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Z-IETD-FMK

(Synonyms: Z-IE(OMe)TD(OMe)-FMK)
73 Cited Publications
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Based on 73 publication(s) in Google Scholar

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor.

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  • Pureté : ≥98.0%
  • CAS No.: 210344-98-2
  • Formule: C30H43FN4O11
  • Masse moléculaire:654.68
  • Stockage:

    Sealed storage, away from moisture.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Z-IETD-FMK Chemical Structure
    Z-IETD-FMK Chemical Structure
  • Experimental Validation Results for Z-IETD-FMK
  • Experimental Validation Results for Z-IETD-FMK
  • Experimental Validation Results for Z-IETD-FMK
  • Experimental Validation Results for Z-IETD-FMK
  • Experimental Validation Results for Z-IETD-FMK
  • Experimental Validation Results for Z-IETD-FMK
CAS No.: 210344-98-2
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2D/3D Cell Culture and DifferentiationWBCell Imaging/Staining
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  • Z-IETD-FMK Chemical Structure
    Z-IETD-FMK Chemical Structure
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  • 1/16

    Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Jun 17;16(1):452. [Abstract]

    Customer Validation
     Representative phase-contrast images of pyroptotic cell death induced by RG7388 in H23 cells pretreated with or without pan-caspase inhibitor Z-VAD-FMK (zVAD, 50 μM), caspase-8 inhibitor Z-IETD-FMK (Cas8i, 50 μM) or caspase-3 inhibitor Z-DEVD-FMK (Cas3i, 25 μM) as indicated for 6 hours

  • 1/16

    Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell. 2024 Dec 26;187(26):7533-7550.e23. [Abstract]

    Customer Validation
     Organoids were treated with Z-IETD-FMK (Z-IETD, 40 μM, 16 h) during rIFN-λ treatment.

  • 1/16

    Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]

    Customer Validation
     THP-1 monocytes were pretreated for 0.5 h with DMSO or Z-IETD-FMK (25 μM) and stimulated for 6 h with heat-killed gram-negative bacteria at twice the number of cells. Immunoblots showing caspase-8, caspase-1 and IL-1β in total cell lysate are representative of one of two experimental repeats.

  • 1/16

    Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]

    Customer Validation
     PBMCs were pretreated for 0.5 h with DMSO or Z-IETD-FMK (25 μM) and stimulated for 16 h with heat-killed gram-negative bacteria at twice the number of monocytes.

  • 1/16

    Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]

    Customer Validation
     THP-1 monocytes were pretreated for 0.5 h with DMSO or Z-IETD-FMK (25 μM) and stimulated at a specific time point with heat-killed E. coli XL10 at twice the number of cells. Immunoblots showing P-TAK1, caspase-8 and caspase-1 in total cell lysate are representative of one of two experimental repeats.

  • 1/16

    Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2018 Oct:120:143-154. [Abstract]

    Customer Validation
     Z-IETD-FMK remarkably decreases the dioscin-induced up regulation of Caspase-3

  • Z-IETD-FMK