Anti-Mouse IL-9 Antibody (9C1)
Based on 1 Customer Validation
Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
Mouse IgG2a kappa
Mouse
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NF-κB |
IL-9 |
Anti-Mouse IL-9 Antibody (9C1) (100 μg, i.p., once daily, for 5 days) effectively blocks Th9 cell-mediated allergic inflammatory response in C57BL/6 mice with sllergic reaction model[2].
Anti-Mouse IL-9 Antibody (9C1) (100 μg, i.p., once every 2 days, until the end of the experiment) significantly reduces the anti-tumor effect of Th9 cells in BALB/c mice bearing K7M2 or 4T1 tumors[3].
Anti-Mouse IL-9 Antibody (9C1) (0.5 mg, i.p., once daily, from day -1 to day 8) can improve parasitic anemia in male Swiss Albino mice with a Plasmodium berghei ANKA infected model[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2000 Echinococcus granulosus injected female BALB/c mice (8-10 weeks, 20 g)[1]
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Dosage:100 μg
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Administration:Intraperitoneal injection (i.p.), once every 3 days, for 12 weeks
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Result:Significantly reduced the mRNA levels of TLR2, NF-κB and IL-9.
Reduced inflammatory cell infiltration and fibrosis.
Exacerbated parasite proliferation and liver damage.
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Animal Model:Ovalbumin (OVA) (HY-P0286) (100 μg) and TSLP (HY-P70818) (200 ng) induced C57BL/6 mice[2]
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Dosage:100 μg
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Administration:Intraperitoneal injection (i.p.), once daily, for 5 days
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Result:Significantly reduced pulmonary eosinophil infiltration and inflammatory response.
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Animal Model:1×105 K7M2 or 4T1 cells injected BALB/c mice[3]
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Dosage:100 μg
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Administration:Intraperitoneal injection (i.p.), once every 2 days, until the end of the experiment
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Result:Significantly reduced the inhibitory effect of Th9 cells on tumor lung metastasis.
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Animal Model:1×106 infected red blood cells injected male Swiss Albino mice (6-8 weeks, 25 g)[4]
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Dosage:0.5 mg
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Administration:Intraperitoneal injection (i.p.), once daily, from day -1 to day 8
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Result:Significantly increased mouse survival rate to 66.67 %.
Reduced parasitic infections and neurological symptom scores.
Reduced Th17 cell frequency and improved Th17/Treg ratio imbalance.
Downregulated the expression of pro-inflammatory cytokines such as IL-6 and IL-1β.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo IL-9 neutralization
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-9 Antibody (9C1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Zhou T, et al. Association of IL-9 Cytokines with Hepatic Injury in Echinococcus granulosus Infection. Biomolecules. 2024 Aug 14;14(8):1007. [Content Brief]
[2]. Canaria DA, et al. IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6. Front Immunol. 2022 Nov 1;13:1032618. [Content Brief]
[3]. Chen T, et al. Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases. J Immunother Cancer. 2024 Dec 4;12(12):e009629. [Content Brief]
[4]. Ghosh S, et al. CD4+IL9+ (Th9) cells as the major source of IL-9, potentially modulate Th17/Treg mediated host immune response during experimental cerebral malaria. Mol Immunol. 2022 Dec;152:240-254. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-9 Antibody (9C1) Related Classifications
HY-P990208 Related Classifications
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