Teixobactin
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III.
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- CAS. Nr.: 1613225-53-8
- Formel: C58H95N15O15
- Molecular Weight:1242.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Teixobactin (0-128 µg/mL) shows antibacterial activity with a MIC value of 0.25 µg/mL for MRSA ATCC 33591[2].
Teixobactin (0-24 h) shows antibacterial activity with MIC values of 5, 20 ng/mL for Clostridium difficile, Bacillus anthracis, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice (MRSA ATCC33591)[3]
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Dosage:1, 2.5, 5, 10, 20 mg/kg
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Administration:i.v.; once; one hour post-infection
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Result:Showed good antibacterial activity and all treated animals survived.
Chemical Information
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CAS. Nr. 1613225-53-8
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Molecular Weight 1242.47
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Formel C58H95N15O15
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [Content Brief]
[2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [Content Brief]
[3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Teixobactin Related Classifications
HY-P0230 Related Classifications
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