TG6-10-1
Based on 9 publication(s) in Google Scholar
TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.50%
- CAS No.: 1415716-58-3
- Formule: C23H23F3N2O4
- Masse moléculaire:448.43
-
Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-18966
PF-04418948EP2 Receptor Antagonist -
HY-50901
ONO-AE3-208EP4 Recepto Antagonist -
HY-16963
GW627368Prostaglandin Receptor Antagonist -
HY-108559
L-161982EP4 Receptor Antagonist -
HY-B0745
RamatrobanThromboxane A2 Receptor Antagonist -
HY-16635
SetipiprantCRTH2 Antagonist -
HY-16781
GrapiprantEP4 Receptor Antagonist -
HY-50175
LaropiprantDP Receptor Antagonist -
HY-16763
AsapiprantProstaglandin Receptor Antagonist -
HY-114141
BI-671800Prostaglandin Receptor Antagonist -
HY-13213
AM211 -
HY-16635R
Setipiprant (Standard)CRTH2 Antagonist
Publications Citing Use of MedChemExpress (MCE) TG6-10-1
More- Nat Immunol. 2023 May;24(5):767-779. [Abstract]
- Ann Rheum Dis. 2025 Oct 28:S0003-4967(25)04428-0. [Abstract]
- Nat Cell Biol. 2021 Jul;23(7):796-807. [Abstract]
- J Nanobiotechnology. 2025 Dec 12;23(1):765. [Abstract]
- Br J Pharmacol. 2019 Jun;176(11):1680-1699. [Abstract]
- Sci Rep. 2017 Aug 25;7(1):9459. [Abstract]
- Neuropharmacology. 2019 May 1:149:149-160. [Abstract]
- J Cell Physiol. 2018 Nov;233(11):8984-8995. [Abstract]
- Mod Rheumatol. 2020 May;30(3):509-516. [Abstract]
Customer Validation & Images
-
WB
Voir tous les produits spécifiques à Isoform 5-HT Receptor
More
Activité biologique
Description
IC50 & Target
EP2[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| C6 | CC50 |
81 μM
Compound: 5d, TG6-10-1
|
Cytotoxicity against rat C6 cells assessed as cell viability
Cytotoxicity against rat C6 cells assessed as cell viability
|
[PMID: 24773616] |
In Vitro
TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice (pilocarpine-induced SE)[1]
-
Dosage:5 mg/kg
-
Administration:Intraperitoneal injection; 4, 21, 30 hours
-
Result:A significant increase in survival and accelerating the recovery of lost weight in post-SE mice.
Chemical Information
-
CAS No. 1415716-58-3
-
Appearance Solid
-
Masse moléculaire 448.43
-
Formule C23H23F3N2O4
-
Color White to off-white
-
SMILES
O=C(NCCN1C(C(F)(F)F)=CC2=C1C=CC=C2)/C=C/C3=CC(OC)=C(OC)C(OC)=C3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
-
Journal Impact Factor
-
Most Recent
-
Nat Immunol
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis. [Abstract]2023 May;24(5):767-779. PMID: 37095375 -
Ann Rheum Dis
2025 Oct 28:S0003-4967(25)04428-0. PMID: 41162285 -
Nat Cell Biol
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis. [Abstract]2021 Jul;23(7):796-807. PMID: 34239062 -
J Nanobiotechnology
Targeting pre-metastatic niche with inhalable dendritic cell vesicles to prevent breast cancer lung metastasis. [Abstract]2025 Dec 12;23(1):765. PMID: 41388289 -
Br J Pharmacol
Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. [Abstract]2019 Jun;176(11):1680-1699. PMID: 30761522 -
Sci Rep
Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. [Abstract]2017 Aug 25;7(1):9459. PMID: 28842681 -
Neuropharmacology
Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury. [Abstract]2019 May 1:149:149-160. PMID: 30763657 -
J Cell Physiol
Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE2 -EP2 signaling in chickens. [Abstract]2018 Nov;233(11):8984-8995. PMID: 29923198
TG6-10-1 purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Nov;233(11):8984-8995. [Abstract]
Small white follicles (SWFs) are treated with TG6-10-1 or GW627368 and WB are used and gray analysis of PCNA, CDK2, and CCND1.
-
Mod Rheumatol
ER-stressed MSC displayed more effective immunomodulation in RA CD4+CXCR5+ICOS+ follicular helper-like T cells through higher PGE2 binding with EP2/EP4. [Abstract]2020 May;30(3):509-516. PMID: 31370727
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (223.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3 mg/mL (6.69 mM); Clear solution
This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
-
Fiche technique (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Jiang J, et al. Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-3596. [Content Brief]
[2]. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2300 mL | 11.1500 mL | 22.3000 mL | 55.7501 mL |
| 5 mM | 0.4460 mL | 2.2300 mL | 4.4600 mL | 11.1500 mL | |
| 10 mM | 0.2230 mL | 1.1150 mL | 2.2300 mL | 5.5750 mL | |
| 15 mM | 0.1487 mL | 0.7433 mL | 1.4867 mL | 3.7167 mL | |
| 20 mM | 0.1115 mL | 0.5575 mL | 1.1150 mL | 2.7875 mL | |
| 25 mM | 0.0892 mL | 0.4460 mL | 0.8920 mL | 2.2300 mL | |
| 30 mM | 0.0743 mL | 0.3717 mL | 0.7433 mL | 1.8583 mL | |
| 40 mM | 0.0558 mL | 0.2788 mL | 0.5575 mL | 1.3938 mL | |
| 50 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1150 mL | |
| 60 mM | 0.0372 mL | 0.1858 mL | 0.3717 mL | 0.9292 mL | |
| 80 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.6969 mL | |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.2230 mL | 0.5575 mL |
TG6-10-1 Related Classifications
HY-16978 Related Classifications
Powered by Bioz