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Art. -Nr.: HY-16261A

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MC-DOXHZN

(Synonyms: (E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone)

5 Cited Publications

Kundenbewertung

Based on 5 publication(s) in Google Scholar

MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN can be used to synthesize ADC.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 151038-96-9
Formel: C₃₇H₄₂N₄O₁₃
Molecular Weight:750.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

MC-DOXHZN Chemical Structure

CAS. Nr.: 151038-96-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Daunorubicins/Doxorubicins

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

In Vitro

MC-DOXHZN conjugates to DTT-thiolated monoclonal antibodies (chimeric BR96, BR64, L6, human IgG) to form stable thioether-linked immunoconjugates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 151038-96-9
Molecular Weight 750.75
Formel C₃₇H₄₂N₄O₁₃
SMILES

[H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1
Synonyms

(E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Int J Pharm

Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer. [Abstract]

2016 Oct 15;512(1):1-13. PMID: 27521706
Mol Pharm

Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin. [Abstract]

2017 Nov 6;14(11):3739-3749. PMID: 28950700
Mol Pharm

Acid-Sensitive Peptide-Conjugated Doxorubicin Mediates the Lysosomal Pathway of Apoptosis and Reverses Drug Resistance in Breast Cancer. [Abstract]

2015 Jul 6;12(7):2217-28. PMID: 26035464
Bioconjug Chem

Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels. [Abstract]

2017 Oct 18;28(10):2530-2537. PMID: 28949511
China Biotechnology

2017, 37(4): 68-75.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Willner D, et al. (6-Maleimidocaproyl)hydrazone of doxorubicin--a new derivative for the preparation of immunoconjugates of doxorubicin. Bioconjug Chem. 1993;4(6):521-527. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MC-DOXHZN

5 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
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MC-DOXHZN

Publications Citing Use of MedChemExpress (MCE) MC-DOXHZN

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Alle Topoisomerase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (5)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MC-DOXHZN Related Classifications

HY-16261A Related Classifications