1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. SB 452533

SB 452533 

Cat. No.: HY-108458
Handling Instructions

SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8.

For research use only. We do not sell to patients.

SB 452533 Chemical Structure

SB 452533 Chemical Structure

CAS No. : 459429-39-1

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Description

SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8[1].

In Vitro

SB 452533 is potent as an antagonist at the cloned recombinant rat TRPV1 receptor in HEK293 cells with a pKb of 7.7 and a pIC50 of 7.0[1].
SB-452533 reduces phosphorylation of CAMKK2 and AMPK[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Skeletal muscle (C2C12) cells
Concentration: 0, 50, 100, 200, and 400 μM
Incubation Time: 30 minutes; followed by 200 μM Capsaicin treatment for another 30 min.
Result: Significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2.
In Vivo

Capsaicin (Cap; small dose 2 mg/kg) significantly reduces Bleomycin-induced pulmonary fibrosis in mice. SB-452533 abolishes the effects of small dose Cap[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice bearing pulmonary fibrosis model[3]
Dosage: 2.5 mg/kg
Administration: Treatment received daily drug via subcutaneous injection for 21 days
Result: The effect (reduced Bleomycin-induced pulmonary fibrosis) of Cap were abolished in the presence of SB-452533.
Molecular Weight

376.29

Formula

C₁₈H₂₂BrN₃O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SB 452533
Cat. No.:
HY-108458
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