GW559090
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye.
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- CAS No.: 278598-52-0
- Formule: C31H40N4O8
- Masse moléculaire:596.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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α4β1 0.19 nM (Kd) |
Chemical Information
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CAS No. 278598-52-0
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Masse moléculaire 596.67
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Formule C31H40N4O8
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SMILES
O=C(O)[C@H](CC1=CC=C(OC(N2CCC(C(N)=O)CC2)=O)C=C1)NC([C@H](CC(C)C)NC(COC3=CC=CC=C3C)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GW559090 Related Classifications
HY-171216 Related Classifications
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