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Cat. No.: HY-N7227

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Anonaine

Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor.

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Pureté: 95.0%
CAS No.: 1862-41-5
Formule: C₁₇H₁₅NO₂
Masse moléculaire:265.31

Stockage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Anonaine Chemical Structure

CAS No.: 1862-41-5

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	4.2 μg/mL Compound: 3	Cytotoxicity against human A431 cells after 3 days by SRB assay Cytotoxicity against human A431 cells after 3 days by SRB assay	[PMID: 8254346]
AGS	IC₅₀	8.6 μM Compound: 5	Cytotoxicity against human AGS cells by MTS colorimetric assay Cytotoxicity against human AGS cells by MTS colorimetric assay	[PMID: 11087586]
DLD-1	IC₅₀	28.9 μM Compound: 5	Cytotoxicity against human DLD1 cells by MTS colorimetric assay Cytotoxicity against human DLD1 cells by MTS colorimetric assay	[PMID: 11087586]
HeLa	IC₅₀	24.8 μg/mL Compound: Anonaine, III	Cytotoxicity against human HeLa cells after 24 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 hrs by MTT assay	[PMID: 18295494]
Hepatocyte	IC₅₀	70.3 μg/mL Compound: Anonaine, III	Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay	[PMID: 18295494]
HepG2	IC₅₀	20.8 μM Compound: 5	Cytotoxicity against human HepG2 cells by MTS colorimetric assay Cytotoxicity against human HepG2 cells by MTS colorimetric assay	[PMID: 11087586]
HepG2	IC₅₀	33.5 μg/mL Compound: Anonaine, III	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 18295494]
HT-1080	ED₅₀	2.4 μg/mL Compound: 3	Cytotoxicity against human HT1080 cells after 3 days by SRB assay Cytotoxicity against human HT1080 cells after 3 days by SRB assay	[PMID: 8254346]
KB	ED₅₀	2.6 μg/mL Compound: 3	Cytotoxicity against human KB cells after 3 days by SRB assay Cytotoxicity against human KB cells after 3 days by SRB assay	[PMID: 8254346]
KB-V1	ED₅₀	1.8 μg/mL Compound: 3	Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay	[PMID: 8254346]
LNCaP	ED₅₀	2.9 μg/mL Compound: 3	Cytotoxicity against human LNCAP cells after 3 days by SRB assay Cytotoxicity against human LNCAP cells after 3 days by SRB assay	[PMID: 8254346]
P388	ED₅₀	>5 μg/mL Compound: 3	Cytotoxicity against mouse P388 cells after 3 days by SRB assay Cytotoxicity against mouse P388 cells after 3 days by SRB assay	[PMID: 8254346]
SK-MEL-2	ED₅₀	15.8 μg/mL Compound: 3	Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay	[PMID: 8254346]
U-373MG ATCC	ED₅₀	1.5 μg/mL Compound: 3	Cytotoxicity against human U373 cells after 3 days by SRB assay Cytotoxicity against human U373 cells after 3 days by SRB assay	[PMID: 8254346]
ZR-75-1	ED₅₀	2.7 μg/mL Compound: 3	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	[PMID: 8254346]

Chemical Information

CAS No. 1862-41-5
Appearance Solid
Masse moléculaire 265.31
Formule C₁₇H₁₅NO₂
Color Light brown to brown
SMILES

[H][C@@]1(NCC2)CC3=CC=CC=C3C4=C1C2=CC5=C4OCO5
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bezerra WADS, et al. Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887). Exp Parasitol. 2022 Dec;243:108398. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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Anonaine

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