UK-2A
UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity.
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- CAS. Nr.: 167173-85-5
- Formel: C26H30N2O9
- Molecular Weight:514.52
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| RBL-2H3 | IC50 |
1377 nM
Compound: 1; UK-2A
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Anti-inflammatory activity in DNP-IgE-stimulated rat RBL2H3 cells assessed as reduction of IL4 secretion pretreated for 10 mins followed by DNP-HSA stimulation measured after 1 hr by ELISA
Anti-inflammatory activity in DNP-IgE-stimulated rat RBL2H3 cells assessed as reduction of IL4 secretion pretreated for 10 mins followed by DNP-HSA stimulation measured after 1 hr by ELISA
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[PMID: 30417645] |
UK-2A (0-100 µg/mL; 24, 48, 120 h) shows antifungal activity against R. mucilaginosa IFO 0001 with MICs of 1.56, >100, >100 µg/mL at 24, 48, 120 h, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 167173-85-5
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Molecular Weight 514.52
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Formel C26H30N2O9
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SMILES
CC(C)C(O[C@H]([C@H]1CC2=CC=CC=C2)[C@H](C)OC([C@@H](NC(C3=NC=CC(OC)=C3O)=O)COC1=O)=O)=O
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Synonyms
Antibiotic UK 2A
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Structure Classification
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Initial Source
Streptomyces sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Ueki M, et al. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties. J Antibiot (Tokyo). 1996 Jul;49(7):639-43. [Content Brief]
[2]. Tani K, et al. UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J Antibiot (Tokyo). 2002 Mar;55(3):315-21. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UK-2A Related Classifications
HY-19965 Related Classifications
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