Cat. No.: HY-B0011A

Docetaxel Trihydrate

(Synonyms: RP-56976 Trihydrate)

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Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC₅₀ value of 0.2 μM. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis.

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Pureté: 99.91%
CAS No.: 148408-66-6
Formule: C₄₃H₅₉NO₁₇
Masse moléculaire:861.93

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Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Docetaxel Trihydrate Chemical Structure

CAS No.: 148408-66-6

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Description

Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC₅₀ value of 0.2 μM^[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis^[1]^[3].

IC₅₀ & Target

Microtubule^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	63.4 nM Compound: Docetaxel	Cytotoxicity against mouse triple negative 4T1 cells Cytotoxicity against mouse triple negative 4T1 cells	[PMID: 24890652]
A121	IC₅₀	1.2 nM Compound: docetaxel	Concentration required to inhibit growth of human tumor A121 (ovarian) cell line. Concentration required to inhibit growth of human tumor A121 (ovarian) cell line.	[PMID: 8831755]
A121	IC₅₀	1.2 nM Compound: Docetaxel	Growth inhibition of human ovarian carcinoma (A121) cell line Growth inhibition of human ovarian carcinoma (A121) cell line	[PMID: 9022793]
A121	IC₅₀	1.2 nM Compound: Docetaxel	Inhibition of the growth against human Ovarian Carcinoma (A121) cell line after 72 hr exposure Inhibition of the growth against human Ovarian Carcinoma (A121) cell line after 72 hr exposure	[PMID: 9022794]
A121	IC₅₀	1.2 nM Compound: Docetaxel	Cytotoxicity against human A121 ovarian cells Cytotoxicity against human A121 ovarian cells	10.1016/S0960-894X(01)80298-5
A121	IC₅₀	1.2 nM Compound: Docetaxel	Cytotoxicity was evaluated in vitro against A121 (ovarian carcinoma) human tumor cell lines Cytotoxicity was evaluated in vitro against A121 (ovarian carcinoma) human tumor cell lines	10.1016/S0960-894X(01)80568-0
A121	IC₅₀	1.2 nM Compound: Docetaxal	Cytotoxicity was evaluated against A121 ovarian carcinoma human cancer cell line Cytotoxicity was evaluated against A121 ovarian carcinoma human cancer cell line	10.1016/S0960-894X(96)00595-1
A2780	IC₅₀	0.5 nM Compound: 8	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 17206139]
A2780	IC₅₀	0.6 nM Compound: 1b	Cytotoxicity against human A2780 cells after 48 hrs by MTT assay Cytotoxicity against human A2780 cells after 48 hrs by MTT assay	[PMID: 19128972]
A2780	IC₅₀	290 nM Compound: 1b	Cytotoxicity against p-glycoprotein expressing drug-resistant human A2780 cells after 48 hrs by MTT assay Cytotoxicity against p-glycoprotein expressing drug-resistant human A2780 cells after 48 hrs by MTT assay	[PMID: 19128972]
A2780	IC₅₀	126 nM Compound: Docetaxel	Antiproliferative against multidrug-resistant human A2780 cells after 72 hrs by MTT assay Antiproliferative against multidrug-resistant human A2780 cells after 72 hrs by MTT assay	[PMID: 24835987]
A2780	IC₅₀	33 nM Compound: Docetaxel	Antiproliferative against human A2780 cells after 72 hrs by MTT assay Antiproliferative against human A2780 cells after 72 hrs by MTT assay	[PMID: 24835987]
A2780	IC₅₀	0.6 nM Compound: Docetaxel	Cytotoxicity against human A2780 cells by MTT assay Cytotoxicity against human A2780 cells by MTT assay	[PMID: 25047938]
A2780	IC₅₀	1 nM Compound: docetaxel	Cytotoxicity against A2780-C25, oxaliplatin-resistant Ovarian carcinoma cell line Cytotoxicity against A2780-C25, oxaliplatin-resistant Ovarian carcinoma cell line	[PMID: 8831755]
A2780	IC₅₀	1.2 nM Compound: docetaxel	Cytotoxicity against A2780-WT, human ovarian carcinoma cell line Cytotoxicity against A2780-WT, human ovarian carcinoma cell line	[PMID: 8831755]
A2780	IC₅₀	1.4 nM Compound: docetaxel	Cytotoxicity against A2780-CP3, cisplatin-resistant Ovarian carcinoma cell line Cytotoxicity against A2780-CP3, cisplatin-resistant Ovarian carcinoma cell line	[PMID: 8831755]
A2780	IC₅₀	122 nM Compound: docetaxel	Cytotoxicity against A2780-DX5, Doxorubicin-resistant Ovarian carcinoma cell line Cytotoxicity against A2780-DX5, Doxorubicin-resistant Ovarian carcinoma cell line	[PMID: 8831755]
A2780	IC₅₀	1.8 nM Compound: taxotere	Concentration of compound to inhibit the growth of human A2780 ovarian carcinoma cells(in vitro) Concentration of compound to inhibit the growth of human A2780 ovarian carcinoma cells(in vitro)	[PMID: 9288161]
A2780 ADR	IC₅₀	285 nM Compound: 8	Cytotoxicity against human A2780AD cells Cytotoxicity against human A2780AD cells	[PMID: 17206139]
A2780 ADR	IC₅₀	290 nM Compound: Docetaxel	Cytotoxicity against human A2780AD cells by MTT assay Cytotoxicity against human A2780AD cells by MTT assay	[PMID: 25047938]
A549	IC₅₀	0.0041 μM Compound: 1b (Docetaxel)	Inhibitory activity against A549 lung cancer cell line Inhibitory activity against A549 lung cancer cell line	[PMID: 12031338]
A549	IC₅₀	0.098 μM Compound: 1b (Docetaxel)	Inhibitory activity against Taxol-resistant A549 lung cancer cell line Inhibitory activity against Taxol-resistant A549 lung cancer cell line	[PMID: 12031338]
A549	IC₅₀	1 nM Compound: Docetaxel	In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure	[PMID: 12477344]
A549	IC₅₀	1 nM Compound: 1b Docetaxel	Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h	[PMID: 15225730]
A549	IC₅₀	1 μM Compound: 2	inhibitory concentration against the growth of Non-small-cell lung carcinoma A549 cell line after 72 hr of exposure inhibitory concentration against the growth of Non-small-cell lung carcinoma A549 cell line after 72 hr of exposure	[PMID: 15501062]
A549	IC₅₀	7.2 nM Compound: 8	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 17206139]
A549	IC₅₀	>1.4 μg/mL Compound: docetaxel	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 17624790]
A549	IC₅₀	1.7 μM Compound: docetaxel	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 18226907]
A549	IC₅₀	4.95 x 10^-4 μM Compound: docetaxel	Cytotoxicity against human A549 cells after 96 hrs by microplate reader assay Cytotoxicity against human A549 cells after 96 hrs by microplate reader assay	[PMID: 19133778]
A549	IC₅₀	0.37 μM Compound: Taxotere	Cytotoxicity against human A549 cells after 72 hrs Cytotoxicity against human A549 cells after 72 hrs	[PMID: 20849074]
A549	IC₅₀	0.0012 μM Compound: Docetaxel	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 21470864]
A549	IC₅₀	850 nM Compound: 2, DTX, Taxotere	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24269481]
A549	IC₅₀	35.2 nM Compound: Docetaxel	Antiproliferative against human A549 cells after 72 hrs by MTT assay Antiproliferative against human A549 cells after 72 hrs by MTT assay	[PMID: 24835987]
A549	IC₅₀	1 nM Compound: docetaxel	Concentration required to inhibit growth of human tumor A549 (NSCL) cell line. Concentration required to inhibit growth of human tumor A549 (NSCL) cell line.	[PMID: 8831755]
A549	IC₅₀	1 nM Compound: Docetaxel	Growth inhibition of human non-small-lung carcinoma (A549) cell line Growth inhibition of human non-small-lung carcinoma (A549) cell line	[PMID: 9022793]
A549	IC₅₀	1 nM Compound: Docetaxel	Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 hr exposure Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 hr exposure	[PMID: 9022794]
A549	IC₅₀	27.256 μg/mL Compound: Docetaxel	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	10.1007/s00044-013-0582-8
A549	IC₅₀	1 nM Compound: Docetaxel	Cytotoxicity against human A549 non small cell lung cell lines Cytotoxicity against human A549 non small cell lung cell lines	10.1016/S0960-894X(01)80298-5
A549	IC₅₀	1 nM Compound: Docetaxel	Cytotoxicity was evaluated in vitro against A549 (non-small cell lung carcinoma) human tumor cell lines Cytotoxicity was evaluated in vitro against A549 (non-small cell lung carcinoma) human tumor cell lines	10.1016/S0960-894X(01)80568-0
A549	IC₅₀	1 nM Compound: Docetaxal	Cytotoxicity was evaluated against A549 non-small cell lung carcinoma human cancer cell line Cytotoxicity was evaluated against A549 non-small cell lung carcinoma human cancer cell line	10.1016/S0960-894X(96)00595-1
B16	ED₅₀	11 μM Compound: 2 (docetaxel)	The compound was tested for Cytotoxic concentration against B16 melanoma cells. The compound was tested for Cytotoxic concentration against B16 melanoma cells.	[PMID: 7562913]
B16	ED₅₀	27 μM Compound: 2 (docetaxel)	The compound was tested for Cytotoxic concentration against B16 melanoma cells relative to paclitaxel The compound was tested for Cytotoxic concentration against B16 melanoma cells relative to paclitaxel	[PMID: 7562913]
Bel-7402	IC₅₀	1.9 nM Compound: Docetaxel	Antiproliferative activity against human Bel7402 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human Bel7402 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
C6	IC₅₀	1 nM Compound: docetaxel	Cytotoxicity against Pgp deficient human LCC6 cells after 72 hrs by sulforhodamine B test Cytotoxicity against Pgp deficient human LCC6 cells after 72 hrs by sulforhodamine B test	[PMID: 18465846]
Calu-3	IC₅₀	0.1 μM Compound: docetaxel	Cytotoxicity against human Calu3 cells after 72 hrs by SRB assay Cytotoxicity against human Calu3 cells after 72 hrs by SRB assay	[PMID: 19028425]
Cancer cell lines	IC₅₀	1.7 nM Compound: 2 (docetaxel)	Inhibitory concentration required against MKN1 human stomach cancer cell line was determined Inhibitory concentration required against MKN1 human stomach cancer cell line was determined	[PMID: 10397492]
Cancer cell lines	IC₅₀	4.8 nM Compound: 2 (docetaxel)	Inhibitory concentration required against Colon320 human colon cancer cell line was determined Inhibitory concentration required against Colon320 human colon cancer cell line was determined	[PMID: 10397492]
COLO 205	IC₅₀	30.706 μg/mL Compound: Docetaxel	Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay	10.1007/s00044-013-0582-8
ECa-109 cell line	IC₅₀	2.6 μM Compound: docetaxel	Cytotoxicity against human Eca109 cells Cytotoxicity against human Eca109 cells	[PMID: 18701281]
HCC1806	IC₅₀	8.4 μM Compound: docetaxel	Cytotoxicity against human HCC1806 cells after 48 hrs by MTT assay Cytotoxicity against human HCC1806 cells after 48 hrs by MTT assay	[PMID: 22560315]
HCT-116	IC₅₀	0.0022 μM Compound: 1b	Concentration required for inhibition of 50% human colon HCT 116 cell line proliferation after 72 hr of incubation Concentration required for inhibition of 50% human colon HCT 116 cell line proliferation after 72 hr of incubation	[PMID: 15537348]
HCT-116	IC₅₀	0.004 μM Compound: docetaxel	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 15921419]
HCT-116	IC₅₀	0.18 nM Compound: 7	Antiproliferative activity against IC95 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay Antiproliferative activity against IC95 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	0.2 nM Compound: 7	Antiproliferative activity against IC50 biaryl selected human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay Antiproliferative activity against IC50 biaryl selected human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	0.23 nM Compound: 7	Antiproliferative activity against human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay Antiproliferative activity against human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	0.3 nM Compound: 7	Antiproliferative activity against human HCT116 cells after 72 hrs by Cell titer Glo assay Antiproliferative activity against human HCT116 cells after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	0.31 nM Compound: 7	Antiproliferative activity against IC50 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay Antiproliferative activity against IC50 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	0.35 nM Compound: 7	Antiproliferative activity against 3x IC95 biaryl selected human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay Antiproliferative activity against 3x IC95 biaryl selected human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	0.59 nM Compound: 7	Antiproliferative activity against IC95 biaryl selected human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay Antiproliferative activity against IC95 biaryl selected human HCT116 cells expressing Kinesin-like protein KIF11 D130V mutant after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	8.7 nM Compound: 7	Antiproliferative activity against 3x IC95 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay Antiproliferative activity against 3x IC95 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay	[PMID: 17922005]
HCT-116	IC₅₀	1.2 nM Compound: taxotere	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 19572612]
HCT-116	IC₅₀	0.5 nM Compound: docetaxel	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-116	IC₅₀	1.2 μM Compound: Taxotere	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 20481544]
HCT-116	IC₅₀	0.52 nM Compound: Taxotere	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 21142180]
HCT-116	IC₅₀	0.52 nM Compound: taxotere	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HCT-116	IC₅₀	5 x 10^-8 M Compound: Taxotere	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 23387796]
HCT-116	IC₅₀	5 x 10^-2 μM Compound: Taxotere	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 23387796]
HCT-116	IC₅₀	3 nM Compound: Docetaxel	In vitro inhibition of proliferation of human colon cancer line 116 after 72 hrs incubation. In vitro inhibition of proliferation of human colon cancer line 116 after 72 hrs incubation.	10.1016/S0960-894X(00)80075-X
HCT-15	IC₅₀	13 nM Compound: docetaxel	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-8	IC₅₀	3.07 μM Compound: docetaxel	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 18701281]
HEK293	IC₅₀	0.027 μM Compound: 17	Cytotoxicity against HEK293 cells Cytotoxicity against HEK293 cells	[PMID: 17485207]
HeLa	IC₅₀	3.03 μM Compound: docetaxel	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 18701281]
HeLa	IC₅₀	50.1 nM Compound: Docetaxel	Antiproliferative against human HeLa cells after 72 hrs by MTT assay Antiproliferative against human HeLa cells after 72 hrs by MTT assay	[PMID: 24835987]
Hep 3B2	IC₅₀	38.2 nM Compound: Docetaxel	Antiproliferative activity against human Hep3B after 72 hrs by CellTiter Glo assay Antiproliferative activity against human Hep3B after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
HepG2	IC₅₀	>400 μM Compound: Taxotere	Cytotoxicity against human HepG2 cells by SRB method Cytotoxicity against human HepG2 cells by SRB method	[PMID: 18181575]
HepG2	IC₅₀	>100 nM Compound: Docetaxel	Antiproliferative activity against human HepG2 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human HepG2 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
HL-60	IC₅₀	0.5 nM Compound: docetaxel	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
HL-60	IC₅₀	0.52 μM Compound: Taxotere	Cytotoxicity against human HL60 cells after 72 hrs Cytotoxicity against human HL60 cells after 72 hrs	[PMID: 20849074]
HL-60	IC₅₀	0.5 nM Compound: Taxotere	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	531 nM Compound: Taxotere	Cytotoxicity against human HL60R cells after 72 hrs by MTS assay Cytotoxicity against human HL60R cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	0.5 nM Compound: taxotere	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HT-29	IC₅₀	3.34 x 10^-4 μM Compound: docetaxel	Cytotoxicity against human HT-29 cells after 96 hrs by microplate reader assay Cytotoxicity against human HT-29 cells after 96 hrs by microplate reader assay	[PMID: 19133778]
HT-29	IC₅₀	1 nM Compound: docetaxel	Cytotoxicity against human HT-29 cells after 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs	[PMID: 19239240]
HT-29	IC₅₀	0.92 μM Compound: Taxotere	Cytotoxicity against human HT-29 cells after 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs	[PMID: 20849074]
HT-29	IC₅₀	0.00075 μM Compound: Docetaxel	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 21470864]
HT-29	IC₅₀	0.75 nM Compound: Docetaxel	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 21470864]
HT-29	IC₅₀	1.2 nM Compound: docetaxel	Concentration required to inhibit growth of human tumor HT-29 (colon) cell line. Concentration required to inhibit growth of human tumor HT-29 (colon) cell line.	[PMID: 8831755]
HT-29	IC₅₀	1.2 nM Compound: Docetaxel	Growth inhibition of human colon carcinoma (HT-29) cell line Growth inhibition of human colon carcinoma (HT-29) cell line	[PMID: 9022793]
HT-29	IC₅₀	1.2 nM Compound: Docetaxel	Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 hr exposure Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 hr exposure	[PMID: 9022794]
HT-29	IC₅₀	1.2 nM Compound: Docetaxel	Cytotoxicity against human colon HT-29 cell lines Cytotoxicity against human colon HT-29 cell lines	10.1016/S0960-894X(01)80298-5
HT-29	IC₅₀	1.2 nM Compound: Docetaxel	Cytotoxicity was evaluated in vitro against HT-29 (colon carcinoma) human tumor cell lines Cytotoxicity was evaluated in vitro against HT-29 (colon carcinoma) human tumor cell lines	10.1016/S0960-894X(01)80568-0
HT-29	IC₅₀	1.2 nM Compound: Docetaxal	Cytotoxicity was evaluated against HT-29 colon carcinoma human cancer cell line Cytotoxicity was evaluated against HT-29 colon carcinoma human cancer cell line	10.1016/S0960-894X(96)00595-1
Huh-7	IC₅₀	12.1 nM Compound: Docetaxel	Antiproliferative activity against human HuH7 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human HuH7 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
HUVEC	IC₅₀	56.7 nM Compound: Docetaxel	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 24890652]
IMR-32	IC₅₀	23.71 μg/mL Compound: Docetaxel	Cytotoxicity against human IMR32 cells after 72 hrs by MTT assay Cytotoxicity against human IMR32 cells after 72 hrs by MTT assay	10.1007/s00044-013-0582-8
J774	ED₅₀	0.05 μM Compound: 3a (Taxotere 10-OH)	In vitro cytotoxicity against J774.2 cells after 72 hr incubation. In vitro cytotoxicity against J774.2 cells after 72 hr incubation.	10.1016/S0960-894X(01)80527-8
K562	IC₅₀	6.9 μg/mL Compound: docetaxel	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 17624790]
K562	IC₅₀	>400 μM Compound: Taxotere	Cytotoxicity against human K562 cells by SRB method Cytotoxicity against human K562 cells by SRB method	[PMID: 18181575]
K562	IC₅₀	8.5 μM Compound: docetaxel	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 18226907]
K562	IC₅₀	2.96 μM Compound: docetaxel	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 18701281]
KB	IC₅₀	0.0044 μM Compound: 1b (Docetaxel)	Inhibitory activity against KB nasopharynx cancer cell line Inhibitory activity against KB nasopharynx cancer cell line	[PMID: 12031338]
KB	IC₅₀	0.2 μM Compound: 1b (Docetaxel)	Inhibitory activity against Vincristine-resistant KB nasopharynx cancer cell line Inhibitory activity against Vincristine-resistant KB nasopharynx cancer cell line	[PMID: 12031338]
KB	IC₅₀	0.0003 μM Compound: 1b	Concentration required for inhibition of 50% human fibroblast KB cell line proliferation after 72 hr of incubation Concentration required for inhibition of 50% human fibroblast KB cell line proliferation after 72 hr of incubation	[PMID: 15537348]
KB	IC₅₀	0.3 nM Compound: 1b	Concentration required for inhibition of 50% human fibroblast KB cell line proliferation after 72 hr of incubation Concentration required for inhibition of 50% human fibroblast KB cell line proliferation after 72 hr of incubation	[PMID: 15537348]
KB	IC₅₀	0.002 μM Compound: docetaxel	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15921419]
KB	IC₅₀	0.2 nM Compound: Docetaxel	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 16989521]
KB	IC₅₀	0.0001 μM Compound: docetaxel, 1b	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 17064914]
KB	IC₅₀	0.1 nM Compound: docetaxel, 1b	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 17064914]
KB	IC₅₀	11.6 μg/mL Compound: docetaxel	Cytotoxicity against human KB cells by MTT assay Cytotoxicity against human KB cells by MTT assay	[PMID: 17624790]
KB	IC₅₀	1.14 nM Compound: Taxotere	Cytotoxicity against human KB cells by SRB method Cytotoxicity against human KB cells by SRB method	[PMID: 18181575]
KB	IC₅₀	1.14 x 10^-3 μM Compound: Taxotere	Cytotoxicity against human KB cells by SRB method Cytotoxicity against human KB cells by SRB method	[PMID: 18181575]
KB	IC₅₀	2.35 μM Compound: docetaxel	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 18701281]
KB	IC₅₀	0.0002 μM Compound: taxotere	Cytotoxicity against human KB cells after 72 hrs by neutral red staining Cytotoxicity against human KB cells after 72 hrs by neutral red staining	[PMID: 19053513]
KB	IC₅₀	0.2 nM Compound: taxotere	Cytotoxicity against human KB cells after 72 hrs by neutral red staining Cytotoxicity against human KB cells after 72 hrs by neutral red staining	[PMID: 19053513]
KB	IC₅₀	0.15 nM Compound: taxotere	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 19572612]
KB	IC₅₀	0.2 nM Compound: docetaxel	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
KB	IC₅₀	0.4 nM Compound: Taxotere	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 20053482]
KB	IC₅₀	0.15 μM Compound: Taxotere	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 20481544]
KB	IC₅₀	0.29 μM Compound: Taxotere	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 20849074]
KB	IC₅₀	0.17 nM Compound: Taxotere	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 21142180]
KB	IC₅₀	0.15 nM Compound: Taxotere	Cytotoxicity against human KB cells after 72 hrs by neutral red based colorimetry assay Cytotoxicity against human KB cells after 72 hrs by neutral red based colorimetry assay	[PMID: 21443172]
KB	IC₅₀	15 nM Compound: Taxotere	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 22050318]
KB	IC₅₀	0.17 nM Compound: taxotere	Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
KB	IC₅₀	0.00025 μM Compound: Taxotere	Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 23387796]
KB	IC₅₀	0.25 nM Compound: Taxotere	Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 23387796]
KB	IC₅₀	0.0002 μM Compound: Taxotere	Cytotoxicity activity against human KB cells Cytotoxicity activity against human KB cells	[PMID: 25478997]
KB	IC₅₀	0.2 nM Compound: Taxotere	Cytotoxicity activity against human KB cells Cytotoxicity activity against human KB cells	[PMID: 25478997]
KB 3-1	CC₅₀	0.25 nM Compound: Docetaxel	Cytotoxicity against human KB-3-1 cells after 72 hrs by MTS assay Cytotoxicity against human KB-3-1 cells after 72 hrs by MTS assay	[PMID: 18485536]
LLC-PK1	GI₅₀	0.17 nM Compound: Doc, Taxotere	Growth inhibition of pig LLC-PK1 cells by Alamar Blue assay Growth inhibition of pig LLC-PK1 cells by Alamar Blue assay	[PMID: 23956835]
LLC-PK1	GI₅₀	106.6 nM Compound: Doc, Taxotere	Growth inhibition of pig LLC-PK1 cells expressing MDR1 by Alamar Blue assay Growth inhibition of pig LLC-PK1 cells expressing MDR1 by Alamar Blue assay	[PMID: 23956835]
LoVo	IC₅₀	1.97 nM Compound: Taxotere	Cytotoxicity against human LoVo cells by SRB method Cytotoxicity against human LoVo cells by SRB method	[PMID: 18181575]
LoVo	IC₅₀	1.97 x 10^-3 μM Compound: Taxotere	Cytotoxicity against human LoVo cells by SRB method Cytotoxicity against human LoVo cells by SRB method	[PMID: 18181575]
MCF7	IC₅₀	1 nM Compound: Docetaxel	Inhibitory activity against the growth of MCF-7 (human breast carcinoma) cell line after 72 hours of drug exposure Inhibitory activity against the growth of MCF-7 (human breast carcinoma) cell line after 72 hours of drug exposure	[PMID: 10617084]
MCF7	IC₅₀	235 nM Compound: Docetaxel	Inhibitory activity against the growth of MCF-7R ( multi drug resistant human breast carcinoma) cell line after 72 hours of drug exposure Inhibitory activity against the growth of MCF-7R ( multi drug resistant human breast carcinoma) cell line after 72 hours of drug exposure	[PMID: 10617084]
MCF7	IC₅₀	0.0079 μM Compound: 1b (Docetaxel)	Inhibitory activity against MCF-7 breast cancer cell line Inhibitory activity against MCF-7 breast cancer cell line	[PMID: 12031338]
MCF7	IC₅₀	4.2 μM Compound: 1b (Docetaxel)	Inhibitory activity against Adriamycin-resistant MCF-7 breast cancer cell line Inhibitory activity against Adriamycin-resistant MCF-7 breast cancer cell line	[PMID: 12031338]
MCF7	IC₅₀	1 nM Compound: Docetaxel	In vitro cytotoxicity of compound against human MCF-7 (breast) cancer cell line after 72 hr of drug exposure In vitro cytotoxicity of compound against human MCF-7 (breast) cancer cell line after 72 hr of drug exposure	[PMID: 12477344]
MCF7	IC₅₀	1 nM Compound: 1b Docetaxel	Compound was tested for its cytotoxicity by inhibiting the growth of MCF-7 cell line after 72 h Compound was tested for its cytotoxicity by inhibiting the growth of MCF-7 cell line after 72 h	[PMID: 15225730]
MCF7	IC₅₀	1 μM Compound: 2	inhibitory concentration against the growth of breast cancer MCF-7 cell line after 72 hr of exposure inhibitory concentration against the growth of breast cancer MCF-7 cell line after 72 hr of exposure	[PMID: 15501062]
MCF7	IC₅₀	0.001 μM Compound: 1b	Concentration required for inhibition of 50% human breast MCF 7 cell line proliferation after 72 hr of incubation Concentration required for inhibition of 50% human breast MCF 7 cell line proliferation after 72 hr of incubation	[PMID: 15537348]
MCF7	IC₅₀	0.02 μM Compound: docetaxel	Cytotoxicity against doxorubicin-sensitive human MCF7 cells Cytotoxicity against doxorubicin-sensitive human MCF7 cells	[PMID: 15921419]
MCF7	IC₅₀	3.3 μg/mL Compound: docetaxel	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 17624790]
MCF7	IC₅₀	4 μM Compound: docetaxel	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 18226907]
MCF7	IC₅₀	1 nM Compound: docetaxel	Cytotoxicity against Pgp deficient human MCF7 cells after 72 hrs by sulforhodamine B test Cytotoxicity against Pgp deficient human MCF7 cells after 72 hrs by sulforhodamine B test	[PMID: 18465846]
MCF7	IC₅₀	3.29 μM Compound: docetaxel	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 18701281]
MCF7	IC₅₀	1 nM Compound: docetaxel	Cytotoxicity against P-glycoprotein deficient wild type human MCF7 cells after 72 hrs Cytotoxicity against P-glycoprotein deficient wild type human MCF7 cells after 72 hrs	[PMID: 19239240]
MCF7	IC₅₀	215 nM Compound: docetaxel	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs	[PMID: 19239240]
MCF7	IC₅₀	0.7 nM Compound: taxotere	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 19572612]
MCF7	IC₅₀	11.9 μM Compound: docetaxel	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22560315]
MCF7	IC₅₀	180 nM Compound: Docetaxel	Antiproliferative against multidrug-resistant human MCF7 cells after 72 hrs by MTT assay Antiproliferative against multidrug-resistant human MCF7 cells after 72 hrs by MTT assay	[PMID: 24835987]
MCF7	IC₅₀	38.53 nM Compound: Docetaxel	Antiproliferative against human MCF7 cells after 72 hrs by MTT assay Antiproliferative against human MCF7 cells after 72 hrs by MTT assay	[PMID: 24835987]
MCF7	IC₅₀	59.3 nM Compound: Docetaxel	Cytotoxicity against human ER-positive MCF7 cells Cytotoxicity against human ER-positive MCF7 cells	[PMID: 24890652]
MCF7	IC₅₀	>1000 nM Compound: Docetaxel	Cytotoxicity against human taxoid-resistant MCF7 cells Cytotoxicity against human taxoid-resistant MCF7 cells	[PMID: 24890652]
MCF7	IC₅₀	1 nM Compound: Docetaxel	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 25047938]
MCF7	IC₅₀	139.8 μM Compound: Docetaxel	Cytotoxicity against human MCF7 cells over-expressing CYP1B1 after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells over-expressing CYP1B1 after 48 hrs by MTT assay	[PMID: 25799264]
MCF7	IC₅₀	27.6 μM Compound: Docetaxel	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 25799264]
MCF7	IC₅₀	0.005 μM Compound: DOC	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 25817774]
MCF7	IC₅₀	1 nM Compound: docetaxel	Concentration required to inhibit growth of human tumor MCF-7 (breast) cell line. Concentration required to inhibit growth of human tumor MCF-7 (breast) cell line.	[PMID: 8831755]
MCF7	IC₅₀	235 nM Compound: docetaxel	Concentration required to inhibit growth of human tumor MFC7-R (breast) cell line. Concentration required to inhibit growth of human tumor MFC7-R (breast) cell line.	[PMID: 8831755]
MCF7	IC₅₀	1 nM Compound: Docetaxel	Growth inhibition of human mammary carcinoma (MCF-7) cell line Growth inhibition of human mammary carcinoma (MCF-7) cell line	[PMID: 9022793]
MCF7	IC₅₀	1 nM Compound: Docetaxel	Inhibition of the growth against human mammary carcinoma (MCF-7) cell line after 72 hr exposure Inhibition of the growth against human mammary carcinoma (MCF-7) cell line after 72 hr exposure	[PMID: 9022794]
MCF7	IC₅₀	1 nM Compound: Docetaxel	Cytotoxicity against human breast MCF-7 cancer cell lines Cytotoxicity against human breast MCF-7 cancer cell lines	10.1016/S0960-894X(01)80298-5
MCF7	IC₅₀	235 nM Compound: Docetaxel	Cytotoxicity against adriamycin resistant human breast MCF-7 cancer cell lines Cytotoxicity against adriamycin resistant human breast MCF-7 cancer cell lines	10.1016/S0960-894X(01)80298-5
MCF7	IC₅₀	1 nM Compound: Docetaxel	Cytotoxicity was evaluated in vitro against MCF-7 (mammary carcinoma) human tumor cell lines Cytotoxicity was evaluated in vitro against MCF-7 (mammary carcinoma) human tumor cell lines	10.1016/S0960-894X(01)80568-0
MCF7	IC₅₀	1 nM Compound: Docetaxal	Cytotoxicity was evaluated against MCF-7 mammary carcinoma human breast cancer cell line Cytotoxicity was evaluated against MCF-7 mammary carcinoma human breast cancer cell line	10.1016/S0960-894X(96)00595-1
MCF7R	IC₅₀	723 nM Compound: Docetaxel	Cytotoxicity against human mammary tumor cell line MCF7-R Cytotoxicity against human mammary tumor cell line MCF7-R	[PMID: 16298526]
MCF7R	IC₅₀	235 nM Compound: Docetaxel	Cytotoxicity against human MCF7/R cells by MTT assay Cytotoxicity against human MCF7/R cells by MTT assay	[PMID: 25047938]
MCF7R	IC₅₀	235 nM Compound: Docetaxel	Growth inhibition of human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line Growth inhibition of human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line	[PMID: 9022793]
MCF7R	IC₅₀	235 nM Compound: Docetaxel	Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 hr exposure Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 hr exposure	[PMID: 9022794]
MCF7R	IC₅₀	235 nM Compound: Docetaxal	Cytotoxicity was evaluated against MCF7-R (mammary carcinoma 180-fold resistant to doxorubicin, expressing MDR phenotype) human breast cancer cell line Cytotoxicity was evaluated against MCF7-R (mammary carcinoma 180-fold resistant to doxorubicin, expressing MDR phenotype) human breast cancer cell line	10.1016/S0960-894X(96)00595-1
MCF7S	IC₅₀	1 nM Compound: Docetaxel	Cytotoxicity against human mammary tumor cell line MCF7-S Cytotoxicity against human mammary tumor cell line MCF7-S	[PMID: 16298526]
MDA-MB-231	IC₅₀	0.018 nM Compound: Taxotere	Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay	[PMID: 21142180]
MDA-MB-231	IC₅₀	1 nM Compound: DTX	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 24564494]
MDA-MB-231	IC₅₀	16 nM Compound: Docetaxel	Cytotoxicity against human triple negative MDA-MB-231 cells Cytotoxicity against human triple negative MDA-MB-231 cells	[PMID: 24890652]
MDA-MB-435	IC₅₀	0.25 nM Compound: Taxotere	Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay	[PMID: 21142180]
MDA-MB-435	IC₅₀	2.7 nM Compound: Docetaxel	Cytotoxicity against human MDA-MB-435 cells Cytotoxicity against human MDA-MB-435 cells	[PMID: 24890652]
MDA-MB-468	IC₅₀	69.1 nM Compound: Docetaxel	Cytotoxicity against human triple negative MDA-MB-468 cells Cytotoxicity against human triple negative MDA-MB-468 cells	[PMID: 24890652]
MHCC97H	IC₅₀	22.4 nM Compound: Docetaxel	Antiproliferative activity against human MHCC97H after 72 hrs by CellTiter Glo assay Antiproliferative activity against human MHCC97H after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
MRC5	IC₅₀	0.0005 μM Compound: Taxotere	Cytotoxicity activity against human MRC5 cells Cytotoxicity activity against human MRC5 cells	[PMID: 25478997]
MRC5	IC₅₀	0.5 nM Compound: Taxotere	Cytotoxicity activity against human MRC5 cells Cytotoxicity activity against human MRC5 cells	[PMID: 25478997]
MX1	IC₅₀	0.14 nM Compound: docetoxel	Displacement of [125I]JV1-42 from GHRH receptor expressed in human MX1 cells Displacement of [125I]JV1-42 from GHRH receptor expressed in human MX1 cells	[PMID: 17261802]
NCI/ADR-RES	IC₅₀	235 nM Compound: Docetaxel	In vitro cytotoxicity of compound against human MCF-7-MDR (breast) cancer cell line after 72 hr of drug exposure In vitro cytotoxicity of compound against human MCF-7-MDR (breast) cancer cell line after 72 hr of drug exposure	[PMID: 12477344]
NCI/ADR-RES	GI₅₀	196 nM Compound: Doc, Taxotere	Growth inhibition of P-gp expressing human NCI-ADR-RES cells by Alamar Blue assay Growth inhibition of P-gp expressing human NCI-ADR-RES cells by Alamar Blue assay	[PMID: 23956835]
NCI/ADR-RES	IC₅₀	5.18 μM Compound: DOC	Cytotoxicity against human MCF7/ADR cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human MCF7/ADR cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 25817774]
NCI-H460	IC₅₀	0.0097 μM Compound: docetaxel	Cytotoxicity against human NCI-H460 cells after 72 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 72 hrs by SRB assay	[PMID: 19028425]
OVCAR-3	IC₅₀	1.2 nM Compound: 2 (docetaxel)	Inhibitory concentration required against OVCAR-3 human ovarian cancer cell line was determined Inhibitory concentration required against OVCAR-3 human ovarian cancer cell line was determined	[PMID: 10397492]
OVCAR-8	GI₅₀	0.5 nM Compound: Doc, Taxotere	Growth inhibition of human OVCAR8 cells by Alamar Blue assay Growth inhibition of human OVCAR8 cells by Alamar Blue assay	[PMID: 23956835]
P388	GI₅₀	0.78 ng/mL Compound: Docetaxel	Cytotoxic activity against mouse leukemia P388 cell line Cytotoxic activity against mouse leukemia P388 cell line	[PMID: 12482420]
P388	IC₅₀	0.13 μg/mL Compound: 13a	The concentration required to 50% inhibition of the P388 leukemic cell proliferation The concentration required to 50% inhibition of the P388 leukemic cell proliferation	[PMID: 1672159]
P388	IC₅₀	2 nM Compound: docetaxel	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18651728]
P388	IC₅₀	277 nM Compound: docetaxel	Cytotoxicity against adriamycin-resistant mouse P388 cells expressing p-glycoprotein Cytotoxicity against adriamycin-resistant mouse P388 cells expressing p-glycoprotein	[PMID: 18651728]
P388	IC₅₀	0.008 μg/mL Compound: docetaxel	In vitro cytotoxicity against murine P388 leukemia cell line In vitro cytotoxicity against murine P388 leukemia cell line	[PMID: 7914541]
P388	IC₅₀	1.5 μg/mL Compound: docetaxel	In vitro cytotoxicity against murine P388 doxorubicin resistant leukemia cell line In vitro cytotoxicity against murine P388 doxorubicin resistant leukemia cell line	[PMID: 7914541]
P388	GI₅₀	6.74 ng/mL Compound: 2 (Docetaxel)	Concentration required to inhibit the growth of mouse leukemia (P388) cell lines by 50% on 72 h continuous exposure Concentration required to inhibit the growth of mouse leukemia (P388) cell lines by 50% on 72 h continuous exposure	[PMID: 9871592]
P388	IC₅₀	0.04 μg/mL Compound: 2 (docetaxel)	In vitro cytotoxicity against murine P388 lymphocytic leukemia cells In vitro cytotoxicity against murine P388 lymphocytic leukemia cells	10.1016/0960-894X(95)00118-D
P388	IC₅₀	1.86 μM Compound: Docetaxel	In vitro cytotoxicity against doxorubicin resistant P388 cell lines In vitro cytotoxicity against doxorubicin resistant P388 cell lines	10.1016/S0960-894X(01)80298-5
P388	IC₅₀	9.9 nM Compound: Docetaxel	In vitro cytotoxicity against murine P388 cell lines In vitro cytotoxicity against murine P388 cell lines	10.1016/S0960-894X(01)80298-5
P388	GI₅₀	1.62 ng/mL Compound: 2	Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against mouse leukemia P388 Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against mouse leukemia P388	10.1016/S0960-894X(97)10128-7
PC-12	GI₅₀	11.7 ng/mL Compound: 2	Cytotoxic activity against PC-12 human non-small cell lung cancer cell line Cytotoxic activity against PC-12 human non-small cell lung cancer cell line	[PMID: 11212122]
PC-12	GI₅₀	11.7 ng/mL Compound: 2 (Docetaxel)	Growth inhibition of 50% of human non-small cell lung cancer (PC-12) cell line in MTT assay; 11.7-72.7 Growth inhibition of 50% of human non-small cell lung cancer (PC-12) cell line in MTT assay; 11.7-72.7	[PMID: 11909723]
PC-12	GI₅₀	42.2 ng/mL Compound: 2 (Docetaxel)	Concentration required to obtain half of the maximal inhibition for cell growth in human non-small cell lung cancer cell line(PC-12) was determined by using MTT assay when the cells were exposed to compound for 72 hr Concentration required to obtain half of the maximal inhibition for cell growth in human non-small cell lung cancer cell line(PC-12) was determined by using MTT assay when the cells were exposed to compound for 72 hr	[PMID: 12270153]
PC-12	GI₅₀	14.9 ng/mL Compound: Docetaxel	Cytotoxic activity against human lung cancer PC-12 cell line Cytotoxic activity against human lung cancer PC-12 cell line	[PMID: 12482420]
PC-12	GI₅₀	53.4 ng/mL Compound: 2 (Docetaxel)	Concentration required to inhibit the growth of human lung cancer (PC-12)cell lines by 50% on 72 hr continuous exposure Concentration required to inhibit the growth of human lung cancer (PC-12)cell lines by 50% on 72 hr continuous exposure	[PMID: 9871592]
PC-12	GI₅₀	19.1 ng/mL Compound: 2	Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against human lung cancer cell line PC-12 Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against human lung cancer cell line PC-12	10.1016/S0960-894X(97)10128-7
PC-3	IC₅₀	54.8 μM Compound: docetaxel	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 18226907]
PC-3	IC₅₀	2.77 μM Compound: docetaxel	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 18701281]
PC-3	IC₅₀	1.4 nM Compound: Taxotere	Cytotoxicity against human PC3 cells after 72 hrs by MTS assay Cytotoxicity against human PC3 cells after 72 hrs by MTS assay	[PMID: 21142180]
PC-3	GI₅₀	2.5 nM Compound: Doc, Taxotere	Growth inhibition of human PC3 cells after 72 hrs by Alamar Blue assay Growth inhibition of human PC3 cells after 72 hrs by Alamar Blue assay	[PMID: 23956835]
PC-3	GI₅₀	54 nM Compound: Doc, Taxotere	Growth inhibition of P-gp expressing docetaxel-resistant human PC3 cells after 72 hrs by Alamar Blue assay Growth inhibition of P-gp expressing docetaxel-resistant human PC3 cells after 72 hrs by Alamar Blue assay	[PMID: 23956835]
PC-6	GI₅₀	0.408 ng/mL Compound: 2	Cytotoxic activity against PC-6 human small cell lung cancer Cytotoxic activity against PC-6 human small cell lung cancer	[PMID: 11212122]
PC-6	GI₅₀	39.6 ng/mL Compound: 2	Cytotoxic activity against PC-6/VCR29-9 vincristine resistant cell line expressing P-gp Cytotoxic activity against PC-6/VCR29-9 vincristine resistant cell line expressing P-gp	[PMID: 11212122]
PC-6	GI₅₀	0.408 ng/mL Compound: 2 (Docetaxel)	Growth inhibition of 50% of human small cell lung cancer (PC-6) cell line in MTT assay; 0.408-2.55 Growth inhibition of 50% of human small cell lung cancer (PC-6) cell line in MTT assay; 0.408-2.55	[PMID: 11909723]
PC-6	GI₅₀	39.6 ng/mL Compound: 2 (Docetaxel)	Growth inhibition of 50% of vincristine-resistant cell line expressing P-glycoprotein (PC-6/VCR) in MTT assay; 39.6-230 Growth inhibition of 50% of vincristine-resistant cell line expressing P-glycoprotein (PC-6/VCR) in MTT assay; 39.6-230	[PMID: 11909723]
PC-6	GI₅₀	1.48 ng/mL Compound: 2 (Docetaxel)	Concentration required to obtain half of the maximal inhibition for cell growth in human small cell lung cancer(PC-6) was determined by using MTT assay when the cells were exposed to compound for 72 hr Concentration required to obtain half of the maximal inhibition for cell growth in human small cell lung cancer(PC-6) was determined by using MTT assay when the cells were exposed to compound for 72 hr	[PMID: 12270153]
PC-6	GI₅₀	135 ng/mL Compound: 2 (Docetaxel)	Concentration required to obtain half of the maximal inhibition for cell growth in vincristine-resistant cell line expressing P-glycoprotein (PC-6/VCR29-9) was determined by using MTT assay when the cells were exposed to compound for 72 hr Concentration required to obtain half of the maximal inhibition for cell growth in vincristine-resistant cell line expressing P-glycoprotein (PC-6/VCR29-9) was determined by using MTT assay when the cells were exposed to compound for 72 hr	[PMID: 12270153]
PC-6	GI₅₀	0.41 ng/mL Compound: Docetaxel	Cytotoxic activity against human lung cancer PC-6 cell line Cytotoxic activity against human lung cancer PC-6 cell line	[PMID: 12482420]
PC-6	GI₅₀	1.13 ng/mL Compound: 2 (Docetaxel)	Concentration required to inhibit the growth of human lung cancer (PC-6)cell lines by 50% on 72 hr continuous exposure Concentration required to inhibit the growth of human lung cancer (PC-6)cell lines by 50% on 72 hr continuous exposure	[PMID: 9871592]
PC-6	GI₅₀	1.16 ng/mL Compound: 2	Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against human lung cancer cell line PC-6 Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against human lung cancer cell line PC-6	10.1016/S0960-894X(97)10128-7
PC-6	GI₅₀	173 ng/mL Compound: 2	Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against vincristine resistant cancer cell line PC-6/VCR Compound was tested for growth inhibitory activity after 72 hr of continuous exposure against vincristine resistant cancer cell line PC-6/VCR	10.1016/S0960-894X(97)10128-7
PLC-PRF-5	IC₅₀	12 nM Compound: Docetaxel	Antiproliferative activity against human PLC/PRF/5 cells Antiproliferative activity against human PLC/PRF/5 cells	[PMID: 22320354]
PLC-PRF-5	IC₅₀	16.7 nM Compound: Docetaxel	Antiproliferative activity against human PLC/PRF/5 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human PLC/PRF/5 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SGC-7901	IC₅₀	0.0084 μM Compound: docetaxel	Cytotoxicity against human SGC7901 cells after 72 hrs by SRB assay Cytotoxicity against human SGC7901 cells after 72 hrs by SRB assay	[PMID: 19028425]
SK-BR-3	IC₅₀	4.7 nM Compound: 2 (docetaxel)	Inhibitory concentration required against SK-BR-3 human breast cancer cell line was determined Inhibitory concentration required against SK-BR-3 human breast cancer cell line was determined	[PMID: 10397492]
SK-LU-1	IC₅₀	1.8 nM Compound: 2 (docetaxel)	Inhibitory concentration required against SK-LU-1 human lung cancer cell line was determined Inhibitory concentration required against SK-LU-1 human lung cancer cell line was determined	[PMID: 10397492]
SK-OV-3	IC₅₀	3.4 nM Compound: Docetaxel	Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay	[PMID: 18524425]
SK-OV-3	IC₅₀	3.4 x 10^-3 μM Compound: Docetaxel	Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay	[PMID: 18524425]
SK-OV-3	IC₅₀	2.35 μM Compound: docetaxel	Cytotoxicity against human SKOV3 cells Cytotoxicity against human SKOV3 cells	[PMID: 18701281]
SK-OV-3	IC₅₀	0.51 nM Compound: Taxotere	Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay	[PMID: 21142180]
SK-OV-3	IC₅₀	5 nM Compound: 2, DTX, Taxotere	Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 24269481]
SMMC-7721	IC₅₀	2.73 μM Compound: docetaxel	Cytotoxicity against human SMMC7721 cells Cytotoxicity against human SMMC7721 cells	[PMID: 18701281]
SMMC-7721	IC₅₀	2 nM Compound: Docetaxel	Antiproliferative activity against human SMMC7721 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SMMC7721 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SNU-182	IC₅₀	39.2 nM Compound: Docetaxel	Antiproliferative activity against human SNU182 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SNU182 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SNU-387	IC₅₀	4.3 nM Compound: Docetaxel	Antiproliferative activity against human SNU387 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SNU387 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SNU-398	IC₅₀	16.6 nM Compound: Docetaxel	Antiproliferative activity against human SNU398 cells Antiproliferative activity against human SNU398 cells	[PMID: 22320354]
SNU-398	IC₅₀	17.6 nM Compound: Docetaxel	Antiproliferative activity against human SNU398 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SNU398 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SNU-423	IC₅₀	10.8 nM Compound: Docetaxel	Antiproliferative activity against human SNU423 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SNU423 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SNU-449	IC₅₀	>100 nM Compound: Docetaxel	Antiproliferative activity against human SNU449 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SNU449 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
SNU-475	IC₅₀	20.5 nM Compound: Docetaxel	Antiproliferative activity against human SNU475 after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SNU475 after 72 hrs by CellTiter Glo assay	[PMID: 22320354]
U-87MG ATCC	IC₅₀	20.72 μg/mL Compound: Docetaxel	Cytotoxicity against human U87 cells after 72 hrs by MTT assay Cytotoxicity against human U87 cells after 72 hrs by MTT assay	10.1007/s00044-013-0582-8
WI-38	IC₅₀	>10 μM Compound: docetaxel	Cytotoxicity against human WI38 cells after 72 hrs by SRB assay Cytotoxicity against human WI38 cells after 72 hrs by SRB assay	[PMID: 19028425]
WiDr	IC₅₀	0.43 nM Compound: 2 (docetaxel)	Inhibitory concentration required against WiDr human colon cancer cell line was determined Inhibitory concentration required against WiDr human colon cancer cell line was determined	[PMID: 10397492]

In Vitro

Docetaxel Trihydrate (RP-56976 Trihydrate) and Glufosfamide (GLU) single and combined treatments affect the cells viability in a dose-dependent manner. The IC₅₀ of GLU are 70±4 μM and 86.8±8 μM in PC-3 and LNCaP cells; respectively. While, the IC₅₀ of Docetaxel alone is found to be 3.08±0.4 nM and 1.46±0.2 nM in PC-3 and LNCaP cells; respectively. The co-treatment of GLU with Docetaxel is found to synergize the cytotoxicity and the IC₅₀ values are decreased to be 2.7±0.1 nM and 0.75±0.3 nM in PC-3 and LNCaP cells; respectively^[1]. IC₅₀ of NCI-H460 to Docetaxel at 24 h is 116 nM and at 72 h is 30 nM. According to data reported in DTP Data Search, the mean IC₅₀ of NCI-60 cell panel to Docetaxel is 14-34 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In female mice, the Docetaxel Trihydrate (RP-56976 Trihydrate)-induced intestinal apoptosis in the 14-hours after light on (HALO) group is significantly greater than that in the 2-HALO group. Bax expression is significantly elevated by Docetaxel in the 2-HALO group, but not in the 14-HALO group. On the other hand, cleaved Caspase-3 expression is significantly elevated by Docetaxel in the 14-HALO group, but not in the 2-HALO group. The expressions of Wee1 and phosphorylated CKD1 are significantly elevated after dosing of Docetaxel at 14 HALO, but not at 2 HALO. In addition, Docetaxel significantly reduces survivin expression in the 14-HALO group but not in the 2-HALO group. The survivin expression level in the Docetaxel-treated 14-HALO group is significantly smaller than that in the drug-treated 2-HALO group^[3]. Piperine (PIP) is administrated via intravenous bolus at 3.5 mg/kg and via oral administration at 35 mg/kg and 3.5 mg/kg, while Docetaxel (DOX) is intravenously administrated at 7 mg/kg to Sprague-Daley rats. The co-administrations of PIP at 35 mg/kg via oral administration and Docetaxel at 7 mg/kg via intravenous bolus administration in Sprague-Dawley rats. The combination use of PIP and Docetaxel results in a synergic increase of both their in vivo exposure^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 148408-66-6
Appearance Solid
Masse moléculaire 861.93
Formule C₄₃H₅₉NO₁₇
Color White to off-white
SMILES

O=C(OC(C)(C)C)N[C@H]([C@H](C(O[C@@H]1C(C)=C([C@@H](O)C([C@@]2(C)[C@]([C@@](CO3)(OC(C)=O)[C@@]3([H])C[C@@H]2O)([H])[C@@H]4OC(C5=CC=CC=C5)=O)=O)C(C)(C)[C@@]4(O)C1)=O)O)C6=CC=CC=C6.O.O.O
Synonyms

RP-56976 Trihydrate
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (165)

All Apoptosis AnalysisWBCell Proliferation/Viability Assay

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Signal Transduct Target Ther

Targeting oncogenic TβRI signaling inhibits androgen-independent prostate cancer growth and metastasis. [Abstract]

2026 Jun 17;11(1):238. PMID: 42303991
Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Signal Transduct Target Ther

Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation. [Abstract]

2022 Sep 12;7(1):317. PMID: 36097006
J Clin Oncol

2026 Mar 2.
J Hematol Oncol

Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis. [Abstract]

2023 May 3;16(1):46. PMID: 37138326

Docetaxel Trihydrate purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2023 May 3;16(1):46. [Abstract]

Under docetaxel treatment (0.5 nM, 1 nM, 2.5 nM, 5 nM, 10 nM, 20 nM, 48 hours), myeloid-like tumor hybrid cells were less sensitive than the RM1 cell line.
Mol Cancer

Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy. [Abstract]

2024 May 9;23(1):83. PMID: 38730475
Cancer Discov

Targeting KRAS codon 13 mutations using direct combination approaches in non-small cell lung cancer. [Abstract]

2026 Jun 22. PMID: 42329102
Adv Mater

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers. [Abstract]

2025 Jul 4:e2505231. PMID: 40611758
Eur Urol

Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment. [Abstract]

2020 Nov 2;S0302-2838(20)30778-8. PMID: 33153817
Adv Funct Mater

2023 Dec 15.
Cancer Res

Targeting Sialylation Enhances the Therapeutic Efficacy of the Nectin-4-Targeted Antibody-Drug Conjugate Enfortumab Vedotin in Bladder Cancer. [Abstract]

2025 Oct 9. PMID: 41066596
ACS Nano

Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy. [Abstract]

2021 Apr 27;15(4):7179-7194. PMID: 33861924
Sci Transl Med

TSPAN8+ myofibroblastic cancer-associated fibroblasts promote chemoresistance in patients with breast cancer. [Abstract]

2024 Apr 3;16(741):eadj5705. PMID: 38569015

Docetaxel Trihydrate purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2024 Apr 3;16(741):eadj5705. [Abstract]

Growth inhibition by docetaxel (Doc) (0–10 μM) in TS− or TS+ CAFs isolated from patients with BC was observed. The survival rates of TSPAN8+ CAFs were enhanced compared with TSPAN8− CAFs when challenged with an equal dosage of docetaxel.
Acta Pharm Sin B

Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy. [Abstract]

2021 Apr;11(4):1069-1082. PMID: 33996418
Adv Sci (Weinh)

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients. [Abstract]

2026 Mar;13(13):e11408. PMID: 41486873
Adv Sci (Weinh)

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer. [Abstract]

2024 Nov 20:e2407662. PMID: 39563492

Docetaxel Trihydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 20:e2407662. [Abstract]

Representative images and quantitative analysis of surviving clones after treatment of C4-2B and LNCaP cells with PBS or ECM1 protein (200 ng/mL) in the presence of docetaxel (10 μM) were shown.

Docetaxel Trihydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 20:e2407662. [Abstract]

Flow cytometry analysis showed representative images and quantification of apoptosis in C4-2B and LNCaP cells in the presence of docetaxel (10 μM). Docetaxel caused PCa cell apoptosis compared to that in the vehicle group.
J Clin Invest

Targeting Wnt/β-Catenin and circadian regulator restores PRC2/EZH2 controlled chromatin bivalency and suppresses cell state diversity. [Abstract]

2026 Mar 17:e200260. PMID: 41842971
Biomaterials

Sustained potentiation of bystander killing via PTEN-loss driven macropinocytosis targeted peptide-drug conjugate therapy in metastatic triple-negative breast cancer. [Abstract]

2022 Oct:289:121783. PMID: 36084486
J Exp Clin Cancer Res

LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network. [Abstract]

2023 Aug 18;42(1):209. PMID: 37596700
J Control Release

Macropinocytosis-targeted peptide-docetaxel conjugate for bystander pancreatic cancer treatment. [Abstract]

2024 Dec:376:829-841. PMID: 39491626
J Control Release

Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer. [Abstract]

2023 Jan:353:490-506. PMID: 36460179
Biomark Res

circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3. [Abstract]

2022 Jul 13;10(1):48. PMID: 35831872
J Control Release

Management of lymph node metastasis via local chemotherapy can prevent distant metastasis and improve survival in mice. [Abstract]

2021 Jan 10;329:847-857. PMID: 33065097
Genome Med

Genomic and transcriptomic analysis of breast cancer identifies novel signatures associated with response to neoadjuvant chemotherapy. [Abstract]

2024 Jan 12;16(1):11. PMID: 38217005
Cell Rep Med

Sex-biased intratumoral microbiome influences tumor molecular and immune landscape and disease outcomes. [Abstract]

2026 May 19;7(5):102757. PMID: 42013847
Cell Rep Med

A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma. [Abstract]

2026 Feb 17;7(2):102622. PMID: 41707653
Cell Rep Med

CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]

2025 Apr 2:102053. PMID: 40187357
Cell Rep Med

Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study. [Abstract]

2023 Feb 21;4(2):100911. PMID: 36657446
J Immunother Cancer

ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer. [Abstract]

2021 Jul;9(7):e001758. PMID: 34301812
Pharmacol Res

Time-dependent proteomics and drug response in expanding cancer cells. [Abstract]

2024 May 9:204:107208. PMID: 38729587
Mater Today Bio

Mannosylated graphene oxide nanotherapeutics co-delivering docetaxel and a STING agonist reprogram myeloid cells and potentiate antitumor immunity. [Abstract]

2026 Mar 31:38:103086. PMID: 42006712
Cancer Lett

Chemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications. [Abstract]

2024 Nov 26:217339. PMID: 39608442
Cancer Lett

The CAIX inhibitor SLC-0111 exerts anti-cancer activity on gastric cancer cell lines and resensitizes resistant cells to 5-Fluorouracil, taxane-derived, and platinum-based drugs. [Abstract]

2023 Sep 1:571:216338. PMID: 37549770
J Colloid Interface Sci

Smart dual responsive nanocarriers with reactive oxygen species amplification assisted synergistic chemotherapy against prostate cancer. [Abstract]

2022 May 2;622:789-803. PMID: 35544966
Cell Death Dis

AKT1 phosphorylates PRMT7 to promote GLUD1 methylation and gastric cancer progression. [Abstract]

2026 Mar 24;17(1):363. PMID: 41876450
Cell Death Dis

Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. [Abstract]

2025 Mar 12;16(1):170. PMID: 40075071
Cell Death Dis

Single-cell transcriptome profiles the heterogeneity of tumor cells and microenvironments for different pathological endometrial cancer and identifies specific sensitive drugs. [Abstract]

2024 Aug 7;15(8):571. PMID: 39112478
Proc Natl Acad Sci U S A

Computational drug discovery for castration-resistant prostate cancers through in vitro drug response modeling. [Abstract]

2023 Apr 25;120(17):e2218522120. PMID: 37068243
ACS Sens

Cryopreservable Through-Hole Arrays for the High-Throughput Three-Dimensional Smartphone-Based Cell Colorimetric Assay. [Abstract]

2023 Feb 24;8(2):543-554. PMID: 36705290
Phytomedicine

Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids. [Abstract]

2024 Dec:135:156155. PMID: 39461203
Phytomedicine

Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer. [Abstract]

2023 Aug:117:154921. PMID: 37327642
Phytomedicine

Compound K is a potential clinical anticancer agent in prostate cancer by arresting cell cycle. [Abstract]

2023 Jan:109:154584. PMID: 36610114
Phytomedicine

Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling. [Abstract]

2022 May:99:153939. PMID: 35172257
ACS Appl Mater Interfaces

Single-Cell Fluidic Force Spectroscopy Reveals Dynamic Mechanical Fingerprints of Malignancy in Breast Cancer. [Abstract]

2024 Sep 25;16(38):50147-50159. PMID: 39105773
ACS Appl Mater Interfaces

Glutathione and Esterase Dual-Responsive Smart Nano-drug Delivery System Capable of Breaking the Redox Balance for Enhanced Tumor Therapy. [Abstract]

2023 May 3;15(17):20697-20711. PMID: 37083309
Cancer Immunol Res

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]

2023 May 3;11(5):583-599. PMID: 36921097
Mater Sci Eng C Mater Biol Appl

Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy. [Abstract]

2021 Apr:123:111956. PMID: 33812584
Biofabrication

3D bioprinting of multi-cellular tumor microenvironment for prostate cancer metastasis. [Abstract]

2023 Jun 9;15(3). PMID: 37236173
Br J Pharmacol

A vitamin D-based strategy overcomes chemoresistance in prostate cancer. [Abstract]

2024 Nov;181(21):4279-4293. PMID: 38982588
Arch Pharm Res

Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition. [Abstract]

2024 Nov;47(10-11):829-853. PMID: 39482441
Biomed Pharmacother

Dual receptor specific nanoparticles targeting EGFR and PD-L1 for enhanced delivery of docetaxel in cancer therapy. [Abstract]

2023 Sep:165:115023. PMID: 37329708
Biomed Pharmacother

Patient-derived organoid culture of gastric cancer for disease modeling and drug sensitivity testing. [Abstract]

2023 Jul:163:114751. PMID: 37105073
Diabetes

FGF13-sensitive alteration of Parkin safeguards mitochondrial homeostasis in endothelium of diabetic nephropathy. [Abstract]

2023 Jan 1;72(1):97-111. PMID: 36256844
J Transl Int Med

Anti-SIA-cIgG enhances chemotherapy effectiveness through PTPN13-regulated tumor stemness in head and neck squamous cell carcinoma. [Abstract]

2026 Mar 26;14(2):237-258. PMID: 42046805
Cell Mol Gastroenterol Hepatol

Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. [Abstract]

2021;11(3):683-696. PMID: 33075564
Oncogene

HOMER3 drives oral squamous cell carcinoma progression through TRPV6 calcium influx and TUBB3 microtubule stabilization. [Abstract]

2026 Jan;45(2):278-294. PMID: 41326663
Oncogene

Targeting SREBP-dependent lipogenesis potentiates the anti-tumor activity of docetaxel by increasing membrane permeability and intracellular drug accumulation. [Abstract]

2025 Nov;44(45):4405-4412. PMID: 41046255
Cell Rep

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis. [Abstract]

2024 Jul 3;43(7):114431. PMID: 38968071
J Agric Food Chem

Eurochevalierines A - I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5. [Abstract]

2024 Jul 31;72(30):16801-16811. PMID: 39016690
Cell Biosci

Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair. [Abstract]

2023 Nov 25;13(1):215. PMID: 38007480
Cancer Cell Int

Organoids as a model system for researching human neuroendocrine tumor of the breast. [Abstract]

2024 Dec 27;24(1):433. PMID: 39731167
Cancer Cell Int

Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells. [Abstract]

2024 Jul 17;24(1):249. PMID: 39020371
Eur J Med Chem

Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance. [Abstract]

2018 Feb 25:146:157-170. PMID: 29407947
Int J Mol Med

Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway. [Abstract]

2024 Jul;54(1):60. PMID: 38785138
Breast Cancer Res

TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9. [Abstract]

2024 Mar 19;26(1):48. PMID: 38504374
Biochem Pharmacol

Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cells. [Abstract]

2020 May;175:113865. PMID: 32142727
Drug Deliv Transl Res

Surface-engineered nanostructured lipid carrier systems for synergistic combination oncotherapy of non-small cell lung cancer. [Abstract]

2021 Oct;11(5):2030-2051. PMID: 33215254
J Enzyme Inhib Med Chem

Integrating virtual screening and molecular dynamics simulations to identify emodin as a PYCR1 inhibitor modulating docetaxel sensitivity in prostate cancer. [Abstract]

2026 Dec;41(1):2622725. PMID: 41665114
Chem Biol Interact

The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis. [Abstract]

2023 Mar 1:373:110372. PMID: 36736488
Int J Pharm

Surface-modified nanoparticles of docetaxel for chemotherapy of lung cancer: an intravenous to oral switch. [Abstract]

2023 Apr 5:636:122846. PMID: 36921744
Life Sci

A protective role of ECSIT in chemotherapy-induced intestinal mucositis by maintaining Lgr5+ intestinal stem cells and gut homeostasis. [Abstract]

2026 Mar 15:389:124236. PMID: 41611204
Cancer Immunol Immunother

Construction and application of a humanized mouse model for prostate cancer in immunotherapy. [Abstract]

2025 Nov 18;74(12):377. PMID: 41251708
Microchem J

2025 Oct 15;218:115702.
J Pharm Investig

2025 Sep 19.
Life Sci

N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway. [Abstract]

2025 Apr 17:372:123646. PMID: 40250752
Life Sci

Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment. [Abstract]

2021 Jan 1;264:118674. PMID: 33129876
Life Sci

Arctigenin inhibits proliferation of ER-positive breast cancer cells through cell cycle arrest mediated by GSK3-dependent cyclin D1 degradation. [Abstract]

2020 Sep 1;256:117983. PMID: 32565252
Biol Direct

Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma. [Abstract]

2024 Sep 11;19(1):79. PMID: 39256753
Int J Mol Sci

Dual Inhibition of BRAF-MAPK and STAT3 Signaling Pathways in Resveratrol-Suppressed Anaplastic Thyroid Cancer Cells with BRAF Mutations. [Abstract]

2022 Nov 19;23(22):14385. PMID: 36430869
Int J Mol Sci

Potent Anti-Cancer Properties of Phthalimide-Based Curcumin Derivatives on Prostate Tumor Cells. [Abstract]

2019 Jan; 20(1): 28. PMID: 30577600
Pharmaceuticals (Basel)

Computational Modeling to Identify Drugs Targeting Metastatic Castration-Resistant Prostate Cancer Characterized by Heightened Glycolysis. [Abstract]

2024 Apr 29;17(5):569. PMID: 38794139
Int J Cancer

Establishment of patient-derived organoids for guiding personalized therapies in breast cancer patients. [Abstract]

2024 Jul 15;155(2):324-338. PMID: 38533706
Mol Oncol

Patient therapy outcome modeling in cancer organoids is improved by cancer-associated fibroblasts and organoid assembly convolution. [Abstract]

2026 Jun 5. PMID: 42246237
Cell Rep Methods

RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]

2023 Oct 23;3(10):100599. PMID: 37797618
BJU Int

Drug-releasing intravesical floating technology for sequential gemcitabine and docetaxel in non-muscle-invasive bladder cancer. [Abstract]

2025 Nov 3. PMID: 41178321
Clin Epigenetics

Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer. [Abstract]

2025 May 6;17(1):77. PMID: 40329330
Cancers

Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer. [Abstract]

2020 Jul 28;12(8):2092. PMID: 32731472
Pharm Res

Active Targeting of Colorectal Cancer Using Chemotherapy-Loaded Nanoparticles Functionalized with a Folate Receptor-α (FRα) Ligand, Pemetrexed. [Abstract]

2025 Nov 18. PMID: 41254319
ACS Omega

Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]

2024 Feb 28;9(10):11870-11882. PMID: 38496939
Cancer Sci

NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway. [Abstract]

2024 Feb;115(2):412-426. PMID: 38115797
J Liposome Res

Fabrication, optimization, and in vitro evaluation of docetaxel-loaded nanostructured lipid carriers for improved anticancer activity. [Abstract]

2020 Jun;30(2):182-196. PMID: 31060404
J Mol Med (Berl)

Tyrosine hydroxylase as a therapeutic target: insights from adrenergic nerve and TNBC cell interactions. [Abstract]

2026 Mar 19;104(1):53. PMID: 41857421
J Cell Mol Med

Anticancer Activity of Annonacin and Its Synergistic Enhancement of Docetaxel Efficacy in Prostate Cancer. [Abstract]

2025 Dec;29(23):e70972. PMID: 41328625
FEBS J

ABCB1-mediated docetaxel resistance reversed by erastin in prostate cancer. [Abstract]

2024 Jul;291(14):3249-3266. PMID: 38712529
J Cell Mol Med

Telmisartan anti-cancer activities mechanism through targeting N-cadherin by mimicking ADH-1 function. [Abstract]

2022 Apr;26(8):2392-2403. PMID: 35224849
iScience

Identifying CTSF and GSTM3 as chemoresistance therapeutic targets in breast cancer through multi-omics MR analysis. [Abstract]

2025 Oct 30;28(12):113908. PMID: 41321627
iScience

ALKBH5-IGF2BP2 axis mediates prostate cancer progression and docetaxel resistance via m6A-stabilized CLSPN RNA. [Abstract]

2025 Sep 9;28(10):113520. PMID: 41069850
Transl Oncol

MiR-138-5p inhibits prostate cancer cell proliferation and chemoresistance by targeting APOBEC3B. [Abstract]

2023 Sep:35:101723. PMID: 37364333
Sci Rep

Ring-finger protein RNF126 promotes prostate cancer progression via regulation of MBNL1. [Abstract]

2025 Jul 4;15(1):23847. PMID: 40615482
Sci Rep

Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation. [Abstract]

2024 Mar 27;14(1):7303. PMID: 38538642
Sci Rep

Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening. [Abstract]

2023 Jun 3;13(1):9043. PMID: 37270558
J Biol Chem

Androgen receptor splicing variant 7 (ARV7) inhibits docetaxel sensitivity by inactivating the spindle assembly checkpoint. [Abstract]

2021 Jan-Jun:296:100276. PMID: 33428943
Biochim Biophys Acta Mol Cell Res

Cancer-associated fibroblasts secreting IL-6 inhibit the cisplatin and docetaxel killing effect in lung squamous cell carcinoma. [Abstract]

2025 Jul 31;1872(8):120029. PMID: 40752594
PLoS Genet

Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironment. [Abstract]

2025 Mar 31;21(3):e1011652. PMID: 40163511
Transl Lung Cancer Res

Construction of a lung cancer 3D culture model based on alginate/gelatin micro-beads for drug evaluation. [Abstract]

2024 Oct 31;13(10):2698-2712. PMID: 39507032
Mol Med Rep

miR‑133b affects cell proliferation, invasion and chemosensitivity in renal cell carcinoma by inhibiting the ERK signaling pathway. [Abstract]

2020 Jul;22(1):67-76. PMID: 32377748
Eur J Med Res

Long non-coding RNA NORAD serves as a promoter of oncogenesis and inhibits ferroptosis via miR-144-3p-mTOR-ferritinophagy axis in cancer. [Abstract]

2025 Aug 4;30(1):704. PMID: 40760677
BMC Cancer

Platycodin D-mediated METTL16 downregulation promotes docetaxel treatment of prostate cancer by regulating ferroptosis. [Abstract]

2025 Jul 1;25(1):1042. PMID: 40597047
Chem Biol Drug Des

Polyphyllin VII Enhances the Sensitivity of Prostate Cancer Cells to Docetaxel by Promoting Mitochondrial Dysfunction and Inducing Ferroptosis. [Abstract]

2025 Feb;105(2):e70053. PMID: 39871642
Front Oncol

Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer. [Abstract]

2019 Dec 19;9:1398. PMID: 31921655
Int J Med Sci

Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer. [Abstract]

2026 Jan 1;23(1):161-176. PMID: 41399371
Pathol Res Pract

Alendronate-functionalized ZIF-8 nanoplatform for targeted delivery of SHH siRNA and docetaxel to treat prostate cancer bone metastasis. [Abstract]

2025 Sep:273:156138. PMID: 40694986
Mol Carcinog

ZNF480 Accelerates Chemotherapy Resistance in Breast Cancer by Competing With TRIM28 and Stabilizing LSD1 to Upregulate the AKT-GSK3β-Snail Pathway. [Abstract]

2025 Jan;64(1):192-208. PMID: 39503216
J Microencapsul

Fabrication, optimisation and in vitro evaluation of docetaxel and curcumin Co-loaded nanostructured lipid carriers for improved antitumor activity against non-small cell lung carcinoma. [Abstract]

2020 Dec;37(8):543-556. PMID: 32924677
Materials

Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts. [Abstract]

2020 Mar 2;13(5):1099. PMID: 32121631
J Microencapsul

Docetaxel-loaded PAMAM-based poly (γ-benzyl-l-glutamate)-b-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles in human breast cancer and human cervical cancer therapy. [Abstract]

2019 Sep;36(6):552-565. PMID: 31403342
Front Biosci (Landmark Ed)

Hypoxia-Induced VGF Promotes Cell Migration and Invasion in Prostate Cancer via the PI3K/Akt Axis. [Abstract]

2025 Feb 20;30(2):25522. PMID: 40018933
Micromachines

Integrated Experimental-Computational Framework for Drug Transport Quantification in 3D Microtissues™. [Abstract]

2026 Mar 9;17(3):332. PMID: 41900218
Breast Cancer Res Treat

Organoid models derived from patients with malignant phyllodes tumor of the breast. [Abstract]

2023 Jul;200(2):193-201. PMID: 37204665
Arch Biochem Biophys

KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation. [Abstract]

2023 Mar 15:737:109551. PMID: 36822388

Docetaxel Trihydrate purchased from MedChemExpress. Usage Cited in: Arch Biochem Biophys. 2023 Mar 15:737:109551. [Abstract]

Docetaxel (30 nM) exhibits anti-tumor activity in parental (DU145 and PC-3) and docetaxel-resistant (DU145/DTX50 and PC-3/DTX30) cell lines by down-regulating KIF14 expression.
Breast Cancer

Quercetin Promote the Chemosensitivity in Organoids Derived from Patients with Breast Cancer. [Abstract]

2024 Dec 20:16:993-1004. PMID: 39720358
Discov Oncol

Targeting XPO6 inhibits prostate cancer progression and enhances the suppressive efficacy of docetaxel. [Abstract]

2023 May 27;14(1):82. PMID: 37243787
Reprod Toxicol

Protective effects of rutin against docetaxel-induced testicular damage in rats: Effects on antioxidant defence, apoptosis and autophagy. [Abstract]

2026 Jan:139:109110. PMID: 41248718
J Cancer Res Clin Oncol

Docetaxel enhances the therapeutic efficacy of PSMA-specific CAR-T cells against prostate cancer models by suppressing MDSCs. [Abstract]

2022 Dec;148(12):3511-3520. PMID: 35962287
J Appl Polym Sci

18 February 2022.
PLoS One

RIPK2 induces docetaxel resistance in prostate cancer through the NF-κB/P-gp signaling pathway. [Abstract]

2026 Jan 21;21(1):e0341445. PMID: 41563982
Clin Transl Oncol

Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism. [Abstract]

2022 Nov;24(11):2231-2240. PMID: 35852680
Pharm Dev Technol

Dual-modified PCL-PEG nanoparticles for improved targeting and therapeutic efficacy of docetaxel against colorectal cancer. [Abstract]

2021 Oct;26(8):910-921. PMID: 34280065
Biochem Biophys Rep

Peroxiredoxin-1 as a molecular chaperone that regulates glutathione S-transferase P1 activity and drives mutidrug resistance in ovarian cancer cells. [Abstract]

2024 Jan 14:37:101639. PMID: 38288281
Anticancer Drugs

Exosomal circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) enhances the docetaxel resistance of prostate cancer via the microRNA-136-5p/tribbles homolog 1 pathway. [Abstract]

2022 Oct 1;33(9):871-882. PMID: 36136987
Oncol Lett

PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer. [Abstract]

2022 Mar;23(3):101. PMID: 35154432
Eur J Histochem

Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis. [Abstract]

2022 Oct 25;66(4). PMID: 36281649
Biomed Chromatogr

Investigation of the apoptosis-inducing effect of docetaxel by comprehensive LC-MS-based metabolomics and network pharmacology approaches. [Abstract]

2022 Sep;36(9):e5417. PMID: 35633112
Mol Biol Res Commun

Combinatorial effects of telmisartan and docetaxel on cell viability and metastatic gene expression in human prostate and breast cancer cells. [Abstract]

2022 Mar;11(1):11-20. PMID: 35463822
Int J Clin Exp Pathol

2017;10(3):3033-3042.
Preprints

2026 Mar 3.
bioRxiv

2026 Mar 27.
bioRxiv

2026 Mar 18.
bioRxiv

Loss of PIK3CA allows in vitro growth but not in vivo progression of KRAS mutant lung adenocarcinoma in a syngeneic orthotopic implantation model. [Abstract]

2026 Feb 4:2026.02.02.701385. PMID: 41676515
SSRN

2025 Dec 26.
bioRxiv

2025 Sep 21.
Res Sq

2025 Sep 7.
University of Granada

2025.
SSRN

2025 Jun 4.
bioRxiv

2025 June 01.
Res Sq

Novel mixed cancer-cell models designed to capture inter-patient tumor heterogeneity for accurate evaluation of drug combinations. [Abstract]

2025 May 16:rs.3.rs-6590535. PMID: 40470249
University of Granada

2025.
bioRxiv

Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells. [Abstract]

2025 Jan 24:2025.01.22.632572. PMID: 39896568
University of Beirut

2025.
University of Minnesota

2024.
SSRN

2024 Mar 22.
bioRxiv

Inferring therapeutic vulnerability within tumors through integration of pan-cancer cell line and single-cell transcriptomic profiles. [Abstract]

2023 Nov 1:2023.10.29.564598. PMID: 37961545
University of Adelaide

2023 Jan.
Preprints

2023 Jul 13.
Patent

US20230145200A1.
Research Square Print

November 29th, 2022.
Research Square Print

November 29th, 2022.
Oxid Med Cell Longev

Ferroptosis Induction Improves the Sensitivity of Docetaxel in Prostate Cancer. [Abstract]

2022 May 24:2022:4930643. PMID: 39282153
J Oncol

Solamargine Inhibits Prostate Cancer Cell Growth and Enhances the Therapeutic Efficacy of Docetaxel via Akt Signaling. [Abstract]

2022 Mar 10:2022:9055954. PMID: 35310915
Seoul National University

Molecular medicine and Biopharmaceutical sciences. 2021 Dec.
Nanotheranostics

Resveratrol and its Nanoparticle suppress Doxorubicin/Docetaxel-resistant anaplastic Thyroid Cancer Cells in vitro and in vivo. [Abstract]

2021 Jan 1;5(2):143-154. PMID: 33457193
Research Square Preprint

2021 Jan.
Nanotheranostics

Resveratrol and its Nanoparticle suppress Doxorubicin/Docetaxel-resistant anaplastic Thyroid Cancer Cells in vitro and in vivo. [Abstract]

2021 Jan 1;5(2):143-154. PMID: 33457193
Oncotarget

Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease. [Abstract]

2017 Dec 2;8(68):112313-112329. PMID: 29348827
Oncotarget

Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer. [Abstract]

2016 May 17;7(20):28891-902. PMID: 27049720

Docetaxel Trihydrate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 May 17;7(20):28891-902. [Abstract]

Western blot analyses for Brachyury and AR expression in prostate cell lines treated with Docetaxel (Doc) or with XRP6258 (Cab). Graphs represent the densimetric semi-quantification of western blot images.

Solvant et solubilité

In Vitro:

DMSO : 250 mg/mL (290.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (58.01 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1602 mL

5.8009 mL

11.6019 mL

5 mM

0.2320 mL

1.1602 mL

2.3204 mL

10 mM

0.1160 mL

0.5801 mL

1.1602 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (2.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 5

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (2.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 6

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (2.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocole

Cell Assay^[1]

Single-drug concentration-response curves are assessed. Seeding is done at a density of 2,000 cells/well for PC-3 and LNCaP, in 96-well plates. Cells are treated with each single drug and their combination for 72 h at different drug concentrations. Docetaxel is used at concentrations of 0.1-1,000 nM. GLU is used at concentrations of 0.1-300 µm. Cytotoxicity is assessed at the end of drug exposure using SRB assay. Following 72 h exposure the cells are fixed with 10% trichloroacetic acid (150 µL) for 1 h at 4°C. Then, cells are stained for 10 min at room temperature with 0.4% SRB dissolved in 1% acetic acid. The plates are then air dried for 24 h and the dye is made soluble with 150 µL Tris (10 mM, PH 7.4) for 5 min on a shaker at 1,600 rpm. Absorbance is then measured at 545 nM using microplate reader. Results are expressed as the relative percentage of absorbance compared to control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[3]^[4]

Mice^[3]
Five-week-old male Balb/c mice are used. Docetaxel (0, 10, 20, 30, 40, 60, and 80 mg/kg per week) is given once a week for 3 weeks for mice. Because more than 30 mg/kg per week of Docetaxel causes body weight loss in mice, 20 mg/kg per week of Docetaxel is judged to be the maximum nontoxic dose. Docetaxel (20 mg/kg per week) is given to mice once a week for 3 weeks at one of the following different points (2, 10, 14, or 22 HALO). Seventy-two hours after the final dosing of the agent, the intestinal mucosa of the small intestine (proximal 8 cm) is removed, fixed in 20 N Mildform solution (containing 8% formaldehyde in a buffered solution), and embedded in paraffin blocks, and sections of 5 μm are put on glass slides. Apoptosis is detected using the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) method, using the Apop Tag Peroxidase In Situ Apoptosis Detection Kit.
Rats^[4]
Male Sprague-Dawley rats with body weight between 230-250 g and age between 6-7 weeks are used. About 25 SD rats are divided into five groups receiving Docetaxel (7 mg/kg, i.v.), PIP (35 mg/kg, p.o.) and their combined administration (DOX+PIP) as well as PIP (3.5 mg/kg, p.o.) and PIP (3.5 mg/kg, i.v.). A day before the drug administrations, the rats are anesthetized with an intramuscular injection of a cocktail containing 60 mg/kg ketamine and 6 mg/kg xylazine (injection volume, 0.2 mL). Right jugular vein is cannulated with a polyethylene tubing (0.5 mm ID, 1 mm) for blood collection.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (292 KB)
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Portuguese - PT (557 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Attia RT, et al. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. 2016 Jun 29;4:e2168. [Content Brief]

[2]. Che CL, et al. DNA microarray reveals different pathways responding to paclitaxel and docetaxel in non-small cell lung cancer cell line. Int J Clin Exp Pathol. 2013 Jul 15;6(8):1538-48. [Content Brief]

[3]. Obi-Ioka Y, et al. Involvement of Wee1 in the circadian rhythm dependent intestinal damage induced by docetaxel. J Pharmacol Exp Ther. 2013 Oct;347(1):242-8. [Content Brief]

[4]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	1.1602 mL	5.8009 mL	11.6019 mL	29.0047 mL
	5 mM	0.2320 mL	1.1602 mL	2.3204 mL	5.8009 mL
	10 mM	0.1160 mL	0.5801 mL	1.1602 mL	2.9005 mL
	15 mM	0.0773 mL	0.3867 mL	0.7735 mL	1.9336 mL
	20 mM	0.0580 mL	0.2900 mL	0.5801 mL	1.4502 mL
	25 mM	0.0464 mL	0.2320 mL	0.4641 mL	1.1602 mL
	30 mM	0.0387 mL	0.1934 mL	0.3867 mL	0.9668 mL
	40 mM	0.0290 mL	0.1450 mL	0.2900 mL	0.7251 mL
	50 mM	0.0232 mL	0.1160 mL	0.2320 mL	0.5801 mL
DMSO	60 mM	0.0193 mL	0.0967 mL	0.1934 mL	0.4834 mL
	80 mM	0.0145 mL	0.0725 mL	0.1450 mL	0.3626 mL
	100 mM	0.0116 mL	0.0580 mL	0.1160 mL	0.2900 mL

Keywords

Docetaxel Trihydrate

165 Cited Publications

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Docetaxel Trihydrate

Apoptosis Compound Library

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Publications Citing Use of MedChemExpress (MCE) Docetaxel Trihydrate

Activité biologique

Chemical Information

Publications (165)

Solvant et solubilité

Protocole

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Docetaxel Trihydrate Related Classifications

Cat. No.: HY-B0011A