SIRT1 Inhibitor

hsa62 is a dual inhibitor for SIRT1 and SIRT2, with IC₅₀ of 1.3 and 5.5 μM, respectively.

Sirt1/CXCR3-IN-1 is a dual Sirt1/CXCR3 inhibitor with an IC₅₀ of 0.77 μM against Sirt1. Sirt1/CXCR3-IN-1 inhibits dengue virus replication, upregulates the expression of interferon-stimulated genes, and enhances the antiviral defense capacity of the host. Sirt1/CXCR3-IN-1 suppresses CXCR3-mediated T cell chemotaxis and cytokine release, thereby reducing immune activation and inflammatory responses. Sirt1/CXCR3-IN-1 is applicable to research related to dengue virus infection.

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀ of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.

Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC₅₀s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma.

Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC₅₀ value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer.

SIRT1-IN-5 (215) is a NAD-dependent protein deacetylase sirtuin-1 modulator.

SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC₅₀ of 0.196 μM.

SIRT1-IN-7 is a weak inhibitor of SIRT1 with an IC₅₀ > 100 μM. SIRT1-IN-7 can be used in cancer-related research, such as breast cancer research.

Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3β, β-catenin, and TGF-3β expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-κB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-α, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimer’s disease, and rheumatoid arthritis.

SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC₅₀ of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC₅₀ of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models.

ZINC08792229 is a potent SIRT1 inhibitor. ZINC08792229 has the potential for research on SIRT1 related diseases, such as ageing, diabetes, cancers.

SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC₅₀ values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders.

2-(2-Thienyl) benzofuran is a SIRT1 inhibitor with an inhibition rate of up to 63.6%. 2-(2-Thienyl) benzofuran inhibits the proliferation of breast cancer cells, and its antiproliferative activity is comparable to that of Suramin (HY-B0879). 2-(2-Thienyl) benzofuran can be used in breast cancer-related research.

2"-O-Galloylhyperin (Standard) is the analytical standard of 2"-O-Galloylhyperin (HY-N0526). This product is intended for research and analytical applications. 2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates SIRT1/Nrf2 signaling, inhibits NF-κB and MAPK (ERK1/2, p38, JNK) phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease.