Zilovertamab
Based on 2 publication(s) in Google Scholar
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.21%
- CAS. Nr.: 2485779-13-1
- Molecular Weight:145.12 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Zilovertamab
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Biologische Aktivität
Human IgG1 kappa
Human
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Wnt5A |
Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CaOV3, CaOV3CisR, PEO1, and PEO4 cells
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Concentration:25 and 50 µg/mL
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Incubation Time:72 hours
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Result:Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.
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Cell Line:CaOV3, CaOV3CisR, PEO1, and PEO4 cells
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Concentration:50 µg/mL
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Incubation Time:72 hours
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Result:Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Q01973
ROR1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC50 for this effect is 3.078 ng/mL.
Chemical Information
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CAS. Nr. 2485779-13-1
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Appearance Liquid
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Molecular Weight 145.12 kDa
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Color Colorless to light yellow
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SMILES
[Zilovertamab]
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Synonyms
UC-961; Cirmtuzumab
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Mol Ther
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy. [Abstract]2025 Dec 2:S1525-0016(25)00959-1. PMID: 41338184 -
Reinheit & Dokumentation
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Data Sheet (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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