Antimycin A2
Based on 3 publication(s) in Google Scholar
Antimycin A2 is a selective inhibitor of the cytochrome b-c1 complex in the mitochondrial electron transport chain. Antimycin A2 disrupts mitochondrial membrane potential and produces reactive oxygen species (ROS) by inhibiting electron transfer between cytochrome b and c. Antimycin A2 has bactericidal and piscicidal activity, as well as tumor cell growth inhibitory effects, and can induce S-phase cell cycle arrest and apoptosis in HeLa cells. Antimycin A2 is suitable for research of cervical cancer and fisheries management. Antimycin A2 can be naturally isolated from the fermentation products of Streptomyces sp. strains.
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- Pureté: 99.0%
- CAS No.: 27220-57-1
- Formule: C27H38N2O9
- Masse moléculaire:534.60
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Antimycin A2
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Activité biologique
Antimycin A2 (0.1-1.0 μg/mL; overnight incubation at 30°C) inhibits the growth of Saccharomyces cerevisiae Y-30, exhibiting the same fungicidal activity as the Antimycin A complex and its other major components (A1, A3, A4). The activity, corresponding to the diameter of the inhibition zone, of 82% (relative to the complex at 100%), and the actual minimum inhibitory concentration (m1) was 0.048-0.051 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Saccharomyces cerevisiae Y-30
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Concentration:0.1-1.0 μg/mL
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Incubation Time:16 h
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Result:Displayed the same fungicidal activity as the Antimycin A complex and other major components (A1, A3, A4) with the minimum inhibitory concentration ranging from 0.048 to 0.051 μg/mL.
The apparent difference in inhibition zone sizes was caused by its diffusion coefficient in agar rather than inherent biological activity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Common goldfish (5 cm in length) teleocidal activity evaluation model[1]
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Dosage:25 ppb (acetone), 50 ppb (acetone), 75 ppb (acetone)
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Administration:
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Result:Antimycin A2 showed equivalent teleocidal activity to the Antimycin A complex and other major components (A1, A3, A4) in common goldfish.
No significant differences in the mean death time of goldfish were detected among Antimycin A2, the complex, and other fractions at the tested concentrations, confirming that its fish-toxic potential was consistent with other components of the Antimycin A complex.
Chemical Information
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CAS No. 27220-57-1
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Appearance Solid
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Masse moléculaire 534.60
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Formule C27H38N2O9
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Color White to off-white
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SMILES
CCCC(O[C@H]([C@H]1CCCCCC)[C@H](C)OC([C@@H](NC(C2=CC=CC(NC=O)=C2O)=O)[C@@H](C)OC1=O)=O)=O
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Structure Classification
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Initial Source
Streptomyces species
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Autophagy
ATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma. [Abstract]2025 Dec 26:1-18. PMID: 41358570 -
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J Biol Chem
Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells. [Abstract]2026 May 27:113207. PMID: 42208899
Pureté et documentation
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Fiche technique (272 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimycin A2 Related Classifications
HY-N12257 Related Classifications
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