Artemisic acid
Based on 1 Customer Validation
Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect.
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- Pureté: 99.62%
- CAS No.: 80286-58-4
- Formule: C15H22O2
- Masse moléculaire:234.33
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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IL-6 |
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Cell Line
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Type | Value | Description | References |
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| Ehrlich | IC50 |
>175 μM
Compound: 17
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Cytotoxicity against mouse EAC after 3 days by MTT assay
Cytotoxicity against mouse EAC after 3 days by MTT assay
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[PMID: 8350087] |
Artemisinic acid (0-400 μM; 0-15 days) inhibits adipogenesis in hAMSCs by reducing triglyceride accumulation and decreasing GPDH activity, and can downregulate C/EBP δ expression. The mechanism involves the inhibition of JNK[2].
Artemisinic acid (0-200 μM; 2 days) significantly reduces TNF-α-induced IL-6 secretion in undifferentiated hAMSCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hAMSCs treated TNF-α
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Concentration:0, 10, 50, 100 and 200 μM
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Incubation Time:2 days
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Result:Significantly reduced TNF-α-induced IL-6 secretion in undifferentiated hAMSCs, with no effect when treated alone.
Chemical Information
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CAS No. 80286-58-4
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Appearance Solid
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Masse moléculaire 234.33
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Formule C15H22O2
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Color White to off-white
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SMILES
O=C(O)C([C@@H]1CC[C@@H](C)[C@]2([H])CCC(C)=C[C@]12[H])=C
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Synonyms
Qing Hao acid; Artemisinic acid; Arteannuic acid
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvant et solubilité
DMSO : 100 mg/mL (426.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.83 mg/mL (3.54 mM); Clear solution
This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.83 mg/mL (3.54 mM); Clear solution
This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2675 mL | 21.3374 mL | 42.6749 mL | 106.6871 mL |
| 5 mM | 0.8535 mL | 4.2675 mL | 8.5350 mL | 21.3374 mL | |
| 10 mM | 0.4267 mL | 2.1337 mL | 4.2675 mL | 10.6687 mL | |
| 15 mM | 0.2845 mL | 1.4225 mL | 2.8450 mL | 7.1125 mL | |
| 20 mM | 0.2134 mL | 1.0669 mL | 2.1337 mL | 5.3344 mL | |
| 25 mM | 0.1707 mL | 0.8535 mL | 1.7070 mL | 4.2675 mL | |
| 30 mM | 0.1422 mL | 0.7112 mL | 1.4225 mL | 3.5562 mL | |
| 40 mM | 0.1067 mL | 0.5334 mL | 1.0669 mL | 2.6672 mL | |
| 50 mM | 0.0853 mL | 0.4267 mL | 0.8535 mL | 2.1337 mL | |
| 60 mM | 0.0711 mL | 0.3556 mL | 0.7112 mL | 1.7781 mL | |
| 80 mM | 0.0533 mL | 0.2667 mL | 0.5334 mL | 1.3336 mL | |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4267 mL | 1.0669 mL |
Artemisic acid Related Classifications
HY-N1984 Related Classifications
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