TRP Channel
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TRP Channel Related Products (342)
Related Products (342)
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Pregnenolone monosulfate sodium (Standard)
0 ImagesCat. No.: HY-110189RCAS No.: 1852-38-6Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium (Standard)Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
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TC-I 2014 (Standard)
0 ImagesCat. No.: HY-110199RCAS No.: 1221349-53-6TC-I 2014 (Standard) is the analytical standard of TC-I 2014 (HY-110199). This product is intended for research and analytical applications. TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.
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8-Br-7-CH-ADPR
0 ImagesCat. No.: HY-134268CAS No.: 1011457-95-6Synonyms: 8-Bromo-7-deazaadenosine-5'-O-diphosphoribose8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.
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AM-0902 (Standard)
0 ImagesCat. No.: HY-108329RCAS No.: 1883711-97-4
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MSK-195
0 ImagesCat. No.: HY-123428CAS No.: 289902-82-5MSK-195 is a potent agonist of TRPV1, with a potency of 120 nM and an efficacy of 71% in arteriolar response.
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Mesendogen (Standard)
0 ImagesCat. No.: HY-103073RCAS No.: 864716-85-8Mesendogen (Standard) is the analytical standard of Mesendogen (HY-103073). This product is intended for research and analytical applications. Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development.
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A778317
0 ImagesCat. No.: HY-121122CAS No.: 808756-64-1
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HC-067047 (Standard)
0 ImagesHC-067047 (Standard) is the analytical standard of HC-067047 (HY-100208). This product is intended for research and analytical applications. HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
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Cyclo(-asp-gly)
0 ImagesCat. No.: HY-W554764CAS No.: 52661-97-9Cyclo(-asp-gly) is a cyclic dipeptide composed of amino acids and is a potential TRPV1 stimulator.
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MK6-83 (Standard)
0 ImagesCat. No.: HY-110238RCAS No.: 1062271-24-2
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BI-749327 (Standard)
0 ImagesCat. No.: HY-111925RCAS No.: 2361241-23-6BI-749327 (Standard) is the analytical standard of BI-749327 (HY-111925). This product is intended for research and analytical applications. BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.
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Clemizole penicillin
0 ImagesCat. No.: HY-W754356CAS No.: 6011-39-8Clemizole penicillin is a composite preparation containing two active components, Clemizole (HY-30234) and penicillin, with antihistamine, anti-inflammatory, and bactericidal activities. The Clemizole component of Clemizole penicillin targets the H1 receptor, CrtN, and TRPC5 calcium channel, while penicillin exerts antibacterial effects. The clemizole contained in Clemizole penicillin acts as a reversible competitive inhibitor of the TRPC5 calcium channel; it also competitively targets the CrtN enzyme of Staphylococcus aureus to block staphyloxanthin biosynthesis. Clemizole penicillin can be used in research on lobar pneumonia and syphilis.
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JT010 (Standard)
0 ImagesCat. No.: HY-111132RCAS No.: 917562-33-5JT010 (Standard) is the analytical standard of JT010 (HY-111132). This product is intended for research and analytical applications. JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research.
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SB 452533 (Standard)
0 ImagesCat. No.: HY-108458RCAS No.: 459429-39-1SB 452533 (Standard) is the analytical standard of SB 452533 (HY-108458). This product is intended for research and analytical applications. SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8.
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AMG2850 (Standard)
0 ImagesCat. No.: HY-104059RCAS No.: 1470018-52-0AMG2850 (Standard) is the analytical standard of AMG2850 (HY-104059). This product is intended for research and analytical applications. AMG2850 is an orally active, blood-brain barrier-permeable selective TRPM8 competitive antagonist. AMG2850 abolishes the counterirritant effect of TRPM8 agonists, blocks TRPM8 activation induced by cold, (-)-Menthol (HY-75161) and Icilin (HY-11062), and exhibits selectivity over TRPA1, TRPV1, TRPV3 and TRPV4. AMG2850 is applicable for pain-related research.
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JYL-79
0 ImagesCat. No.: HY-117922CAS No.: 289902-64-3
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TRPV3 modulator-1
0 ImagesCat. No.: HY-186008CAS No.: 311789-03-4
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Probenecid-d7
0 ImagesCat. No.: HY-B0545S1CAS No.: 2012598-90-0
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JYL 1421 (Standard)
0 ImagesSynonyms: SC 0030 (Standard)
