Immuno modulator-1
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.
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- CAS No.: 2757469-20-6
- Formule: C32H31FN6O4
- Masse moléculaire:582.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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IL-2 |
Immuno modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cell, with an IC50 of 0.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:1 mg/kg (IV), 5 mg/kg (PO)
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Administration:IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats[1].
IV (1 mg/kg) PO (5 mg/kg) Cmax (ng/mL) 1437 AUC0-24 (ng/mL∗h) 13029 CL (mL/min/kg) 2.2 Vss (L/kg) 0.36 F (%) 30%
Chemical Information
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CAS No. 2757469-20-6
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Masse moléculaire 582.62
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Formule C32H31FN6O4
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SMILES
C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Immuno modulator-1 Related Classifications
HY-153952 Related Classifications
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