MS31
Based on 3 publication(s) in Google Scholar
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells.
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- CAS. Nr.: 2366264-12-0
- Formel: C20H27N3O2
- Molecular Weight:341.45
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) MS31
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Biologische Aktivität
IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]
Kd: 91 nM (SPIN1)[1]
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Cell Line
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Type | Value | Description | References |
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| U2OS | IC50 |
3.2 μM
Compound: 3; MS31
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Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
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[PMID: 31260300] |
MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2366264-12-0
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Molecular Weight 341.45
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Formel C20H27N3O2
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SMILES
NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks. [Abstract]2025 Jun;27(6):992-1005. PMID: 40447771 -
Adv Sci (Weinh)
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins. [Abstract]2025 Nov 29:e17751. PMID: 41316889 -
Nat Struct Mol Biol
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1. [Abstract]2025 Apr 17. PMID: 40247146
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MS31 Related Classifications
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