS-060
0 ImagesCat. No.: HY-149085ACAS No.: 2787626-06-4
