GMC10
GMC10 is a selective MAP2K7 inhibitor with an IC50 of <1 nM for MAP2K7 and an IC50 of 340 nM for MAP2K4. GMC10 inhibits JNK pathway signaling. GMC10 enhances MRTX1133 (HY-134813)-induced Apoptosis. GMC10 can be used for research on pancreatic ductal adenocarcinoma.
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- Formule: C18H14FN3O3
- Masse moléculaire:339.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
IC50 & Target
[1]|
MAP2K7/MEK7 <1 nM (IC50) |
MAP2K4/MEK4 340 nM (IC50) |
In Vitro
GMC10 (0.1-1 μM; 24 h) inhibits Anisomycin (HY-18982)-induced JNK phosphorylation in parental KPC-2138 and CD18 PDAC cells at concentrations of 0.1 and 1 μM[1].
GMC10 inhibits pJNK[1] in parental and MRTX1133-tolerant PDAC cells during MRTX1133 exposure.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:parental mouse KPC-2138 and human CD18 PDAC cells
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Concentration:0.1 and 1 μM
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Incubation Time:24 h (figure legend); 5 h (Methods)
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Result:Effectively suppressed anisomycin-induced JNK phosphorylation at both 0.1 and 1 μM in KPC-2138 and CD18 cells.
Demonstrated slightly superior efficacy among the tested lead compounds, with a dose-dependent decrease in anisomycin-induced pJNK.
Chemical Information
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Masse moléculaire 339.32
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Formule C18H14FN3O3
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SMILES
O=C(OC)/C=C/C(NC1=CC=CC(C2=NNC3=C2C=CC(F)=C3)=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GMC10 Related Classifications
HY-189874 Related Classifications
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