Beta-lactamase Inhibitor

NDM-1 inhibitor-5 (compound 57) is a potent NDM-1 inhibitor, with a K_i of 2.5 μM. NDM-1 inhibitor-5 also shows antibacterial synergistic activity with meropenem (HY-13678).

LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC₅₀ for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs.

AM-112 is a β-lactamase (β-lactamase) inhibitor and antibacterial agent, with IC₅₀ values ranging from 0.0002 μg/mL to 0.67 μg/mL against class A, C, and D β-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections.

Carpetimycin D has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin D has a strong inhibitory effect on β-lactamase.

Pracinostat (Standard) is the analytical standard of Pracinostat. This product is intended for research and analytical applications. Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM.

Avibactam (free acid) (Standard) is the analytical standard of Avibactam (free acid). This product is intended for research and analytical applications. Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

Izumenolide is found in the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC₅₀ concentration of TEM-2 β-lactamase was 0.01 μg/mL.

NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC₅₀ of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models.

BAL-0019764 is an iron carrier monocyclic β-lactam with broad-spectrum β-lactase inhibition ability. BAL-0019764 has inhibitory activity against various Gram negative bacteria. BAL-0019764 is commonly used in the study of bacterial infections.

β-Lactamase-IN-11 is a β-Lactamase Inhibitor with an IC₅₀ of 30.37 μM. β-Lactamase-IN-11 exhibits significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, demonstrating potential for combating various drug-resistant bacteria. β-Lactamase-IN-11 can be used for studying infections caused by enzyme-producing drug-resistant bacteria.

Carpetimycin B has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin B has a strong inhibitory effect on β-lactamase.

Cefditoren Pivoxil (Standard) is the analytical standard of Cefditoren Pivoxil. This product is intended for research and analytical applications. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

Dotriacolide is a β-actamase inhibitor. Dotriacolide has significant inhibitory activities against both penicillinase and cephalosporinase with ID₅₀ values of 0.61 μg/mL and 0.15 μg/mL, respectively. Dotriacolide is promising for research of infectious diseases.

2'-Hydroxybiphenyl-3-carboxylic acid is a β-lactamase oxa-48 inhibitor (IC₅₀ = 50 µM; K_d = 1750 µM) .

D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC₅₀ value of 21.8 µM against NDM-1 and a K_i of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd²⁺ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections.

Cefonicid monosodium is a long-acting cephalosporin antibiotic. Cefonicid monosodium also acts as a noncompetitive class I β-lactamase inhibitor with a K_i value of 0.8 μM. Cefonicid monosodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid monosodium can be used for research on infections.

Relebactam-d₉ (MK-7655-d₉) is deuterium labeled Relebactam. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.

Cefotaxime-d₃ (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.

Carpetimycin A has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin A has a strong inhibitory effect on β-lactamase.

BLI-489 Standard is the analytical standard of BLI-489 (HY-108062). This product is intended for research and analytical applications. BLI-489 is a Beta-lactamase inhibitor. BLI-489 is an antibacterial adjuvant that significantly enhances the antibacterial efficacy of β-lactam antibiotics. BLI-489 blocks the hydrolytic activity of the enzyme by forming a stable intermediate in serine Beta-lactamase, or by coordinating with the binuclear Zn²⁺ through an oxygen atom in metallo-Beta-lactamase. BLI-489 can be used for research on bacterial infections.