country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187660

Copy Link Print Information

rel-Avibactam

Name: rel-Avibactam
Brand: MedChemExpress
SKU: HY-187660
Availability: PreOrder

(Synonyms: rel-NXL-104 free acid; rel-AVE1330A free acid)

rel-Avibactam (rel-NXL-104 free acid) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC₅₀ of 8 nM against TEM-1 β-lactamase and an IC₅₀ of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 396731-14-9
Formule: C₇H₁₁N₃O₆S
Masse moléculaire:265.24

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

rel-Avibactam Chemical Structure

CAS No.: 396731-14-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Beta-lactamase :

Voir tous les produits spécifiques à Isoform Antibiotic :

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Avibactam potently inhibits Ambler class A, class C, and some class D β-lactamases, with a turnover number of 1. It exhibits superior potency to existing β-lactamase inhibitors, with particularly prominent inhibitory activity against the KPC enzyme^[1].
Avibactam (4 μg/mL) significantly enhances the in vitro activity of Ceftazidime (HY-B0593) against Enterobacteriaceae and Pseudomonas aeruginosa (including Ceftazidime-resistant strains), but does not potentiate the activity of Ceftazidime against Acinetobacter baumannii, Burkholderia cepacia, or Stenotrophomonas maltophilia^[1].
Avibactam (4 μg/mL) enhances the in vitro activity of Ceftazidime against Prevotella/Porphyromonas species and Fusobacterium species, but does not enhance the activity of Ceftazidime against most Bacteroides species^[1].

Others

Avibactam (5 min) potently inhibits purified TEM-1 β-lactamase from Escherichia coli (IC₅₀ = 8 nM) and purified P99 β-lactamase from Enterobacter cloacae 293HT6 (IC₅₀ = 80 nM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 396731-14-9
Masse moléculaire 265.24
Formule C₇H₁₁N₃O₆S
SMILES

NC([C@@H]1[N@]2C(N([C@](CC1)([H])C2)OS(=O)(O)=O)=O)=O
Synonyms

rel-NXL-104 free acid; rel-AVE1330A free acid
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lagacé-Wiens P, et al. Ceftazidime-avibactam: an evidence-based review of its pharmacology and potential use in the treatment of Gram-negative bacterial infections. Core evidence. 2014;9:13-25. [Content Brief]

[2]. Bonnefoy A, et al. In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor. The Journal of antimicrobial chemotherapy. 2004 Aug;54(2):410-7.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

rel-Avibactam

Voir tous les produits spécifiques à Isoform Beta-lactamase

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Description

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

rel-Avibactam

Voir tous les produits spécifiques à Isoform Beta-lactamase

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Description

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

rel-Avibactam Related Classifications

HY-187660 Related Classifications

Bioz

Keywords

Your Recently Viewed Products