Art. -Nr.: HY-162088

DW71177

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DW71177 is a novel [1,2,4]triazolo[4,3-a] quinoxaline-based potent and BD1-Selective BET inhibitor, and can be used for study of acute myeloid leukemia.

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Reinheit: 97.70%
CAS. Nr.: 2241311-72-6
Formel: C₂₀H₂₈N₆O₂
Molecular Weight:384.48

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DW71177 Chemical Structure

CAS. Nr.: 2241311-72-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

DW71177 is a novel [1,2,4]triazolo[4,3-a] quinoxaline-based potent and BD1-Selective BET inhibitor, and can be used for study of acute myeloid leukemia^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
BJAB	GI₅₀	0.089 μM Compound: 9; DW-71177	Antiproliferative activity against human BJAB cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human BJAB cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
Daudi	GI₅₀	2.4 μM Compound: 9; DW-71177	Antiproliferative activity against human Daudi cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human Daudi cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
K562	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
KU-19-19	GI₅₀	9.1 μM Compound: 9; DW-71177	Antiproliferative activity against human KU-19-19 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human KU-19-19 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
LS-1034	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human LS1034 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human LS1034 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
MOLT-4	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
MV4-11	GI₅₀	0.05 μM Compound: 9; DW-71177	Cytotoxicity against human MV4-11 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Cytotoxicity against human MV4-11 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
NCI-H1666	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human NCI-H1666 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human NCI-H1666 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
NCI-H1975	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
Pfeiffer	GI₅₀	0.48 μM Compound: 9; DW-71177	Antiproliferative activity against human Pfeiffer cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human Pfeiffer cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
Raji	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human Raji cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human Raji cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
SUD4	GI₅₀	3.3 μM Compound: 9; DW-71177	Antiproliferative activity against human SU-DHL-4 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human SU-DHL-4 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
T-24	GI₅₀	5 μM Compound: 9; DW-71177	Antiproliferative activity against human T24 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human T24 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
THP-1	GI₅₀	0.05 μM Compound: 9; DW-71177	Antiproliferative activity against human THP-1 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human THP-1 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]
U2932	GI₅₀	>10 μM Compound: 9; DW-71177	Antiproliferative activity against human U2932 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay Antiproliferative activity against human U2932 cells assessed as growth inhibition incubated for 72 hrs by WST-1 assay	[PMID: 38134745]

Chemical Information

CAS. Nr. 2241311-72-6
Appearance Solid
Molecular Weight 384.48
Formel C₂₀H₂₈N₆O₂
Color White to off-white
SMILES

CC1=NN=C2C(NCCCCNC(CC(C)C)=O)=NC3=CC(OC)=CC=C3N21
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (130.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6009 mL

13.0046 mL

26.0092 mL

5 mM

0.5202 mL

2.6009 mL

5.2018 mL

10 mM

0.2601 mL

1.3005 mL

2.6009 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.50 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.50 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (6.50 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ali I, et al. DW71177: A novel [1,2,4]triazolo[4,3-a]quinoxaline-based potent and BD1-Selective BET inhibitor for the treatment of acute myeloid leukemia. Eur J Med Chem. Published online December 16, 2023. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6009 mL	13.0046 mL	26.0092 mL	65.0229 mL
	5 mM	0.5202 mL	2.6009 mL	5.2018 mL	13.0046 mL
	10 mM	0.2601 mL	1.3005 mL	2.6009 mL	6.5023 mL
	15 mM	0.1734 mL	0.8670 mL	1.7339 mL	4.3349 mL
	20 mM	0.1300 mL	0.6502 mL	1.3005 mL	3.2511 mL
	25 mM	0.1040 mL	0.5202 mL	1.0404 mL	2.6009 mL
	30 mM	0.0867 mL	0.4335 mL	0.8670 mL	2.1674 mL
	40 mM	0.0650 mL	0.3251 mL	0.6502 mL	1.6256 mL
	50 mM	0.0520 mL	0.2601 mL	0.5202 mL	1.3005 mL
	60 mM	0.0433 mL	0.2167 mL	0.4335 mL	1.0837 mL
	80 mM	0.0325 mL	0.1626 mL	0.3251 mL	0.8128 mL
	100 mM	0.0260 mL	0.1300 mL	0.2601 mL	0.6502 mL

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DW71177

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Histone Modification Research Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DW71177

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Histone Modification Research Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DW71177 Related Classifications

HY-162088 Related Classifications