Divaricatol
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome.
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- CAS No.: 331433-08-0
- Formule: C17H18O7
- Masse moléculaire:334.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddy (Male, 4 weeks old, 24–36 g, acetic acid-induced writhing model)[1]
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Dosage:1, 5 mg/kg
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Administration:p.o.; single dose
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Result:Showed potent analgesic effect at oral doses of 1 and 5 mg/kg.
Chemical Information
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CAS No. 331433-08-0
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Masse moléculaire 334.32
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Formule C17H18O7
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SMILES
OC1=C2C(OC(C)([C@H](C2)OC(C)=O)C)=CC3=C1C(C=C(O3)CO)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001;49(2):154-160. [Content Brief]
[2]. Yu D, et al. Deciphering the microbiological mechanism of Tongxie Yaofang in treating IBS-D: a multimodal mechanistic study in mice integrating network pharmacology, computational simulation, and 16S rRNA sequencing. Exp Biol Med (Maywood). 2025;250:10725. Published 2025 Oct 3. [Content Brief]
[3]. Zhao Z, et al. Integration of serum metabolomics and network pharmacology reveals the immunoenhancing mechanisms of Qishenbuqi capsules. Toxicol Res (Camb). 2023;12(2):201-215. Published 2023 Feb 14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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