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Cat. No.: HY-148745

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JG-258

JG-258 is an inactive negative control for Hsp70 inhibitors. JG-258 is an inactive structural analog of JG-98 (HY-117282), an allosteric inhibitor of heat shock protein 70 (Hsp70) with demonstrated anticancer activity. JG-258 can be used in cancer-related research.

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CAS No.: 2241517-83-7
Formule: C₂₀H₂₂ClN₃OS₃
Masse moléculaire:452.06

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

JG-258 Chemical Structure

CAS No.: 2241517-83-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	>5 μM Compound: 32; JG-258	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 29953808]
MDA-MB-231	IC₅₀	>20 μM Compound: 32; JG-258	Antiproliferative activity against human MDA-MB-231 cells by MTT assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay	[PMID: 29953808]
MEF	IC₅₀	>20 μM Compound: 32; JG-258	Antiproliferative activity against MEF cells by MTT assay Antiproliferative activity against MEF cells by MTT assay	[PMID: 29953808]

In Vitro

JG-258 (serially increasing doses; 72 h) weakly suppresses the viability of two-dimensional cultured TT and MZ-CRC-1 human medullary thyroid carcinoma cells, with IC₅₀ values of 14.57 μM and 24.13 μM, respectively^[1].
JG-258 has no effect on Hsp70:CHIP-dependent ubiquitination of purified FLAG-tagged apo-nNOS^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2241517-83-7
Masse moléculaire 452.06
Formule C₂₀H₂₂ClN₃OS₃
SMILES

O=C1/C(S/C(N1CC)=C\C2=[N+](C=CS2)CC3=CC=CC=C3)=C4N(CCS/4)C.[Cl-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hong SK, et al. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. International journal of molecular sciences. 2022 Jan 19;23(3):1063. [Content Brief]

[2]. Davis AK, et al. Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase. Mol Pharmacol. 2020 Sep;98(3):243-249.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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JG-258

Voir tous les produits spécifiques à Isoform HSP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

JG-258 Related Classifications

HY-148745 Related Classifications