Ticarcillin
Based on 7 publication(s) in Google Scholar
Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research.
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- CAS. Nr.: 34787-01-4
- Formel: C15H16N2O6S2
- Molecular Weight:384.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ticarcillin
More- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0160322. [Abstract]
- J Antimicrob Chemother. 2025 Nov 5:dkaf408. [Abstract]
- Microbiol Spectr. 2023 Jun 15;11(3):e0069223. [Abstract]
- Microbiol Spectr. 2023 Feb 14;11(1):e0303822. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
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Biologische Aktivität
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β-lactam |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
233 μM
Compound: Ticarcillin
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Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
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[PMID: 23344796] |
Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ps. aeruginosa
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Concentration:10 mg/L
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Incubation Time:18 hours
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Result:Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L.
Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss type male mice injected with Ps. aeruginosa[2]
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Dosage:50, 100, 200 mg/kg
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Administration:Subcutaneous injection; 50, 100, 200 mg/kg; once
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Result:Increased effect significantly (0.001 < P < 0.0025) with increasing dose.
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Animal Model:Swiss type male mice injected with Ps. aeruginosa[2]
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Dosage:50, 100, 200 mg/kg
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Administration:Subcutaneous injection; 50, 100, 200 mg/kg; once
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Result:
Dose (mg/kg) AUCa (mg/kg) Kelb (h-1) T1/2 (min) Ticarcillin 50 8.76 (0.72) 1.57 (0.18) 26 100 26.14 (0.60) 1.53 (0.11) 27 200 54.56 (2.90) 1.47 (0.12) 28
Chemical Information
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CAS. Nr. 34787-01-4
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Molecular Weight 384.43
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Formel C15H16N2O6S2
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SMILES
OC([C@H](C1=CSC=C1)C(N[C@H]2[C@]3([H])N(C2=O)[C@H](C(C)(S3)C)C(O)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Antimicrob Agents Chemother
Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology. [Abstract]2023 Jun 15;67(6):e0160322. PMID: 37199612 -
J Antimicrob Chemother
Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction. [Abstract]2025 Nov 5:dkaf408. PMID: 41206063 -
Microbiol Spectr
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae. [Abstract]2023 Jun 15;11(3):e0069223. PMID: 37093051 -
Microbiol Spectr
PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability. [Abstract]2023 Feb 14;11(1):e0303822. PMID: 36475840 -
Reinheit & Dokumentation
Verweise
[1]. Cecile Formosa, et al. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine. 2012 Jan;8(1):12-6. [Content Brief]
[2]. G B van der Voet, et al. Comparison of the antibacterial activity of azlocillin and ticarcillin in vitro and in irradiated neutropenic mice. J Antimicrob Chemother. 1985 Nov;16(5):605-13. [Content Brief]
[3]. Oriel Spierer, et al. Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates. Br J Ophthalmol. 2018 May;102(5):708-712. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ticarcillin Related Classifications
HY-139805 Related Classifications
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