RS 39604
Based on 1 publication(s) in Google Scholar
RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 167710-87-4
- Formel: C26H37Cl2N3O6S
- Molecular Weight:590.56
-
Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) RS 39604
MoreAlle 5-HT Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
5-HT1A Receptor |
5-HT2C Receptor |
5-HT4 Receptor 9.1 (pKi) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>13.05 μM
Compound: GNF-Pf-5475
|
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
|
[PMID: 18579783] |
Chemical Information
-
CAS. Nr. 167710-87-4
-
Appearance Solid
-
Molecular Weight 590.56
-
Formel C26H37Cl2N3O6S
-
Color White to off-white
-
SMILES
CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OCC3=CC(OC)=CC(OC)=C3)=O)CC1)=O.Cl
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Neuron
2025 Apr 10:S0896-6273(25)00220-X. PMID: 40233747
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (84.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6933 mL | 8.4665 mL | 16.9331 mL | 42.3327 mL |
| 5 mM | 0.3387 mL | 1.6933 mL | 3.3866 mL | 8.4665 mL | |
| 10 mM | 0.1693 mL | 0.8467 mL | 1.6933 mL | 4.2333 mL | |
| 15 mM | 0.1129 mL | 0.5644 mL | 1.1289 mL | 2.8222 mL | |
| 20 mM | 0.0847 mL | 0.4233 mL | 0.8467 mL | 2.1166 mL | |
| 25 mM | 0.0677 mL | 0.3387 mL | 0.6773 mL | 1.6933 mL | |
| 30 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4111 mL | |
| 40 mM | 0.0423 mL | 0.2117 mL | 0.4233 mL | 1.0583 mL | |
| 50 mM | 0.0339 mL | 0.1693 mL | 0.3387 mL | 0.8467 mL | |
| 60 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL | |
| 80 mM | 0.0212 mL | 0.1058 mL | 0.2117 mL | 0.5292 mL |
RS 39604 Related Classifications
HY-101343 Related Classifications
Powered by Bioz