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Cat. No.: HY-108331R

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3-TYP (Standard)

3-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC₅₀of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 120241-79-4
Formule: C₇H₆N₄
Masse moléculaire:146.15

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-TYP (Standard) Chemical Structure

CAS No.: 120241-79-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Targets: Sirtuin (SIRT) 3, Methionine Adenosyltransferase (MAT) 2, Indoleamine 2,3-Dioxygenase (IDO)^[3]
IC50: ~38 μM (SIRT3)^[3]

Voir tous les produits spécifiques à Isoform Sirtuin :

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO) :

Chemical Information

CAS No. 120241-79-4
Masse moléculaire 146.15
Formule C₇H₆N₄
SMILES

C1(C2=CN=NN2)=CC=CN=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51. [Content Brief]

[2]. Zhai M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017 Sep;63(2). [Content Brief]

[3]. Galli U, et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem. 2012 Sep;55:58-66. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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3-TYP (Standard)

Voir tous les produits spécifiques à Isoform Sirtuin

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

3-TYP (Standard) Related Classifications

HY-108331R Related Classifications