Reference Standards
Material, sufficiently homogeneous and stable with respect to one or more specified properties, and the uses include the calibration of a measurement system, assessment of a measurement procedure, assigning values to other materials, and quality control and so on.
-
Reference Standards Produits associés (11771)
Produits associés (11771)
-
(S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid (Standard)
0 ImagesCat. No.: HY-59135RCAS No.: 162537-11-3(S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid (Standard) is the analytical standard of (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid. This product is intended for research and analytical applications. (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid is a leucine derivative.
-
STAT5-IN-1 (Standard)
0 ImagesSTAT5-IN-1 (Standard) is the analytical standard of STAT5-IN-1 (HY-101853). This product is intended for research and analytical applications. STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
-
Tivozanib (Standard)
0 ImagesSynonyms: AV-951 (Standard); KRN951 (Standard)Tivozanib (Standard) is the analytical standard of Tivozanib. This product is intended for research and analytical applications. Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy.
-
GKT136901 hydrochloride (Standard)
0 ImagesGKT136901 (hydrochloride) (Standard) is the analytical standard of GKT136901 (hydrochloride). This product is intended for research and analytical applications. GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
-
Azeliragon (Standard)
0 ImagesSynonyms: TTP488 (Standard); PF-04494700 (Standard)Azeliragon (Standard) is the analytical standard of Azeliragon. This product is intended for research and analytical applications. Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB).
-
KL001 (Standard)
0 ImagesCat. No.: HY-108468RCAS No.: 309928-48-1KL001 (Standard) is the analytical standard of KL001 (HY-108468). This product is intended for research and analytical applications. KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis.
-
Crinecerfont (Standard)
0 ImagesSynonyms: SSR-125543 (Standard)Crinecerfont (Standard) is the analytical standard of Crinecerfont (HY-106203). This product is intended for research and analytical applications. Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
Regadenoson (Standard)
0 ImagesSynonyms: CVT-3146 (Standard)Regadenoson (Standard) is the analytical standard of Regadenoson. This product is intended for research and analytical applications. Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS.
-
KH7 (Standard)
0 ImagesCat. No.: HY-103194RCAS No.: 330676-02-3KH7 (Standard) is the analytical standard of KH7 (HY-103194). This product is intended for research and analytical applications. KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.
-
Penicillamine (Standard)
0 ImagesPenicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
-
Almitrine mesylate (Standard)
0 ImagesSynonyms: Almitrine bismesylate (Standard); Almitrine bismethanesulfonate (Standard); Almitrine dimesylate (Standard)Almitrine mesylate (Standard) (Almitrine bismesylate (Standard)) is the analytical standard of Almitrine mesylate (HY-107319). This product is intended for research and analytical applications. Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.
-
Niraparib tosylate hydrate (Standard)
0 ImagesCat. No.: HY-10619ERCAS No.: 1613220-15-7Synonyms: MK-4827 tosylate hydrate (Standard)Niraparib tosylate hydrate (Standard) is the analytical standard of Niraparib tosylate hydrate (HY-10619E). This product is intended for research and analytical applications. Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.
-
N-(3-Chloro-4-hydroxyphenyl)acetamide (Standard)
0 ImagesCat. No.: HY-W042159RCAS No.: 3964-54-3N-(3-Chloro-4-hydroxyphenyl)acetamide (Standard) is the analytical standard of N-(3-Chloro-4-hydroxyphenyl)acetamide. This product is intended for research and analytical applications.
-
Ensartinib dihydrochloride (Standard)
0 ImagesCat. No.: HY-103714ARCAS No.: 2137030-98-7Synonyms: X-396 dihydrochloride (Standard)Ensartinib dihydrochloride (Standard) is the analytical standard of Ensartinib dihydrochloride (HY-103714A). This product is intended for research and analytical applications. Ensartinib dihydrochloride (X-396 dihydrochloride) is a BBB-permeable and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
-
2-NP-AMOZ (Standard)
0 ImagesCat. No.: HY-136456RCAS No.: 183193-59-12-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
-
Siponimod (Standard)
0 ImagesSynonyms: BAF-312 (Standard)Siponimod (BAF-312) (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.
-
HPGDS inhibitor 1 (Standard)
0 ImagesCat. No.: HY-10439RCAS No.: 1033836-12-2HPGDS inhibitor 1 (Standard) is the analytical standard of HPGDS inhibitor 1 (HY-10439). This product is intended for research and analytical applications. HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX.
-
CZC-8004 (Standard)
0 ImagesCat. No.: HY-111138RCAS No.: 916603-07-1Synonyms: CZC-00008004 (Standard)CZC-8004 (Standard) is the analytical standard of CZC-8004 (HY-111138). This product is intended for research and analytical applications. CZC-8004 (CZC-00008004) is a pan-Kinase inhibitor. CZC-8004 has IC50 values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer.
-
ACY-1083 (Standard)
0 ImagesCat. No.: HY-111791RCAS No.: 1708113-43-2ACY-1083 (Standard) is the analytical standard of ACY-1083 (HY-111791). This product is intended for research and analytical applications. ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.
