AMX-883
AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3102636-19-8
- Formel: C45H58FN5O5
- Molecular Weight:767.97
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
BRD9 |
In Vitro
Combination of AMX-883 with Venetoclax (HY-15531) resulted in synergistic efficacy in MV4-11 and MOLM-13 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3102636-19-8
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Molecular Weight 767.97
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Formel C45H58FN5O5
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SMILES
COC(C=C(C(C(C)=C1C)=CN(C)C1=O)C=C2OC)=C2CN(CC3)CC4(CC4)N3CC5=C6C([C@H](N(CC6)C(/C(C#N)=C/C(C)(C)CF)=O)C(C)C)=CC(OC)=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AMX-883 Related Classifications
HY-182766 Related Classifications
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