γ-Elemene
γ-Elemene ((-)-γ-Elemene) is a lipid-lowering agent. γ-Elemene increases superoxide dismutase (SOD). γ-Elemene reduces the expression of adhesion molecules (VCAM-1, ICAM-1) in cells damaged by H2O2. γ-Elemene regulates lipid peroxidation. γ-Elemene protects cells from peroxidative damage induced by high fat and H2O2. γ-Elemene decreases lipid content. γ-Elemene can be used in the research of atherosclerosis.
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- CAS No.: 29873-99-2
- Formule: C15H24
- Masse moléculaire:204.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
γ-Elemene and (-)-γ-Elemene (1 μg/mL; 24 h) exert antioxidant protective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells (HUVEC). The increase rates of superoxide dismutase (SOD) induced by them are 23.75% and 22.45%, respectively, while the decrease rates of malondialdehyde (MDA) are 35.22% and 36.82%, respectively[1].
(-)-γ-Elemene (24 h) reduces the expression of adhesion factors in H2O2-injured HUVEC cells, with a reduction rate of 22.87% for VCAM-1 and 15.58% for ICAM-1[1].
(-)-γ-Elemene (24 h) reduces intracellular lipid levels in free fatty acid (FFA)-loaded HepG2 cells, with a triglyceride (TG) reduction rate of 21.39% and a non-esterified fatty acid (NEFA) reduction rate of 16.43%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human umbilical vein endothelial cells (HUVEC)
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Concentration:Not specified
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Incubation Time:24 h
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Result:Reduced ICAM-1 levels by 15.58%.
Reduced VCAM-1 levels by 22.87%.
Chemical Information
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CAS No. 29873-99-2
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Masse moléculaire 204.36
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Formule C15H24
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SMILES
C(C)(=C)[C@@H]1[C@](C=C)(C)CCC(=C(C)C)C1
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Synonyms
(-)-γ-Elemene
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
γ-Elemene Related Classifications
HY-135876 Related Classifications
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