LC-PDA-01
Based on 1 Customer Validation
LC-PDA-01 is a selective peroxiredoxin 1 (PRDX1) activator with an EC50 of 111.8 nM and a human KD of 123.2 nM. LC-PDA-01 inhibits the expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α. LC-PDA-01 can be used in antioxidant/anti-inflammatory research.
For research use only. We do not sell to patients.
- Purity : 99.19%
- Formula: C18H15Cl2N5O4
- Molecular Weight:436.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
LC-PDA-01 (100 μM; 3 h) significantly stabilizes endogenous PRDX1 protein in HEK-293T human embryonic kidney cells, as measured by cellular thermal shift assay[1].
LC-PDA-01 (20 μM) significantly suppresses LPS (HY-D1056)-induced expression of IL-1β, IL-6, and TNF-α mRNA in RAW 264.7 mouse macrophages[1].
LC-PDA-01 (Incubated to measure half-life of 381.6 min) shows excellent metabolic stability in mouse liver microsomes, with a half-life of 381.6 min and a hepatic extraction ratio of 13.7%[1].
LC-PDA-01 has low apparent permeability (Papp A→B = 0.06 × 10-6 cm/s) across Caco-2 monolayers, with a high efflux ratio of 5.23, suggesting potential P-gp-mediated active efflux[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 436.25
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Formula C18H15Cl2N5O4
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SMILES
NC1=CC=C(C=C1)C[C@H](C(O)=O)NC(C2=CN(N=N2)C3=CC(Cl)=CC(Cl)=C3O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (229.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2923 mL | 11.4613 mL | 22.9226 mL | 57.3066 mL |
| 5 mM | 0.4585 mL | 2.2923 mL | 4.5845 mL | 11.4613 mL | |
| 10 mM | 0.2292 mL | 1.1461 mL | 2.2923 mL | 5.7307 mL | |
| 15 mM | 0.1528 mL | 0.7641 mL | 1.5282 mL | 3.8204 mL | |
| 20 mM | 0.1146 mL | 0.5731 mL | 1.1461 mL | 2.8653 mL | |
| 25 mM | 0.0917 mL | 0.4585 mL | 0.9169 mL | 2.2923 mL | |
| 30 mM | 0.0764 mL | 0.3820 mL | 0.7641 mL | 1.9102 mL | |
| 40 mM | 0.0573 mL | 0.2865 mL | 0.5731 mL | 1.4327 mL | |
| 50 mM | 0.0458 mL | 0.2292 mL | 0.4585 mL | 1.1461 mL | |
| 60 mM | 0.0382 mL | 0.1910 mL | 0.3820 mL | 0.9551 mL | |
| 80 mM | 0.0287 mL | 0.1433 mL | 0.2865 mL | 0.7163 mL | |
| 100 mM | 0.0229 mL | 0.1146 mL | 0.2292 mL | 0.5731 mL |
LC-PDA-01 Related Classifications
HY-182308 Related Classifications
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