Zilovertamab
Based on 2 publication(s) in Google Scholar
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.21%
- CAS. Nr.: 2485779-13-1
- Molecular Weight:145.12 kDa
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Zilovertamab
More
Biologische Aktivität
Beschreibung
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
|
Wnt5A |
In Vitro
Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:CaOV3, CaOV3CisR, PEO1, and PEO4 cells
-
Concentration:25 and 50 µg/mL
-
Incubation Time:72 hours
-
Result:Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.
-
Cell Line:CaOV3, CaOV3CisR, PEO1, and PEO4 cells
-
Concentration:50 µg/mL
-
Incubation Time:72 hours
-
Result:Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Q01973
Target
ROR1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Human IgG1 kappa
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC50 for this effect is 3.078 ng/mL.
Chemical Information
-
CAS. Nr. 2485779-13-1
-
Appearance Liquid
-
Molecular Weight 145.12 kDa
-
Color Colorless to light yellow
-
SMILES
[Zilovertamab]
-
Synonyms
UC-961; Cirmtuzumab
-
Versand
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Mol Ther
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy. [Abstract]2025 Dec 2:S1525-0016(25)00959-1. PMID: 41338184 -
Reinheit & Dokumentation
-
Data Sheet (260 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Zilovertamab Related Classifications
HY-P99201 Related Classifications
Powered by Bioz