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Cat. No.: HY-182766

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AMX-883

AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML).

For research use only. We do not sell to patients.

CAS No.: 3102636-19-8
Formula: C₄₅H₅₈FN₅O₅
Molecular Weight:767.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AMX-883 Chemical Structure

CAS No.: 3102636-19-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

BRD9

All Epigenetic Reader Domain Isoforms :

In Vitro

Combination of AMX-883 with Venetoclax (HY-15531) resulted in synergistic efficacy in MV4-11 and MOLM-13 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AMX-883 (14 days) induced dose-dependent degradation of BRD9 in a luciferase-labeled MV4-11 dissemination model, accompanied by time-dependent induction of CD11b and CD86. Measurements of total disease burden in animals showed a significant reduction in tumor burden in the AMX-883-treated groups compared to the vector control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3102636-19-8
Molecular Weight 767.97
Formula C₄₅H₅₈FN₅O₅
SMILES

COC(C=C(C(C(C)=C1C)=CN(C)C1=O)C=C2OC)=C2CN(CC3)CC4(CC4)N3CC5=C6C([C@H](N(CC6)C(/C(C#N)=C/C(C)(C)CF)=O)C(C)C)=CC(OC)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Martin O'Rourke, et al. Amx-883, a potent and selective degrader of BRD9 drives differentiation in acute myeloid leukaemia and shows synergistic efficacy in combination with venetoclax In Vivo and prevents the emergence of resistance to venetoclax in vitro. Blood (2025) 146 (Supplement 1): 1489.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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