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Cat. No.: HY-163741

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EZH2-IN-19

EZH2-IN-19 (conpound N40) is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) WT, with the IC₅₀ of 0.32 nM. EZH2-IN-19 plays an important role in cancer research.

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CAS No.: 3026848-13-2
Formule: C₄₀H₅₅N₇O₃
Masse moléculaire:681.91

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

EZH2-IN-19 Chemical Structure

CAS No.: 3026848-13-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

EZH2-IN-19 (conpound N40) is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) WT, with the IC₅₀ of 0.32 nM. EZH2-IN-19 plays an important role in cancer research^[1].

IC₅₀ & Target

EZH2 WT

0.32 nM (IC₅₀)

EZH2 Y641F mutant type

0.03 nM (IC₅₀)

EZH2 Y641N

0.08 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	IC₅₀	3.52 nM Compound: N40	Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 method Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 method	[PMID: 38640588]

Chemical Information

CAS No. 3026848-13-2
Masse moléculaire 681.91
Formule C₄₀H₅₅N₇O₃
SMILES

CCN(C1CCC(CC1)N(C)C)C2=CC(C3=CC=C4C(N(C(N4C5CCN(C)CC5)=O)C)=C3)=CC(C(NCC6=C(C=C(NC6=O)C)C)=O)=C2C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Di Wu, et al. Discovery of novel pyridone-benzamide derivatives possessing a 1-methyl-2-benzimidazolinone moiety as potent EZH2 inhibitors for the treatment of B-cell lymphomas. Bioorg Med Chem. 2024 May 1:105:117725. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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