WAY 629
WAY 629 is a potent and selective 5-HT2C agonist with EC50s of 426, 260000 nM for 5-HT2C and 5-HT2A, respectively. WAY 629 decreases feeding behavior.
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- CAS. Nr.: 57756-45-3
- Formel: C15H18N2
- Molecular Weight:226.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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5-HT2A Receptor |
5-HT2C Receptor |
5-HT2C Receptor 426 nM (EC50) |
5-HT2A Receptor 260000 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | EC50 |
261 nM
Compound: 6, WAY-629
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Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
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[PMID: 19284718] |
WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT mice[2]
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Dosage:21 mg/kg
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Administration:I.p.
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Result:Decreased the expression of NPY mRNA.
Chemical Information
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CAS. Nr. 57756-45-3
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Molecular Weight 226.32
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Formel C15H18N2
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SMILES
N1(CCNC2)C3=C(C4=CC=CC2=C41)CCCC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7. [Content Brief]
[2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
WAY 629 Related Classifications
HY-103144A Related Classifications
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