E6 Berbamine
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia.
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- CAS. Nr.: 114784-59-7
- Formel: C44H43N3O9
- Molecular Weight:757.83
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
2.13 μM
Compound: 3n
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Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
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[PMID: 19285759] |
E6 Berbamine (2 min) acts as a competitive calmodulin (CaM) antagonist, potently inhibiting CaM-activated myosin light chain kinase (MLCK) activity in chicken gastric tissues, with a Ki of 0.95 μM and an IC50 of 8 μM[1].
E6 Berbamine binds directly to dansyl-labeled porcine brain CaM bound to Ca2+, with a Ki of approximately 1 μM[1].
E6 Berbamine inhibits the activity of calmodulin-dependent phosphodiesterase with an IC50 of 0.53 μM[1].
E6 Berbamine (Compound 3n) inhibits the activity of K562 cells with an IC50 value of 2.13 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 114784-59-7
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Molecular Weight 757.83
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Formel C44H43N3O9
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SMILES
COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]
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Synonyms
Berbamine p-nitrobenzoate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Hu ZY, et al. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem Pharmacol. 1992;44(8):1543-1547. [Content Brief]
[2]. Xie J, et al. Berbamine derivatives: a novel class of compounds for anti-leukemia activity. Eur J Med Chem. 2009;44(8):3293-3298. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
E6 Berbamine Related Classifications
HY-120997 Related Classifications
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- E6 Berbamine
- 114784-59-7
- Berbamine p-nitrobenzoate
- Calmodulin
- Myosin
- Phosphodiesterase (PDE)
- chicken MLCK
- CaM-dependent PDE
- porcine CaM
- cardiovascular abnormalities
- trypsinized MLCK fragments
- chicken gizzards
- imatinib-resistant chronic myelogenous leukemia
- porcine brain CaM
- calmodulin antagonist
- Inhibitor
- inhibitor
- inhibit