1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    SARS-CoV
  3. Aplidine

Aplidine (Synonyms: Plitidepsin)

Cat. No.: HY-16050
Handling Instructions

Aplidine (Plitidepsin) is a potent anti-cancer agent by targeting eEF1A2 ( KD=80 nM). Aplidine possesses antiviral activity and is against SARS-CoV-2 with an IC90 of 0.88 nM. Aplidine is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Aplidine Chemical Structure

Aplidine Chemical Structure

CAS No. : 137219-37-5

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Description

Aplidine (Plitidepsin) is a potent anti-cancer agent by targeting eEF1A2 ( KD=80 nM)[1]. Aplidine possesses antiviral activity and is against SARS-CoV-2 with an IC90 of 0.88 nM. Aplidine is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research[1][2].

In Vitro

Aplidine (20 nM; 1 h) induces a dose-dependent decrease in VEGF secretion in MOLT-4 cells[1].
Aplidine (20 nM; 1 h) does not result in significant inhibition of VEGF-R1 mRNA in normal endothelial cells, which do express VEGFR-1 but do not secrete VEGF[1].
Aplidine inhibits SARS-CoV-2 with an IC90 of 1.76 nM. In hACE2-293T cells, Aplidine exhibits anti–SARS-CoV-2 activity with an IC90 of 0.88 nM. In an established model of human pneumocyte-like cells, Aplidine inhibits SARS-CoV-2 replication with an IC90 of 3.14 nM and a selectivity index of 40.4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Plitidepsin (intraperitoneal injection; 0.3 mg/kg or 1 mg/kg; 2 hours before infection with SARS-CoV-2) significantly reduces SARS-CoV-2 infection in BALB/c mice expressing human ACE2. 0.3 mg/kg plitidepsin group results in a reduction of nearly 2 log units in SARS-CoV-2 viral titers in the lungs, and the 1 mg/kg group leads to a reduction of 1.5 log units relative to the vehicle control group[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 0.3 mg/kg; 1 mg/kg
Administration: 1 day QD at 1 mg/kg; 3days QD at 0.3 mg/kg
Result: Showed in vivo antiviral efficacy in mouse models of SARS-CoV-2 infection.
Molecular Weight

1110.34

Formula

C₅₇H₈₇N₇O₁₅

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Aplidine
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HY-16050
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