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Cat. No.: HY-160865

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PRMT5-IN-35

Name: PRMT5-IN-35
Brand: MedChemExpress
SKU: HY-160865
Price: 65.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

PRMT5-IN-35 (Compound 87) is a potent, selective and orally active PRMT5 inhibitor with an IC₅₀ value of 1 nM. PRMT5-IN-35 can be used in cancer research.

For research use only. We do not sell to patients.

Purity : 99.30%
CAS No.: 1989620-03-2
Formula: C₁₇H₁₇ClN₄O₄
Molecular Weight:376.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PRMT5-IN-35 Chemical Structure

CAS No.: 1989620-03-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PRMT5-IN-35 (Compound 87) is a potent, selective and orally active PRMT5 inhibitor with an IC₅₀ value of 1 nM. PRMT5-IN-35 can be used in cancer research^[1].

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	10.8 nM Compound: 46	Antiproliferation activity against human A-375 cells assessed as cell growth inhibition Antiproliferation activity against human A-375 cells assessed as cell growth inhibition	[PMID: 36274274]
A-375	IC₅₀	11 nM Compound: 2	Antiproliferative activity against human A375 cells measured after 7 days by cell titer glo-based luminescence assay Antiproliferative activity against human A375 cells measured after 7 days by cell titer glo-based luminescence assay	[PMID: 30956011]
A549	IC₅₀	5 nM Compound: 2	Antiproliferative activity against human A549 cells incubated for 7 days with compound replacement on day 4 by cell titer glo-based luminescence assay Antiproliferative activity against human A549 cells incubated for 7 days with compound replacement on day 4 by cell titer glo-based luminescence assay	[PMID: 30956011]
Sf21	IC₅₀	1 nM Compound: 2	Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells using H4(1-21) peptide SGRGKGGKGLGKGGAKRHRKV as substrate measured after 25 minutes in the presence of [3H]S Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells using H4(1-21) peptide SGRGKGGKGLGKGGAKRHRKV as substrate measured after 25 minutes in the presence of [3H]S	[PMID: 30956011]
Sf9	IC₅₀	4.3 nM Compound: 2	Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovirus infected Sf9 insect cells assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histon Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovirus infected Sf9 insect cells assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histon	[PMID: 30956011]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 1989620-03-2
Appearance Solid
Molecular Weight 376.79
Formula C₁₇H₁₇ClN₄O₄
Color White to off-white
SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3C=C2)O[C@@H]1[C@H](O)C4=CC=C(Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (331.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6540 mL

13.2700 mL

26.5400 mL

5 mM

0.5308 mL

2.6540 mL

5.3080 mL

10 mM

0.2654 mL

1.3270 mL

2.6540 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ferrarotto R, et al. PRT543, a protein arginine methyltransferase 5 inhibitor, in patients with advanced adenoid cystic carcinoma: An open-label, phase I dose-expansion study. Oral Oncol. 2024 Feb;149:106634. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6540 mL	13.2700 mL	26.5400 mL	66.3500 mL
	5 mM	0.5308 mL	2.6540 mL	5.3080 mL	13.2700 mL
	10 mM	0.2654 mL	1.3270 mL	2.6540 mL	6.6350 mL
	15 mM	0.1769 mL	0.8847 mL	1.7693 mL	4.4233 mL
	20 mM	0.1327 mL	0.6635 mL	1.3270 mL	3.3175 mL
	25 mM	0.1062 mL	0.5308 mL	1.0616 mL	2.6540 mL
	30 mM	0.0885 mL	0.4423 mL	0.8847 mL	2.2117 mL
	40 mM	0.0663 mL	0.3317 mL	0.6635 mL	1.6587 mL
	50 mM	0.0531 mL	0.2654 mL	0.5308 mL	1.3270 mL
	60 mM	0.0442 mL	0.2212 mL	0.4423 mL	1.1058 mL
	80 mM	0.0332 mL	0.1659 mL	0.3317 mL	0.8294 mL
	100 mM	0.0265 mL	0.1327 mL	0.2654 mL	0.6635 mL

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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PRMT5-IN-35

All Histone Methyltransferase Isoforms

Biological Activity

Description

Cellular Effect

Clinical Trial

Chemical Information

Solvent & Solubility

In Vitro:

In Vivo Dissolution Calculator

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PRMT5-IN-35 Related Classifications

HY-160865 Related Classifications

Bioz

Keywords

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