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Art. -Nr.: HY-105028S

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Tenidap-d₃

Name: Tenidap-d3
Brand: MedChemExpress
SKU: HY-105028S
Availability: PreOrder

(Synonyms: CP-66248-d₃)

Tenidap-d₃ (CP-66248-d₃) is the deuterated-labeled Tenidap (CP-66248) (HY-105028). Tenidap (CP-66248) is an orally active cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor. Tenidap exerts anti-inflammatory and chondroprotective effects by downregulating IL-1 receptor expression, reducing the release of pro-inflammatory cytokines, and inhibiting metalloproteinase and acute-phase protein production, while also inhibiting SLC26A3-mediated chloride transport and the pH and membrane potential changes associated with sperm capacitation. Tenidap attenuates carrageenan-induced paw edema and acetic acid-induced writhing, and induces gastric ulcers in a dose-dependent manner, and can be used for research on rheumatoid arthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 142741-60-4
Formel: C₁₄H₆D₃ClN₂O₃S
Molecular Weight:323.77

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Tenidap-d₃ Chemical Structure

CAS. Nr.: 142741-60-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[5]^[2]

COX-1

2.56 μM (IC₅₀)

COX-2

8.4 μM (IC₅₀)

5-LOX

36.70 μM (IC₅₀)

IL-1

Alle COX Isoform-spezifische Produkte anzeigen :

Alle Lipoxygenase Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 142741-60-4
Unlabeled CAS 120210-48-2
Molecular Weight 323.77
Formel C₁₄H₆D₃ClN₂O₃S
SMILES

O/C(C1=C([2H])C([2H])=C([2H])S1)=C2C3=C(C=CC(Cl)=C3)N(C(N)=O)C/2=O
Synonyms

CP-66248-d₃
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Blackburn, et al. (1995), Tenidap in rheumatoid arthritis a 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis & Rheumatism, 38: 1447-1456.

[2]. Breedveld F, et al. Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis. Scandinavian journal of rheumatology. Supplement. 1994;100:31-44. [Content Brief]

[3]. Julio C, et al. Participation of the Cl−/HCO3− Exchangers SLC26A3 and SLC26A6, the Cl− Channel CFTR, and the Regulatory Factor SLC9A3R1 in Mouse Sperm Capacitation, Biology of Reproduction, Volume 86, Issue 1, 1 January 2012, 14, 1-14.

[4]. Yi Liu, et al. Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3, European Journal of Pharmacology, Volume 435, Issues 2-3, 2002, Pages 153-160, ISSN 0014-2999.

[5]. Lai Y, et al. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorganic & medicinal chemistry letters. 2010 Dec 15;20(24):7349-53.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

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Tenidap-d₃

Alle COX Isoform-spezifische Produkte anzeigen

Alle Lipoxygenase Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen