CDK12-IN-9
CDK12-IN-9 is a potent and selective CDK12 inhibitor with an IC50 of 2.2 nM. CDK12-IN-9 inhibits pSER2 (a downstream marker of CDK12/13 activity). CDK12-IN-9 can be used for the research of cancer.
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- CAS No.: 3024723-74-5
- Formule: C23H20F2N10
- Masse moléculaire:474.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK12 2.2 nM (IC50) |
CDK13 13 nM (IC50) |
CDK9 466 nM (IC50) |
CDK2 551 nM (IC50) |
CDK7 1491 nM (IC50) |
CDK12-IN-9 (Compound 17) potently inhibits purified CDK12 kinase with an IC50 of 2.2 ± 0.74 nM[1].
CDK12-IN-9 inhibits purified CDK13, CD9, CD7 and CD2 kinase with IC50 values of 13, 466, 1491 and 551 nM[1].
CDK12-IN-9 inhibits cellular pSER2 (a downstream marker of CDK12/13 activity) with an IC50 of 17 ± 4.1 nM[1].
CDK12-IN-9 inhibits pSER2 activity in whole blood with an IC50 of 209 ± 106 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3024723-74-5
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Masse moléculaire 474.47
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Formule C23H20F2N10
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SMILES
N#CC1=CC2=C(N(C=N2)[C@H]3CCC[C@H](C3)NC4=NC=C(C(C5=CN(N=C5)CC(F)F)=N4)C#N)N=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK12-IN-9 Related Classifications
HY-181645 Related Classifications
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