CDK12-IN-9
CDK12-IN-9 is a potent and selective CDK12 inhibitor with an IC50 of 2.2 nM. CDK12-IN-9 inhibits pSER2 (a downstream marker of CDK12/13 activity). CDK12-IN-9 can be used for the research of cancer.
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- CAS. Nr.: 3024723-74-5
- Formel: C23H20F2N10
- Molecular Weight:474.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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CDK12 2.2 nM (IC50) |
CDK13 13 nM (IC50) |
CDK9 466 nM (IC50) |
CDK2 551 nM (IC50) |
CDK7 1491 nM (IC50) |
CDK12-IN-9 (Compound 17) potently inhibits purified CDK12 kinase with an IC50 of 2.2 ± 0.74 nM[1].
CDK12-IN-9 inhibits purified CDK13, CD9, CD7 and CD2 kinase with IC50 values of 13, 466, 1491 and 551 nM[1].
CDK12-IN-9 inhibits cellular pSER2 (a downstream marker of CDK12/13 activity) with an IC50 of 17 ± 4.1 nM[1].
CDK12-IN-9 inhibits pSER2 activity in whole blood with an IC50 of 209 ± 106 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3024723-74-5
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Molecular Weight 474.47
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Formel C23H20F2N10
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SMILES
N#CC1=CC2=C(N(C=N2)[C@H]3CCC[C@H](C3)NC4=NC=C(C(C5=CN(N=C5)CC(F)F)=N4)C#N)N=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK12-IN-9 Related Classifications
HY-181645 Related Classifications
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