LC-PDA-01
LC-PDA-01 is a selective peroxiredoxin 1 (PRDX1) activator with an EC50 of 111.8 nM and a human KD of 123.2 nM. LC-PDA-01 inhibits the expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α. LC-PDA-01 can be used in antioxidant/anti-inflammatory research.
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- Formule: C18H15Cl2N5O4
- Masse moléculaire:436.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
LC-PDA-01 (100 μM; 3 h) significantly stabilizes endogenous PRDX1 protein in HEK-293T human embryonic kidney cells, as measured by cellular thermal shift assay[1].
LC-PDA-01 (20 μM) significantly suppresses LPS (HY-D1056)-induced expression of IL-1β, IL-6, and TNF-α mRNA in RAW 264.7 mouse macrophages[1].
LC-PDA-01 (Incubated to measure half-life of 381.6 min) shows excellent metabolic stability in mouse liver microsomes, with a half-life of 381.6 min and a hepatic extraction ratio of 13.7%[1].
LC-PDA-01 has low apparent permeability (Papp A→B = 0.06 × 10-6 cm/s) across Caco-2 monolayers, with a high efflux ratio of 5.23, suggesting potential P-gp-mediated active efflux[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 436.25
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Formule C18H15Cl2N5O4
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SMILES
NC1=CC=C(C=C1)C[C@H](C(O)=O)NC(C2=CN(N=N2)C3=CC(Cl)=CC(Cl)=C3O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LC-PDA-01 Related Classifications
HY-182308 Related Classifications
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