BRD4-IN-5
BRD4-IN-5 (example 51) is a BRD4 inhibitor. The Ki values of the two BRD4 domains BDI_K57-E168 and BDII_E352-M457 are 9.7 nM and 16.1 nM, respectively. BRD4-IN-5 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1445993-41-8
- Formula: C25H21F2N3O4
- Molecular Weight:465.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BDI_K57-E168 9.7 nM (Ki) |
BDII_E352-M457 16.1 nM (Ki) |
BRD4-IN-5 (example 51) has half-lives of 6 minutes in human liver microsomes, 63 minutes in mouse liver microsomes, and more than 120 minutes in rat liver microsomes, respectively[1]. BRD4-IN-5 (3 days) inhibits cell proliferation against the breast cancer cell line MX-1, with an EC50 of 0.101 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1445993-41-8
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Molecular Weight 465.45
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Formula C25H21F2N3O4
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SMILES
CN1C=C(C2=C(OC3=C(F)C=C(F)C=C3)C=CC(C(NC4CCOC4)=O)=C2)C5=C(NC=C5)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD4-IN-5 Related Classifications
HY-160662 Related Classifications
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