Hypericaceae

3-Isomangostin hydrate (Compound 17) is an xanthone that can be isolated from Cratoxylum formosum ssp. pruniflorum and exhibits antibacterial activity.

Uralione E is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP). Uralione E exhibits a protective effect against corticosterone (HY-B1618)-induced damage in PC12 cells. In a free fatty acid (FFA)-induced L02 cell model, Uralione E dose-dependently reduces intracellular lipid accumulation, downregulates the expression of FASN and CD36, and upregulates the expression of ACOX1 and PPARα. Uralione E can be used in studies related to neuronal cell damage, lipid metabolism, and non-alcoholic steatohepatitis.

Uralione D is a neuroprotective agent found in Hypericum uralum and Hypericum kouytchense. Uralione D exhibits cytotoxic activity against gastric cancer cells and protects against Corticosterone (HY-B1618)-induced damage in neuron-like cells. Uralione D is useful for research on depression, multidrug-resistant liver cancer, and gastric cancer.

Hypatulin A is a terpenoid compound found in the leaves of Hypericum patulum. Hypatulin A exhibits antibacterial activity against Bacillus subtilis. Hypatulin A can be used in research related to bacterial infections.

Uralione I is a polycyclic polyprenylated acylphloroglucinol (PPAP) found in the whole plant of Hypericum uralum. Uralione I can be used for research on depression.

Uralodin A is a polycyclic polyprenylated acylphloroglucinol (PPAP). Uralodin A exerts cytotoxic activity through its inhibitory effects on tumor cells. Uralodin A can be used for cancer-related research.

Uralodin B is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP) and is the C (30)-epimer of Uralodin C. It is found in the aerial parts of Hypericum henryi subsp. uraloides. Uralodin B exhibits cytotoxic activity against SGC7901 and HL-60 tumor cells. It is useful for research related to PPAP natural products and tumor cytotoxicity.

Attenuatumione H is a polycyclic polyprenylated acylphloroglucinol compound found in the whole plant of Hypericum attenuatum, and it exhibits antitumor activity. Attenuatumione H exerts cytotoxic effects on liver cancer cells and breast cancer cells. Attenuatumione H shows no significant inhibitory effect on LPS-induced NO production in macrophages and displays no significant cytotoxic activity against osteosarcoma cells. Attenuatumione H can be used in cancer research.

Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research.

3,8-Dihydroxy-1,2-dimethoxyxanthone is a xanthone compound found in the leaves and stems of Hypericum geminiflorum.

5,7-Dihydroxy-2-isopropylchromone (Compound 9) is a chromone derivative. 5,7-Dihydroxy-2-isopropylchromone can be isolated from the leaves of Hypericum ascyron.

Dulcisxanthone B is an antioxidant agent with free radical scavenging against DPPH (IC₅₀ of 0.39 mM) and lipid peroxidation inhibition (IC₅₀ of 024 μM).

Petiolin G is a natural phenolic compound.